Multiplexed LC-MS/MS method for the simultaneous quantitation of three novel hepatitis C antivirals, daclatasvir, asunaprevir, and beclabuvir in human plasma

•Simultaneous quantitation of three novel HCV drugs in human plasma by LC-MS/MS.•The validation results demonstrate the method is accurate, precise, and reproducible.•Cross-validation results demonstrated method equivalency with those for single drug.•The plasma method was used for pharmacokinetic a...

Ausführliche Beschreibung