Orally administered allyl sulfides from garlic ameliorate murine colitis
SCOPE: Inflammatory bowel disease (IBD) is an incurable disease which affects millions of people. Garlic (Allium sativum) preparations have been traditionally employed for the treatment of diseases affecting the digestive tract. Here, we have investigated the effect of diallyl sulfide (DAS) and dial...
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| Veröffentlicht in: | Molecular nutrition & food research 2015-03, Vol.59 (3), p.434-442 |
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| creator | Fasolino, Ines Izzo, Angelo A Clavel, Thomas Romano, Barbara Haller, Dirk Borrelli, Francesca |
| description | SCOPE: Inflammatory bowel disease (IBD) is an incurable disease which affects millions of people. Garlic (Allium sativum) preparations have been traditionally employed for the treatment of diseases affecting the digestive tract. Here, we have investigated the effect of diallyl sulfide (DAS) and diallyl disulfide (DADS), two garlic‐derived sulfur compounds, on intestinal inflammation in vivo as well as in intestinal isolated cells. METHODS AND RESULTS: Colitis was induced in mice by intracolonic administration of dinitrobenzenesulfonic acid. Intestinal damage was assessed by evaluating colon weight/colon length ratio and by histology. Murine intestinal epithelial cells stimulated with IFN‐γ were used to evaluate the possible in vitro DAS and DADS anti‐inflammatory effects. DAS and DADS, given for two consecutive days after DNBS administration, reduced inflammation and damage. In IFN‐γ‐stimulated intestinal epithelial cells, DADS reduced IP‐10 and IL‐6 levels, while DAS inhibited nitric oxide production and STAT‐1 expression. CONCLUSION: DAS and DADS exert therapeutic effects in the DNBS model of colitis. The actions of these compounds on the production of IP‐10, IL‐6, hydrogen sulfide or nitric oxide and on the expression of STAT‐1 observed in intestinal cells stimulated with IFN‐γ, might explain the protective action of DAS and DADS in experimental IBD. |
| doi_str_mv | 10.1002/mnfr.201400347 |
| format | Article |
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Garlic (Allium sativum) preparations have been traditionally employed for the treatment of diseases affecting the digestive tract. Here, we have investigated the effect of diallyl sulfide (DAS) and diallyl disulfide (DADS), two garlic‐derived sulfur compounds, on intestinal inflammation in vivo as well as in intestinal isolated cells. METHODS AND RESULTS: Colitis was induced in mice by intracolonic administration of dinitrobenzenesulfonic acid. Intestinal damage was assessed by evaluating colon weight/colon length ratio and by histology. Murine intestinal epithelial cells stimulated with IFN‐γ were used to evaluate the possible in vitro DAS and DADS anti‐inflammatory effects. DAS and DADS, given for two consecutive days after DNBS administration, reduced inflammation and damage. In IFN‐γ‐stimulated intestinal epithelial cells, DADS reduced IP‐10 and IL‐6 levels, while DAS inhibited nitric oxide production and STAT‐1 expression. CONCLUSION: DAS and DADS exert therapeutic effects in the DNBS model of colitis. The actions of these compounds on the production of IP‐10, IL‐6, hydrogen sulfide or nitric oxide and on the expression of STAT‐1 observed in intestinal cells stimulated with IFN‐γ, might explain the protective action of DAS and DADS in experimental IBD.</description><identifier>ISSN: 1613-4125</identifier><identifier>EISSN: 1613-4133</identifier><identifier>DOI: 10.1002/mnfr.201400347</identifier><identifier>PMID: 25488545</identifier><language>eng</language><publisher>Germany: Wiley-VCH</publisher><subject>Administration, Oral ; Allium sativum ; Allyl Compounds - pharmacology ; Animals ; anti-inflammatory activity ; Anti-Inflammatory Agents, Non-Steroidal - chemistry ; Anti-Inflammatory Agents, Non-Steroidal - pharmacology ; Benzenesulfonates - toxicity ; Body Weight - drug effects ; Colitis ; Colitis - chemically induced ; Colitis - drug therapy ; Colitis - pathology ; colon ; Colon - drug effects ; Colon - pathology ; Diallyl disulfide ; Diallyl sulfide ; diallyl sulfides ; digestive tract ; Disulfides - pharmacology ; Epithelial cells ; Epithelial Cells - drug effects ; Epithelial Cells - pathology ; Food supplement ; Garlic ; Garlic - chemistry ; histology ; Hydrogen sulfide ; Hydrogen Sulfide - metabolism ; IFN-γ ; inflammation ; Inflammatory bowel disease ; Inflammatory Bowel Diseases - drug therapy ; Inflammatory Bowel Diseases - pathology ; interferon-gamma ; Interferon-gamma - pharmacology ; Interleukin-10 - genetics ; interleukin-6 ; Interleukin-6 - metabolism ; intestinal mucosa ; Male ; mice ; Mice, Inbred ICR ; Nitric oxide ; Nitrites - metabolism ; oral administration ; people ; STAT1 Transcription Factor - metabolism ; Sulfides - pharmacology ; sulfur ; therapeutics</subject><ispartof>Molecular nutrition & food research, 2015-03, Vol.59 (3), p.434-442</ispartof><rights>2014 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim</rights><rights>2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4723-db920644aaa37fea09df8e4016ef2ade83711d72decb8fa11389806e541252673</citedby><cites>FETCH-LOGICAL-c4723-db920644aaa37fea09df8e4016ef2ade83711d72decb8fa11389806e541252673</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fmnfr.201400347$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fmnfr.201400347$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25488545$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fasolino, Ines</creatorcontrib><creatorcontrib>Izzo, Angelo A</creatorcontrib><creatorcontrib>Clavel, Thomas</creatorcontrib><creatorcontrib>Romano, Barbara</creatorcontrib><creatorcontrib>Haller, Dirk</creatorcontrib><creatorcontrib>Borrelli, Francesca</creatorcontrib><title>Orally administered allyl sulfides from garlic ameliorate murine colitis</title><title>Molecular nutrition & food research</title><addtitle>Mol. Nutr. Food Res</addtitle><description>SCOPE: Inflammatory bowel disease (IBD) is an incurable disease which affects millions of people. Garlic (Allium sativum) preparations have been traditionally employed for the treatment of diseases affecting the digestive tract. Here, we have investigated the effect of diallyl sulfide (DAS) and diallyl disulfide (DADS), two garlic‐derived sulfur compounds, on intestinal inflammation in vivo as well as in intestinal isolated cells. METHODS AND RESULTS: Colitis was induced in mice by intracolonic administration of dinitrobenzenesulfonic acid. Intestinal damage was assessed by evaluating colon weight/colon length ratio and by histology. Murine intestinal epithelial cells stimulated with IFN‐γ were used to evaluate the possible in vitro DAS and DADS anti‐inflammatory effects. DAS and DADS, given for two consecutive days after DNBS administration, reduced inflammation and damage. In IFN‐γ‐stimulated intestinal epithelial cells, DADS reduced IP‐10 and IL‐6 levels, while DAS inhibited nitric oxide production and STAT‐1 expression. CONCLUSION: DAS and DADS exert therapeutic effects in the DNBS model of colitis. The actions of these compounds on the production of IP‐10, IL‐6, hydrogen sulfide or nitric oxide and on the expression of STAT‐1 observed in intestinal cells stimulated with IFN‐γ, might explain the protective action of DAS and DADS in experimental IBD.</description><subject>Administration, Oral</subject><subject>Allium sativum</subject><subject>Allyl Compounds - pharmacology</subject><subject>Animals</subject><subject>anti-inflammatory activity</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - chemistry</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - pharmacology</subject><subject>Benzenesulfonates - toxicity</subject><subject>Body Weight - drug effects</subject><subject>Colitis</subject><subject>Colitis - chemically induced</subject><subject>Colitis - drug therapy</subject><subject>Colitis - pathology</subject><subject>colon</subject><subject>Colon - drug effects</subject><subject>Colon - pathology</subject><subject>Diallyl disulfide</subject><subject>Diallyl sulfide</subject><subject>diallyl sulfides</subject><subject>digestive tract</subject><subject>Disulfides - pharmacology</subject><subject>Epithelial cells</subject><subject>Epithelial Cells - drug effects</subject><subject>Epithelial Cells - pathology</subject><subject>Food supplement</subject><subject>Garlic</subject><subject>Garlic - chemistry</subject><subject>histology</subject><subject>Hydrogen sulfide</subject><subject>Hydrogen Sulfide - metabolism</subject><subject>IFN-γ</subject><subject>inflammation</subject><subject>Inflammatory bowel disease</subject><subject>Inflammatory Bowel Diseases - drug therapy</subject><subject>Inflammatory Bowel Diseases - pathology</subject><subject>interferon-gamma</subject><subject>Interferon-gamma - pharmacology</subject><subject>Interleukin-10 - genetics</subject><subject>interleukin-6</subject><subject>Interleukin-6 - metabolism</subject><subject>intestinal mucosa</subject><subject>Male</subject><subject>mice</subject><subject>Mice, Inbred ICR</subject><subject>Nitric oxide</subject><subject>Nitrites - metabolism</subject><subject>oral administration</subject><subject>people</subject><subject>STAT1 Transcription Factor - metabolism</subject><subject>Sulfides - pharmacology</subject><subject>sulfur</subject><subject>therapeutics</subject><issn>1613-4125</issn><issn>1613-4133</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc9P2zAYhi3ERKFw3XHLcZd0_hXHPY5qtENdkWAdR-tr_BkZnKbYjbb-9yQK63UnW9bzvtb3fIR8ZHTCKOVf662LE06ZpFTI8oScM8VELpkQp8c7L0bkIqXnDmFcijMy4oXUupDFOVncRQjhkIGt_danPUa0Wf8SstQG5y2mzMWmzp4gBl9lUGPwTYQ9ZnUb_Razqgl-79Ml-eAgJLx6P8dkffP912yRL-_mP2bflnklSy5yu5lyqqQEAFE6BDq1TqOkTKHjYFGLkjFbcovVRjtgTOippgqLfgyuSjEmX4beXWxeW0x7U_tUYQiwxaZNhilFp7xQ3WdjMhnQKjYpRXRmF30N8WAYNb0909szR3td4NN7d7up0R7xf7o6QA7AHx_w8J8683N1c89Ft4oxyYdYL_jvMQbxxXQTlYV5XM2NXszvf99eM3Pb8Z8H3kFj4Cn6ZNYPXa-ilGpVaC3eAAUbk3w</recordid><startdate>201503</startdate><enddate>201503</enddate><creator>Fasolino, Ines</creator><creator>Izzo, Angelo A</creator><creator>Clavel, Thomas</creator><creator>Romano, Barbara</creator><creator>Haller, Dirk</creator><creator>Borrelli, Francesca</creator><general>Wiley-VCH</general><general>Blackwell Publishing Ltd</general><scope>FBQ</scope><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201503</creationdate><title>Orally administered allyl sulfides from garlic ameliorate murine colitis</title><author>Fasolino, Ines ; Izzo, Angelo A ; Clavel, Thomas ; Romano, Barbara ; Haller, Dirk ; Borrelli, Francesca</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4723-db920644aaa37fea09df8e4016ef2ade83711d72decb8fa11389806e541252673</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Administration, Oral</topic><topic>Allium sativum</topic><topic>Allyl Compounds - pharmacology</topic><topic>Animals</topic><topic>anti-inflammatory activity</topic><topic>Anti-Inflammatory Agents, Non-Steroidal - chemistry</topic><topic>Anti-Inflammatory Agents, Non-Steroidal - pharmacology</topic><topic>Benzenesulfonates - toxicity</topic><topic>Body Weight - drug effects</topic><topic>Colitis</topic><topic>Colitis - chemically induced</topic><topic>Colitis - drug therapy</topic><topic>Colitis - pathology</topic><topic>colon</topic><topic>Colon - drug effects</topic><topic>Colon - pathology</topic><topic>Diallyl disulfide</topic><topic>Diallyl sulfide</topic><topic>diallyl sulfides</topic><topic>digestive tract</topic><topic>Disulfides - pharmacology</topic><topic>Epithelial cells</topic><topic>Epithelial Cells - drug effects</topic><topic>Epithelial Cells - pathology</topic><topic>Food supplement</topic><topic>Garlic</topic><topic>Garlic - chemistry</topic><topic>histology</topic><topic>Hydrogen sulfide</topic><topic>Hydrogen Sulfide - metabolism</topic><topic>IFN-γ</topic><topic>inflammation</topic><topic>Inflammatory bowel disease</topic><topic>Inflammatory Bowel Diseases - drug therapy</topic><topic>Inflammatory Bowel Diseases - pathology</topic><topic>interferon-gamma</topic><topic>Interferon-gamma - pharmacology</topic><topic>Interleukin-10 - genetics</topic><topic>interleukin-6</topic><topic>Interleukin-6 - metabolism</topic><topic>intestinal mucosa</topic><topic>Male</topic><topic>mice</topic><topic>Mice, Inbred ICR</topic><topic>Nitric oxide</topic><topic>Nitrites - metabolism</topic><topic>oral administration</topic><topic>people</topic><topic>STAT1 Transcription Factor - metabolism</topic><topic>Sulfides - pharmacology</topic><topic>sulfur</topic><topic>therapeutics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fasolino, Ines</creatorcontrib><creatorcontrib>Izzo, Angelo A</creatorcontrib><creatorcontrib>Clavel, Thomas</creatorcontrib><creatorcontrib>Romano, Barbara</creatorcontrib><creatorcontrib>Haller, Dirk</creatorcontrib><creatorcontrib>Borrelli, Francesca</creatorcontrib><collection>AGRIS</collection><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Molecular nutrition & food research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fasolino, Ines</au><au>Izzo, Angelo A</au><au>Clavel, Thomas</au><au>Romano, Barbara</au><au>Haller, Dirk</au><au>Borrelli, Francesca</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Orally administered allyl sulfides from garlic ameliorate murine colitis</atitle><jtitle>Molecular nutrition & food research</jtitle><addtitle>Mol. Nutr. Food Res</addtitle><date>2015-03</date><risdate>2015</risdate><volume>59</volume><issue>3</issue><spage>434</spage><epage>442</epage><pages>434-442</pages><issn>1613-4125</issn><eissn>1613-4133</eissn><abstract>SCOPE: Inflammatory bowel disease (IBD) is an incurable disease which affects millions of people. Garlic (Allium sativum) preparations have been traditionally employed for the treatment of diseases affecting the digestive tract. Here, we have investigated the effect of diallyl sulfide (DAS) and diallyl disulfide (DADS), two garlic‐derived sulfur compounds, on intestinal inflammation in vivo as well as in intestinal isolated cells. METHODS AND RESULTS: Colitis was induced in mice by intracolonic administration of dinitrobenzenesulfonic acid. Intestinal damage was assessed by evaluating colon weight/colon length ratio and by histology. Murine intestinal epithelial cells stimulated with IFN‐γ were used to evaluate the possible in vitro DAS and DADS anti‐inflammatory effects. DAS and DADS, given for two consecutive days after DNBS administration, reduced inflammation and damage. In IFN‐γ‐stimulated intestinal epithelial cells, DADS reduced IP‐10 and IL‐6 levels, while DAS inhibited nitric oxide production and STAT‐1 expression. CONCLUSION: DAS and DADS exert therapeutic effects in the DNBS model of colitis. The actions of these compounds on the production of IP‐10, IL‐6, hydrogen sulfide or nitric oxide and on the expression of STAT‐1 observed in intestinal cells stimulated with IFN‐γ, might explain the protective action of DAS and DADS in experimental IBD.</abstract><cop>Germany</cop><pub>Wiley-VCH</pub><pmid>25488545</pmid><doi>10.1002/mnfr.201400347</doi><tpages>9</tpages></addata></record> |
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| subjects | Administration, Oral Allium sativum Allyl Compounds - pharmacology Animals anti-inflammatory activity Anti-Inflammatory Agents, Non-Steroidal - chemistry Anti-Inflammatory Agents, Non-Steroidal - pharmacology Benzenesulfonates - toxicity Body Weight - drug effects Colitis Colitis - chemically induced Colitis - drug therapy Colitis - pathology colon Colon - drug effects Colon - pathology Diallyl disulfide Diallyl sulfide diallyl sulfides digestive tract Disulfides - pharmacology Epithelial cells Epithelial Cells - drug effects Epithelial Cells - pathology Food supplement Garlic Garlic - chemistry histology Hydrogen sulfide Hydrogen Sulfide - metabolism IFN-γ inflammation Inflammatory bowel disease Inflammatory Bowel Diseases - drug therapy Inflammatory Bowel Diseases - pathology interferon-gamma Interferon-gamma - pharmacology Interleukin-10 - genetics interleukin-6 Interleukin-6 - metabolism intestinal mucosa Male mice Mice, Inbred ICR Nitric oxide Nitrites - metabolism oral administration people STAT1 Transcription Factor - metabolism Sulfides - pharmacology sulfur therapeutics |
| title | Orally administered allyl sulfides from garlic ameliorate murine colitis |
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