Liver-specific Fas silencing prevents galactosamine/lipopolysaccharide-induced liver injury

Acute liver failure (ALF) is a life threatening disease for which only few treatment options exist. The molecular pathways of disease progression are not well defined, but the death receptor Fas (CD95/Apo-1) appears to play a pivotal role in hepatocyte cell death and the development of ALF. Here, we...

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Veröffentlicht in:	Apoptosis (London) 2015-04, Vol.20 (4), p.500-511
Hauptverfasser:	Kuhla, Angela, Thrum, Michael, Schaeper, Ute, Fehring, Volker, Schulze-Topphoff, Ulf, Abshagen, Kerstin, Vollmar, Brigitte
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Biochemistry Biomedical and Life Sciences Biomedicine Cancer Research Cell Biology Fas Ligand Protein - genetics Fas Ligand Protein - metabolism fas Receptor - metabolism Galactosamine - adverse effects Gene Silencing Humans Lipopolysaccharides - adverse effects Liver Liver - cytology Liver - injuries Liver - metabolism Liver Failure, Acute - etiology Liver Failure, Acute - genetics Liver Failure, Acute - metabolism Male Mice Mice, Inbred C57BL Mortality Oncology Original Paper Survival Virology
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