Axis specification in the developing Drosophila appendage: The role of wingless, decapentaplegic, and the homeobox gene aristaless
The wingless (wg) and decapentaplegic (dpp) genes of Drosophila encode homologs of secreted growth factors and are required for the correct patterning of the appendages. We show that the presumptive tips of both the leg and wing, the distal extreme of the proximodistal axis, are characterized by the...
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| Veröffentlicht in: | Cell 1993-09, Vol.74 (6), p.1113-1123 |
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| creator | Campbell, Gerard Weaver, Thomas Tomlinson, Andrew |
| description | The
wingless (wg) and
decapentaplegic (dpp) genes of Drosophila encode homologs of secreted growth factors and are required for the correct patterning of the appendages. We show that the presumptive tips of both the leg and wing, the distal extreme of the proximodistal axis, are characterized by the close association of cells expressing
wg, dpp, and the homeobox gene
aristaless (al). Ectopic expression of
wg can induce both ectopic
al expression and a duplication of the proximodistal axis (the development of supernumerary legs), but only in regions expressing high levels of
dpp. Ectopic
al expression can induce a duplication of the proximodistal axis in the wing, suggesting that it may also be directly involved in axis specification. The proximodistal axis may be specified via a mechanism involving a direct interaction between cells expressing
wg, dpp, and possibly
al. |
| doi_str_mv | 10.1016/0092-8674(93)90732-6 |
| format | Article |
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wingless (wg) and
decapentaplegic (dpp) genes of Drosophila encode homologs of secreted growth factors and are required for the correct patterning of the appendages. We show that the presumptive tips of both the leg and wing, the distal extreme of the proximodistal axis, are characterized by the close association of cells expressing
wg, dpp, and the homeobox gene
aristaless (al). Ectopic expression of
wg can induce both ectopic
al expression and a duplication of the proximodistal axis (the development of supernumerary legs), but only in regions expressing high levels of
dpp. Ectopic
al expression can induce a duplication of the proximodistal axis in the wing, suggesting that it may also be directly involved in axis specification. The proximodistal axis may be specified via a mechanism involving a direct interaction between cells expressing
wg, dpp, and possibly
al.</description><identifier>ISSN: 0092-8674</identifier><identifier>EISSN: 1097-4172</identifier><identifier>DOI: 10.1016/0092-8674(93)90732-6</identifier><identifier>PMID: 8104704</identifier><identifier>CODEN: CELLB5</identifier><language>eng</language><publisher>Cambridge, MA: Elsevier Inc</publisher><subject>Animals ; Base Sequence ; Biological and medical sciences ; Cell differentiation, maturation, development, hematopoiesis ; Cell physiology ; Conserved Sequence ; DNA - genetics ; Drosophila ; Drosophila - genetics ; Drosophila - growth & development ; Fundamental and applied biological sciences. Psychology ; Gene Expression ; Gene Library ; Genes, Homeobox ; Heat-Shock Proteins - biosynthesis ; In Situ Hybridization ; Insecta ; Invertebrates ; Life cycle. Embryology. Development ; Molecular and cellular biology ; Molecular Sequence Data ; Multigene Family ; Mutagenesis ; Oligodeoxyribonucleotides ; Physiology. Development ; Promoter Regions, Genetic ; Transcription, Genetic ; Tubulin - genetics ; Wings, Animal - anatomy & histology</subject><ispartof>Cell, 1993-09, Vol.74 (6), p.1113-1123</ispartof><rights>1993</rights><rights>1993 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c483t-683a94cc62be9382c6eb12e2424987782d83e5147808b4a0f21818b19fd94d573</citedby><cites>FETCH-LOGICAL-c483t-683a94cc62be9382c6eb12e2424987782d83e5147808b4a0f21818b19fd94d573</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0092-8674(93)90732-6$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27923,27924,45994</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4916449$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8104704$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Campbell, Gerard</creatorcontrib><creatorcontrib>Weaver, Thomas</creatorcontrib><creatorcontrib>Tomlinson, Andrew</creatorcontrib><title>Axis specification in the developing Drosophila appendage: The role of wingless, decapentaplegic, and the homeobox gene aristaless</title><title>Cell</title><addtitle>Cell</addtitle><description>The
wingless (wg) and
decapentaplegic (dpp) genes of Drosophila encode homologs of secreted growth factors and are required for the correct patterning of the appendages. We show that the presumptive tips of both the leg and wing, the distal extreme of the proximodistal axis, are characterized by the close association of cells expressing
wg, dpp, and the homeobox gene
aristaless (al). Ectopic expression of
wg can induce both ectopic
al expression and a duplication of the proximodistal axis (the development of supernumerary legs), but only in regions expressing high levels of
dpp. Ectopic
al expression can induce a duplication of the proximodistal axis in the wing, suggesting that it may also be directly involved in axis specification. The proximodistal axis may be specified via a mechanism involving a direct interaction between cells expressing
wg, dpp, and possibly
al.</description><subject>Animals</subject><subject>Base Sequence</subject><subject>Biological and medical sciences</subject><subject>Cell differentiation, maturation, development, hematopoiesis</subject><subject>Cell physiology</subject><subject>Conserved Sequence</subject><subject>DNA - genetics</subject><subject>Drosophila</subject><subject>Drosophila - genetics</subject><subject>Drosophila - growth & development</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene Expression</subject><subject>Gene Library</subject><subject>Genes, Homeobox</subject><subject>Heat-Shock Proteins - biosynthesis</subject><subject>In Situ Hybridization</subject><subject>Insecta</subject><subject>Invertebrates</subject><subject>Life cycle. Embryology. Development</subject><subject>Molecular and cellular biology</subject><subject>Molecular Sequence Data</subject><subject>Multigene Family</subject><subject>Mutagenesis</subject><subject>Oligodeoxyribonucleotides</subject><subject>Physiology. Development</subject><subject>Promoter Regions, Genetic</subject><subject>Transcription, Genetic</subject><subject>Tubulin - genetics</subject><subject>Wings, Animal - anatomy & histology</subject><issn>0092-8674</issn><issn>1097-4172</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE2LFDEQhoMo67j6DxRyEFHY1iSdzocHYVk_YcHLeg7ppHomkknapGddr_5yMzvDHD3VoZ73pepB6Dklbymh4h0hmnVKSP5a9280kT3rxAO0okTLjlPJHqLVCXmMntT6kxCihmE4Q2eKEi4JX6G_l3eh4jqDC1Nwdgk54ZDwsgHs4RZinkNa448l1zxvQrTYzjMkb9fwHt80qOQIOE_4d8Mi1HrRYs42ZLFzhHVwF9gmf9-3yVvIY77Da0iAbQl1sfvIU_RosrHCs-M8Rz8-f7q5-tpdf__y7eryunNc9UsnVG81d06wEXSvmBMwUgaMM66VlIp51cNAuVREjdySiVFF1Uj15DX3g-zP0atD71zyrx3UxWxDdRCjTZB31VAhiGh-GsgPoGtv1wKTmUvY2vLHUGL26s3eq9l7Nbo39-qNaLEXx_7duAV_Ch1dt_3L495WZ-NUbHKhnjCuqeBcN-zDAYPm4jZAMdUFSA58KOAW43P4_x3_AAv7oE8</recordid><startdate>19930924</startdate><enddate>19930924</enddate><creator>Campbell, Gerard</creator><creator>Weaver, Thomas</creator><creator>Tomlinson, Andrew</creator><general>Elsevier Inc</general><general>Cell Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SS</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope></search><sort><creationdate>19930924</creationdate><title>Axis specification in the developing Drosophila appendage: The role of wingless, decapentaplegic, and the homeobox gene aristaless</title><author>Campbell, Gerard ; Weaver, Thomas ; Tomlinson, Andrew</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c483t-683a94cc62be9382c6eb12e2424987782d83e5147808b4a0f21818b19fd94d573</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Animals</topic><topic>Base Sequence</topic><topic>Biological and medical sciences</topic><topic>Cell differentiation, maturation, development, hematopoiesis</topic><topic>Cell physiology</topic><topic>Conserved Sequence</topic><topic>DNA - genetics</topic><topic>Drosophila</topic><topic>Drosophila - genetics</topic><topic>Drosophila - growth & development</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene Expression</topic><topic>Gene Library</topic><topic>Genes, Homeobox</topic><topic>Heat-Shock Proteins - biosynthesis</topic><topic>In Situ Hybridization</topic><topic>Insecta</topic><topic>Invertebrates</topic><topic>Life cycle. Embryology. Development</topic><topic>Molecular and cellular biology</topic><topic>Molecular Sequence Data</topic><topic>Multigene Family</topic><topic>Mutagenesis</topic><topic>Oligodeoxyribonucleotides</topic><topic>Physiology. Development</topic><topic>Promoter Regions, Genetic</topic><topic>Transcription, Genetic</topic><topic>Tubulin - genetics</topic><topic>Wings, Animal - anatomy & histology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Campbell, Gerard</creatorcontrib><creatorcontrib>Weaver, Thomas</creatorcontrib><creatorcontrib>Tomlinson, Andrew</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><jtitle>Cell</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Campbell, Gerard</au><au>Weaver, Thomas</au><au>Tomlinson, Andrew</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Axis specification in the developing Drosophila appendage: The role of wingless, decapentaplegic, and the homeobox gene aristaless</atitle><jtitle>Cell</jtitle><addtitle>Cell</addtitle><date>1993-09-24</date><risdate>1993</risdate><volume>74</volume><issue>6</issue><spage>1113</spage><epage>1123</epage><pages>1113-1123</pages><issn>0092-8674</issn><eissn>1097-4172</eissn><coden>CELLB5</coden><abstract>The
wingless (wg) and
decapentaplegic (dpp) genes of Drosophila encode homologs of secreted growth factors and are required for the correct patterning of the appendages. We show that the presumptive tips of both the leg and wing, the distal extreme of the proximodistal axis, are characterized by the close association of cells expressing
wg, dpp, and the homeobox gene
aristaless (al). Ectopic expression of
wg can induce both ectopic
al expression and a duplication of the proximodistal axis (the development of supernumerary legs), but only in regions expressing high levels of
dpp. Ectopic
al expression can induce a duplication of the proximodistal axis in the wing, suggesting that it may also be directly involved in axis specification. The proximodistal axis may be specified via a mechanism involving a direct interaction between cells expressing
wg, dpp, and possibly
al.</abstract><cop>Cambridge, MA</cop><pub>Elsevier Inc</pub><pmid>8104704</pmid><doi>10.1016/0092-8674(93)90732-6</doi><tpages>11</tpages></addata></record> |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Animals Base Sequence Biological and medical sciences Cell differentiation, maturation, development, hematopoiesis Cell physiology Conserved Sequence DNA - genetics Drosophila Drosophila - genetics Drosophila - growth & development Fundamental and applied biological sciences. Psychology Gene Expression Gene Library Genes, Homeobox Heat-Shock Proteins - biosynthesis In Situ Hybridization Insecta Invertebrates Life cycle. Embryology. Development Molecular and cellular biology Molecular Sequence Data Multigene Family Mutagenesis Oligodeoxyribonucleotides Physiology. Development Promoter Regions, Genetic Transcription, Genetic Tubulin - genetics Wings, Animal - anatomy & histology |
| title | Axis specification in the developing Drosophila appendage: The role of wingless, decapentaplegic, and the homeobox gene aristaless |
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