The proteomic 2D-DIGE approach reveals the protein voltage-dependent anion channel 2 as a potential therapeutic target in epithelial thyroid tumours

•We propose the mitochondrial VACD2 protein as a novel gene for developing therapeutic strategies.•The proteomic 2D-DIGE system is a useful tool to identify new candidate genes.•The 2D-DIGE analysis is a useful tool to compare differentially expressed proteins in epithelial thyroid carcinoma. We inv...

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Veröffentlicht in:	Molecular and cellular endocrinology 2015-03, Vol.404, p.37-45
Hauptverfasser:	Mato, Eugenia, Barceló-Batllori, Sílvia, Orera, Irene, Selva, Laia, Corra, Martina, González, Cintia, Bell, Olga, Lerma, Enrique, Moral, Antonio, Pérez, José Ignacio, de Leiva, Alberto
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Aged, 80 and over bcl-2 Homologous Antagonist-Killer Protein - genetics bcl-2 Homologous Antagonist-Killer Protein - metabolism bcl-2-Associated X Protein - metabolism Cell Line, Tumor Epithelial thyroid tumours Female Humans Male Middle Aged Neoplasms, Glandular and Epithelial - drug therapy Neoplasms, Glandular and Epithelial - metabolism Neoplasms, Glandular and Epithelial - pathology Niacinamide - analogs & derivatives Niacinamide - pharmacology Phenylurea Compounds - pharmacology Proteomics - methods Therapeutic target Thyroid Neoplasms - drug therapy Thyroid Neoplasms - metabolism Thyroid Neoplasms - pathology Two-Dimensional Difference Gel Electrophoresis - methods Up-Regulation Voltage-dependent anion channel 2 Voltage-Dependent Anion Channel 2 - genetics Voltage-Dependent Anion Channel 2 - metabolism Young Adult
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