Blockade by fenspiride of endotoxin-induced neutrophil migration in the rat

Fenspiride, an antiinflammatory drug with low anti-cyclooxygenase activity, administered orally at 60–200 mg/kg inhibited neutrophil migration into peritoneal and air pouches cavities as well as exudation into peritoneal cavities induced by endotoxin but not induced by carrageenin. Up to 100 μM, fen...

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Veröffentlicht in:	European journal of pharmacology 1993-07, Vol.238 (1), p.47-52
Hauptverfasser:	Cunha, Fernando Q., Boukili, Mohamed A., Braga da Motta, Joelson I., Vargaftig, Bernardo B., Ferreira, Sérgio H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Animals Biological and medical sciences Bones, joints and connective tissue. Antiinflammatory agents Capillary Permeability - drug effects Carrageenan - toxicity Carrageenin Cell Movement - drug effects Endotoxin Endotoxins - toxicity Fenspiride Interleukin-8 - metabolism Interleukin-8 - pharmacology Macrophages - drug effects Macrophages - metabolism Male Medical sciences Neutrophil migration Neutrophils - drug effects Neutrophils - physiology Peritoneal Cavity - cytology Pharmacology. Drug treatments Rats Rats, Wistar Spiro Compounds - administration & dosage Spiro Compounds - pharmacology Tumor Necrosis Factor-alpha - metabolism Tumour necrosis factor
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