Broader autism phenotype in mothers predicts social responsiveness in young children with autism spectrum disorders
Aims The aim of this study was to identify phenotypes in mothers and fathers that are specifically associated with disturbances in reciprocal social interactions and communication in their young children with autism spectrum disorder (ASD) in a Japanese sample. Methods Autistic traits in parents wer...
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| Veröffentlicht in: | Psychiatry and clinical neurosciences 2015-03, Vol.69 (3), p.136-144 |
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| creator | Hasegawa, Chiaki Kikuchi, Mitsuru Yoshimura, Yuko Hiraishi, Hirotoshi Munesue, Toshio Nakatani, Hideo Higashida, Haruhiro Asada, Minoru Oi, Manabu Minabe, Yoshio |
| description | Aims
The aim of this study was to identify phenotypes in mothers and fathers that are specifically associated with disturbances in reciprocal social interactions and communication in their young children with autism spectrum disorder (ASD) in a Japanese sample.
Methods
Autistic traits in parents were evaluated using the Autism‐spectrum Quotient (AQ), the Empathy Quotient (EQ) and the Systemizing Quotient (SQ) in 88 parents (44 mothers and corresponding fathers) of children with ASD and in 60 parents (30 mothers and corresponding fathers) of typically developing (TD) children. For the measurement of autistic traits in children, we employed the Social Responsiveness Scale (SRS).
Results
In two of the five AQ subscales (social skills and communication), the parents of ASD children scored significantly higher than did the parents of TD children, regardless of whether the parent was a mother or a father. In addition, in mothers of ASD children, there were significant positive correlations between two of the five AQ subscales (attention‐switching and communication) and the SRS T‐score in their children.
Conclusions
This is the first study to demonstrate that the social skills and communication subscales in the AQ are more sensitive as autism traits in a Japanese sample and to demonstrate that some autistic traits in mothers are specifically associated with disturbances in the social ability of their young children with ASD, as measured by the SRS score. Further study is necessary to determine whether these results were caused by genetic or environmental factors. |
| doi_str_mv | 10.1111/pcn.12210 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1660925665</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3612399771</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4820-be1a3d4ac965b82dd3e96628d0cf9ed88d0f1e5c20b6b0e3a2239362aecc94663</originalsourceid><addsrcrecordid>eNp10ctKxDAUBuAgiveFLyABN7qok0sb26UO3kDUha5LmpxxIm1Sc1pl3t6Moy4Es8lZfPwJ5yfkgLNTns6kN_6UC8HZGtnmec4yXvJqPc1SyIxLrrbIDuIrY0xKxTfJlsgrJhQ_2yZ4EYO2EKkeB4cd7efgw7DogTpPuzDMISLtI1hnBqQYjNMtjYB98OjewQPiUi7C6F-ombvWRvD0ww3zn0TswQxx7Kh1GGJ6CvfIxky3CPvf9y55vrp8mt5kdw_Xt9Pzu8zkpWBZA1xLm2tTqaIphbUSKqVEaZmZVWDLNMw4FEawRjUMpBZCVlIJDcZUuVJylxyvcvsY3kbAoe4cGmhb7SGMWHOlWCUKpYpEj_7Q1zBGn373pQTjrBBJnayUiQExwqzuo-t0XNSc1csm6tRE_dVEsoffiWPTgf2VP6tPYLICH66Fxf9J9eP0fhX5Cb57lHg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1660201052</pqid></control><display><type>article</type><title>Broader autism phenotype in mothers predicts social responsiveness in young children with autism spectrum disorders</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><source>Wiley Online Library Free Content</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Freely Accessible Japanese Titles</source><source>Alma/SFX Local Collection</source><creator>Hasegawa, Chiaki ; Kikuchi, Mitsuru ; Yoshimura, Yuko ; Hiraishi, Hirotoshi ; Munesue, Toshio ; Nakatani, Hideo ; Higashida, Haruhiro ; Asada, Minoru ; Oi, Manabu ; Minabe, Yoshio</creator><creatorcontrib>Hasegawa, Chiaki ; Kikuchi, Mitsuru ; Yoshimura, Yuko ; Hiraishi, Hirotoshi ; Munesue, Toshio ; Nakatani, Hideo ; Higashida, Haruhiro ; Asada, Minoru ; Oi, Manabu ; Minabe, Yoshio</creatorcontrib><description>Aims
The aim of this study was to identify phenotypes in mothers and fathers that are specifically associated with disturbances in reciprocal social interactions and communication in their young children with autism spectrum disorder (ASD) in a Japanese sample.
Methods
Autistic traits in parents were evaluated using the Autism‐spectrum Quotient (AQ), the Empathy Quotient (EQ) and the Systemizing Quotient (SQ) in 88 parents (44 mothers and corresponding fathers) of children with ASD and in 60 parents (30 mothers and corresponding fathers) of typically developing (TD) children. For the measurement of autistic traits in children, we employed the Social Responsiveness Scale (SRS).
Results
In two of the five AQ subscales (social skills and communication), the parents of ASD children scored significantly higher than did the parents of TD children, regardless of whether the parent was a mother or a father. In addition, in mothers of ASD children, there were significant positive correlations between two of the five AQ subscales (attention‐switching and communication) and the SRS T‐score in their children.
Conclusions
This is the first study to demonstrate that the social skills and communication subscales in the AQ are more sensitive as autism traits in a Japanese sample and to demonstrate that some autistic traits in mothers are specifically associated with disturbances in the social ability of their young children with ASD, as measured by the SRS score. Further study is necessary to determine whether these results were caused by genetic or environmental factors.</description><identifier>ISSN: 1323-1316</identifier><identifier>EISSN: 1440-1819</identifier><identifier>DOI: 10.1111/pcn.12210</identifier><identifier>PMID: 24902617</identifier><language>eng</language><publisher>Australia: Wiley Subscription Services, Inc</publisher><subject>Adult ; Asian Continental Ancestry Group - psychology ; Autism ; autism spectrum disorder ; Autism Spectrum Disorder - diagnosis ; Autism Spectrum Disorder - genetics ; Autism Spectrum Disorder - psychology ; Autism‐spectrum Quotient ; Case-Control Studies ; Child ; Child, Preschool ; Empathy Quotient ; Fathers - psychology ; Female ; Genotype & phenotype ; Humans ; Interpersonal Relations ; Male ; Middle Aged ; Mothers ; Mothers - psychology ; parents ; Parents & parenting ; Phenotype ; Quantitative Trait, Heritable ; Social Behavior ; Social Responsiveness Scale ; Young Adult</subject><ispartof>Psychiatry and clinical neurosciences, 2015-03, Vol.69 (3), p.136-144</ispartof><rights>2014 The Authors. Psychiatry and Clinical Neurosciences © 2014 Japanese Society of Psychiatry and Neurology</rights><rights>2014 The Authors. Psychiatry and Clinical Neurosciences © 2014 Japanese Society of Psychiatry and Neurology.</rights><rights>Psychiatry and Clinical Neurosciences © 2015 Japanese Society of Psychiatry and Neurology</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4820-be1a3d4ac965b82dd3e96628d0cf9ed88d0f1e5c20b6b0e3a2239362aecc94663</citedby><cites>FETCH-LOGICAL-c4820-be1a3d4ac965b82dd3e96628d0cf9ed88d0f1e5c20b6b0e3a2239362aecc94663</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fpcn.12210$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fpcn.12210$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,1427,27903,27904,45553,45554,46387,46811</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24902617$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hasegawa, Chiaki</creatorcontrib><creatorcontrib>Kikuchi, Mitsuru</creatorcontrib><creatorcontrib>Yoshimura, Yuko</creatorcontrib><creatorcontrib>Hiraishi, Hirotoshi</creatorcontrib><creatorcontrib>Munesue, Toshio</creatorcontrib><creatorcontrib>Nakatani, Hideo</creatorcontrib><creatorcontrib>Higashida, Haruhiro</creatorcontrib><creatorcontrib>Asada, Minoru</creatorcontrib><creatorcontrib>Oi, Manabu</creatorcontrib><creatorcontrib>Minabe, Yoshio</creatorcontrib><title>Broader autism phenotype in mothers predicts social responsiveness in young children with autism spectrum disorders</title><title>Psychiatry and clinical neurosciences</title><addtitle>Psychiatry Clin Neurosci</addtitle><description>Aims
The aim of this study was to identify phenotypes in mothers and fathers that are specifically associated with disturbances in reciprocal social interactions and communication in their young children with autism spectrum disorder (ASD) in a Japanese sample.
Methods
Autistic traits in parents were evaluated using the Autism‐spectrum Quotient (AQ), the Empathy Quotient (EQ) and the Systemizing Quotient (SQ) in 88 parents (44 mothers and corresponding fathers) of children with ASD and in 60 parents (30 mothers and corresponding fathers) of typically developing (TD) children. For the measurement of autistic traits in children, we employed the Social Responsiveness Scale (SRS).
Results
In two of the five AQ subscales (social skills and communication), the parents of ASD children scored significantly higher than did the parents of TD children, regardless of whether the parent was a mother or a father. In addition, in mothers of ASD children, there were significant positive correlations between two of the five AQ subscales (attention‐switching and communication) and the SRS T‐score in their children.
Conclusions
This is the first study to demonstrate that the social skills and communication subscales in the AQ are more sensitive as autism traits in a Japanese sample and to demonstrate that some autistic traits in mothers are specifically associated with disturbances in the social ability of their young children with ASD, as measured by the SRS score. Further study is necessary to determine whether these results were caused by genetic or environmental factors.</description><subject>Adult</subject><subject>Asian Continental Ancestry Group - psychology</subject><subject>Autism</subject><subject>autism spectrum disorder</subject><subject>Autism Spectrum Disorder - diagnosis</subject><subject>Autism Spectrum Disorder - genetics</subject><subject>Autism Spectrum Disorder - psychology</subject><subject>Autism‐spectrum Quotient</subject><subject>Case-Control Studies</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Empathy Quotient</subject><subject>Fathers - psychology</subject><subject>Female</subject><subject>Genotype & phenotype</subject><subject>Humans</subject><subject>Interpersonal Relations</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Mothers</subject><subject>Mothers - psychology</subject><subject>parents</subject><subject>Parents & parenting</subject><subject>Phenotype</subject><subject>Quantitative Trait, Heritable</subject><subject>Social Behavior</subject><subject>Social Responsiveness Scale</subject><subject>Young Adult</subject><issn>1323-1316</issn><issn>1440-1819</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10ctKxDAUBuAgiveFLyABN7qok0sb26UO3kDUha5LmpxxIm1Sc1pl3t6Moy4Es8lZfPwJ5yfkgLNTns6kN_6UC8HZGtnmec4yXvJqPc1SyIxLrrbIDuIrY0xKxTfJlsgrJhQ_2yZ4EYO2EKkeB4cd7efgw7DogTpPuzDMISLtI1hnBqQYjNMtjYB98OjewQPiUi7C6F-ombvWRvD0ww3zn0TswQxx7Kh1GGJ6CvfIxky3CPvf9y55vrp8mt5kdw_Xt9Pzu8zkpWBZA1xLm2tTqaIphbUSKqVEaZmZVWDLNMw4FEawRjUMpBZCVlIJDcZUuVJylxyvcvsY3kbAoe4cGmhb7SGMWHOlWCUKpYpEj_7Q1zBGn373pQTjrBBJnayUiQExwqzuo-t0XNSc1csm6tRE_dVEsoffiWPTgf2VP6tPYLICH66Fxf9J9eP0fhX5Cb57lHg</recordid><startdate>201503</startdate><enddate>201503</enddate><creator>Hasegawa, Chiaki</creator><creator>Kikuchi, Mitsuru</creator><creator>Yoshimura, Yuko</creator><creator>Hiraishi, Hirotoshi</creator><creator>Munesue, Toshio</creator><creator>Nakatani, Hideo</creator><creator>Higashida, Haruhiro</creator><creator>Asada, Minoru</creator><creator>Oi, Manabu</creator><creator>Minabe, Yoshio</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>201503</creationdate><title>Broader autism phenotype in mothers predicts social responsiveness in young children with autism spectrum disorders</title><author>Hasegawa, Chiaki ; Kikuchi, Mitsuru ; Yoshimura, Yuko ; Hiraishi, Hirotoshi ; Munesue, Toshio ; Nakatani, Hideo ; Higashida, Haruhiro ; Asada, Minoru ; Oi, Manabu ; Minabe, Yoshio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4820-be1a3d4ac965b82dd3e96628d0cf9ed88d0f1e5c20b6b0e3a2239362aecc94663</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adult</topic><topic>Asian Continental Ancestry Group - psychology</topic><topic>Autism</topic><topic>autism spectrum disorder</topic><topic>Autism Spectrum Disorder - diagnosis</topic><topic>Autism Spectrum Disorder - genetics</topic><topic>Autism Spectrum Disorder - psychology</topic><topic>Autism‐spectrum Quotient</topic><topic>Case-Control Studies</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Empathy Quotient</topic><topic>Fathers - psychology</topic><topic>Female</topic><topic>Genotype & phenotype</topic><topic>Humans</topic><topic>Interpersonal Relations</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Mothers</topic><topic>Mothers - psychology</topic><topic>parents</topic><topic>Parents & parenting</topic><topic>Phenotype</topic><topic>Quantitative Trait, Heritable</topic><topic>Social Behavior</topic><topic>Social Responsiveness Scale</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hasegawa, Chiaki</creatorcontrib><creatorcontrib>Kikuchi, Mitsuru</creatorcontrib><creatorcontrib>Yoshimura, Yuko</creatorcontrib><creatorcontrib>Hiraishi, Hirotoshi</creatorcontrib><creatorcontrib>Munesue, Toshio</creatorcontrib><creatorcontrib>Nakatani, Hideo</creatorcontrib><creatorcontrib>Higashida, Haruhiro</creatorcontrib><creatorcontrib>Asada, Minoru</creatorcontrib><creatorcontrib>Oi, Manabu</creatorcontrib><creatorcontrib>Minabe, Yoshio</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Psychiatry and clinical neurosciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hasegawa, Chiaki</au><au>Kikuchi, Mitsuru</au><au>Yoshimura, Yuko</au><au>Hiraishi, Hirotoshi</au><au>Munesue, Toshio</au><au>Nakatani, Hideo</au><au>Higashida, Haruhiro</au><au>Asada, Minoru</au><au>Oi, Manabu</au><au>Minabe, Yoshio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Broader autism phenotype in mothers predicts social responsiveness in young children with autism spectrum disorders</atitle><jtitle>Psychiatry and clinical neurosciences</jtitle><addtitle>Psychiatry Clin Neurosci</addtitle><date>2015-03</date><risdate>2015</risdate><volume>69</volume><issue>3</issue><spage>136</spage><epage>144</epage><pages>136-144</pages><issn>1323-1316</issn><eissn>1440-1819</eissn><abstract>Aims
The aim of this study was to identify phenotypes in mothers and fathers that are specifically associated with disturbances in reciprocal social interactions and communication in their young children with autism spectrum disorder (ASD) in a Japanese sample.
Methods
Autistic traits in parents were evaluated using the Autism‐spectrum Quotient (AQ), the Empathy Quotient (EQ) and the Systemizing Quotient (SQ) in 88 parents (44 mothers and corresponding fathers) of children with ASD and in 60 parents (30 mothers and corresponding fathers) of typically developing (TD) children. For the measurement of autistic traits in children, we employed the Social Responsiveness Scale (SRS).
Results
In two of the five AQ subscales (social skills and communication), the parents of ASD children scored significantly higher than did the parents of TD children, regardless of whether the parent was a mother or a father. In addition, in mothers of ASD children, there were significant positive correlations between two of the five AQ subscales (attention‐switching and communication) and the SRS T‐score in their children.
Conclusions
This is the first study to demonstrate that the social skills and communication subscales in the AQ are more sensitive as autism traits in a Japanese sample and to demonstrate that some autistic traits in mothers are specifically associated with disturbances in the social ability of their young children with ASD, as measured by the SRS score. Further study is necessary to determine whether these results were caused by genetic or environmental factors.</abstract><cop>Australia</cop><pub>Wiley Subscription Services, Inc</pub><pmid>24902617</pmid><doi>10.1111/pcn.12210</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Asian Continental Ancestry Group - psychology Autism autism spectrum disorder Autism Spectrum Disorder - diagnosis Autism Spectrum Disorder - genetics Autism Spectrum Disorder - psychology Autism‐spectrum Quotient Case-Control Studies Child Child, Preschool Empathy Quotient Fathers - psychology Female Genotype & phenotype Humans Interpersonal Relations Male Middle Aged Mothers Mothers - psychology parents Parents & parenting Phenotype Quantitative Trait, Heritable Social Behavior Social Responsiveness Scale Young Adult |
| title | Broader autism phenotype in mothers predicts social responsiveness in young children with autism spectrum disorders |
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