A single-run liquid chromatography mass spectrometry method to quantify neuroactive kynurenine pathway metabolites in rat plasma

•A sensitive LC–MS method for quantitation of kynurenine metabolites in rat plasma.•Pool analysis of kynurenine metabolites in rat plasma.•Accurate quantification of kynurenine.•Simple and fast sample processing. Neuroactive metabolites in the kynurenine pathway of tryptophan catabolism are associat...

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Veröffentlicht in:	Journal of pharmaceutical and biomedical analysis 2015-03, Vol.107, p.426-431
Hauptverfasser:	Orsatti, Laura, Speziale, Roberto, Orsale, Maria Vittoria, Caretti, Fulvia, Veneziano, Maria, Zini, Matteo, Monteagudo, Edith, Lyons, Kathryn, Beconi, Maria, Chan, Kelvin, Herbst, Todd, Toledo-Sherman, Leticia, Munoz-Sanjuan, Ignacio, Bonelli, Fabio, Dominguez, Celia
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blood-Brain Barrier - metabolism Chromatography, High Pressure Liquid Kynurenic Acid - blood Kynurenic Acid - chemistry Kynurenine Kynurenine - blood Kynurenine - chemistry Kynurenine - metabolism Liquid chromatography Mass spectrometry ortho-Aminobenzoates - blood ortho-Aminobenzoates - chemistry Plasma Plasma - chemistry Rats Tryptophan - blood Tryptophan - chemistry Tryptophan metabolism
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