Operationalizing protocol differences for EADC-ADNI manual hippocampal segmentation

Abstract Background Hippocampal volumetry on magnetic resonance imaging is recognized as an Alzheimer's disease (AD) biomarker, and manual segmentation is the gold standard for measurement. However, a standard procedure is lacking. We operationalize and quantitate landmark differences to help a...

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Veröffentlicht in:	Alzheimer's & dementia 2015-02, Vol.11 (2), p.184-194
Hauptverfasser:	Boccardi, Marina, Bocchetta, Martina, Ganzola, Rossana, Robitaille, Nicolas, Redolfi, Alberto, Duchesne, Simon, Jack, Clifford R, Frisoni, Giovanni B
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Alzheimer Disease - pathology Alzheimer's disease Alzheimer's Disease Neuroimaging Initiative Anatomic landmark Atrophy Cognitive Dysfunction - pathology Degeneration Delphi Technique Female Harmonization Hippocampal atrophy Hippocampal volumetry Hippocampus Hippocampus - anatomy & histology Hippocampus - pathology Humans Image Processing, Computer-Assisted - methods Imaging, Three-Dimensional - methods Magnetic resonance Magnetic Resonance Imaging - instrumentation Magnetic Resonance Imaging - methods Male Manual segmentation protocol Manual tracing Medial temporal lobes Neuroimaging Neuroimaging - methods Neurology Organ Size Reproducibility of Results Standard operating procedures
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