Operationalizing protocol differences for EADC-ADNI manual hippocampal segmentation
Abstract Background Hippocampal volumetry on magnetic resonance imaging is recognized as an Alzheimer's disease (AD) biomarker, and manual segmentation is the gold standard for measurement. However, a standard procedure is lacking. We operationalize and quantitate landmark differences to help a...
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| Veröffentlicht in: | Alzheimer's & dementia 2015-02, Vol.11 (2), p.184-194 |
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| creator | Boccardi, Marina Bocchetta, Martina Ganzola, Rossana Robitaille, Nicolas Redolfi, Alberto Duchesne, Simon Jack, Clifford R Frisoni, Giovanni B |
| description | Abstract Background Hippocampal volumetry on magnetic resonance imaging is recognized as an Alzheimer's disease (AD) biomarker, and manual segmentation is the gold standard for measurement. However, a standard procedure is lacking. We operationalize and quantitate landmark differences to help a Delphi panel converge on a set of landmarks. Methods One hundred percent of anatomic landmark variability across 12 different protocols for manual segmentation was reduced into four segmentation units (the minimum hippocampus, the alveus/fimbria, the tail, and the subiculum), which were segmented on magnetic resonance images by expert raters to estimate reliability and AD-related atrophy. Results Intra- and interrater reliability were more than 0.96 and 0.92, respectively, except for the alveus/fimbria, which were 0.86 and 0.77, respectively. Of all AD-related atrophy, the minimum hippocampus contributed to 67%; tail, 24%; alveus/fimbria, 4%; and the subiculum, 5%. Conclusions Anatomic landmark variability in available protocols can be reduced to four discrete and measurable segmentation units. Their quantitative assessment will help a Delphi panel to define a set of landmarks for a harmonized protocol. |
| doi_str_mv | 10.1016/j.jalz.2013.03.001 |
| format | Article |
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However, a standard procedure is lacking. We operationalize and quantitate landmark differences to help a Delphi panel converge on a set of landmarks. Methods One hundred percent of anatomic landmark variability across 12 different protocols for manual segmentation was reduced into four segmentation units (the minimum hippocampus, the alveus/fimbria, the tail, and the subiculum), which were segmented on magnetic resonance images by expert raters to estimate reliability and AD-related atrophy. Results Intra- and interrater reliability were more than 0.96 and 0.92, respectively, except for the alveus/fimbria, which were 0.86 and 0.77, respectively. Of all AD-related atrophy, the minimum hippocampus contributed to 67%; tail, 24%; alveus/fimbria, 4%; and the subiculum, 5%. Conclusions Anatomic landmark variability in available protocols can be reduced to four discrete and measurable segmentation units. Their quantitative assessment will help a Delphi panel to define a set of landmarks for a harmonized protocol.</description><identifier>ISSN: 1552-5260</identifier><identifier>EISSN: 1552-5279</identifier><identifier>DOI: 10.1016/j.jalz.2013.03.001</identifier><identifier>PMID: 23706515</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Aged ; Alzheimer Disease - pathology ; Alzheimer's disease ; Alzheimer's Disease Neuroimaging Initiative ; Anatomic landmark ; Atrophy ; Cognitive Dysfunction - pathology ; Degeneration ; Delphi Technique ; Female ; Harmonization ; Hippocampal atrophy ; Hippocampal volumetry ; Hippocampus ; Hippocampus - anatomy & histology ; Hippocampus - pathology ; Humans ; Image Processing, Computer-Assisted - methods ; Imaging, Three-Dimensional - methods ; Magnetic resonance ; Magnetic Resonance Imaging - instrumentation ; Magnetic Resonance Imaging - methods ; Male ; Manual segmentation protocol ; Manual tracing ; Medial temporal lobes ; Neuroimaging ; Neuroimaging - methods ; Neurology ; Organ Size ; Reproducibility of Results ; Standard operating procedures</subject><ispartof>Alzheimer's & dementia, 2015-02, Vol.11 (2), p.184-194</ispartof><rights>The Alzheimer's Association</rights><rights>2015 The Alzheimer's Association</rights><rights>Copyright © 2015 The Alzheimer's Association. Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c6491-ca3d9d1fd04e639bc577c5b6bc7a9d0874ca05fa6197cba5670a6ec8ce459fe63</citedby><cites>FETCH-LOGICAL-c6491-ca3d9d1fd04e639bc577c5b6bc7a9d0874ca05fa6197cba5670a6ec8ce459fe63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1016%2Fj.jalz.2013.03.001$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1016%2Fj.jalz.2013.03.001$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23706515$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Boccardi, Marina</creatorcontrib><creatorcontrib>Bocchetta, Martina</creatorcontrib><creatorcontrib>Ganzola, Rossana</creatorcontrib><creatorcontrib>Robitaille, Nicolas</creatorcontrib><creatorcontrib>Redolfi, Alberto</creatorcontrib><creatorcontrib>Duchesne, Simon</creatorcontrib><creatorcontrib>Jack, Clifford R</creatorcontrib><creatorcontrib>Frisoni, Giovanni B</creatorcontrib><creatorcontrib>EADC-ADNI Working Group on The Harmonized Protocol for Manual Hippocampal Segmentation and for the Alzheimer's Disease Neuroimaging Initiative</creatorcontrib><creatorcontrib>EADC‐ADNI Working Group on The Harmonized Protocol for Manual Hippocampal Segmentation and for the Alzheimer's Disease Neuroimaging Initiative</creatorcontrib><title>Operationalizing protocol differences for EADC-ADNI manual hippocampal segmentation</title><title>Alzheimer's & dementia</title><addtitle>Alzheimers Dement</addtitle><description>Abstract Background Hippocampal volumetry on magnetic resonance imaging is recognized as an Alzheimer's disease (AD) biomarker, and manual segmentation is the gold standard for measurement. However, a standard procedure is lacking. We operationalize and quantitate landmark differences to help a Delphi panel converge on a set of landmarks. Methods One hundred percent of anatomic landmark variability across 12 different protocols for manual segmentation was reduced into four segmentation units (the minimum hippocampus, the alveus/fimbria, the tail, and the subiculum), which were segmented on magnetic resonance images by expert raters to estimate reliability and AD-related atrophy. Results Intra- and interrater reliability were more than 0.96 and 0.92, respectively, except for the alveus/fimbria, which were 0.86 and 0.77, respectively. Of all AD-related atrophy, the minimum hippocampus contributed to 67%; tail, 24%; alveus/fimbria, 4%; and the subiculum, 5%. Conclusions Anatomic landmark variability in available protocols can be reduced to four discrete and measurable segmentation units. Their quantitative assessment will help a Delphi panel to define a set of landmarks for a harmonized protocol.</description><subject>Aged</subject><subject>Alzheimer Disease - pathology</subject><subject>Alzheimer's disease</subject><subject>Alzheimer's Disease Neuroimaging Initiative</subject><subject>Anatomic landmark</subject><subject>Atrophy</subject><subject>Cognitive Dysfunction - pathology</subject><subject>Degeneration</subject><subject>Delphi Technique</subject><subject>Female</subject><subject>Harmonization</subject><subject>Hippocampal atrophy</subject><subject>Hippocampal volumetry</subject><subject>Hippocampus</subject><subject>Hippocampus - anatomy & histology</subject><subject>Hippocampus - pathology</subject><subject>Humans</subject><subject>Image Processing, Computer-Assisted - methods</subject><subject>Imaging, Three-Dimensional - methods</subject><subject>Magnetic resonance</subject><subject>Magnetic Resonance Imaging - instrumentation</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Male</subject><subject>Manual segmentation protocol</subject><subject>Manual tracing</subject><subject>Medial temporal lobes</subject><subject>Neuroimaging</subject><subject>Neuroimaging - methods</subject><subject>Neurology</subject><subject>Organ Size</subject><subject>Reproducibility of Results</subject><subject>Standard operating procedures</subject><issn>1552-5260</issn><issn>1552-5279</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNksFu1DAQhi0EomXhBTigHLlkGSexvZEQUrQt0GpFD4ULF8txJsXBiVM7AW2fHoeUHjggJMszsv75Z_R5CHlJYUuB8jfdtlP2bpsBzbcQD9BH5JQylqUsE-Xjh5zDCXkWQgdQwI6yp-QkywVwRtkpub4a0avJuEFZc2eGm2T0bnLa2aQxbYseB40haZ1PzquzfVqdfbpIejXMyibfzDg6rfox5gFvehym307PyZNW2YAv7uOGfHl__nn_MT1cfbjYV4dU86KkqVZ5Uza0baBAnpe1ZkJoVvNaC1U2sBOFVsBaxWkpdK0YF6A46p3GgpVtLNmQ16tvHPl2xjDJ3gSN1qoB3Rwk5Rw4jxCKKM1WqfYuBI-tHL3plT9KCnKBKTu5wJQLTAnxxLghr-7957rH5qHkD70oqFbBT2Px-B-Wsjp8vbyM1_IG-drk7eqBkdQPg14GbRbojfGoJ9k48-8Z3_1Vrq0ZjFb2Ox4xdG728WcjCxkyCfJ6WYllI2J7ALHL8l8Rzq7i</recordid><startdate>201502</startdate><enddate>201502</enddate><creator>Boccardi, Marina</creator><creator>Bocchetta, Martina</creator><creator>Ganzola, Rossana</creator><creator>Robitaille, Nicolas</creator><creator>Redolfi, Alberto</creator><creator>Duchesne, Simon</creator><creator>Jack, Clifford R</creator><creator>Frisoni, Giovanni B</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201502</creationdate><title>Operationalizing protocol differences for EADC-ADNI manual hippocampal segmentation</title><author>Boccardi, Marina ; Bocchetta, Martina ; Ganzola, Rossana ; Robitaille, Nicolas ; Redolfi, Alberto ; Duchesne, Simon ; Jack, Clifford R ; Frisoni, Giovanni B</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c6491-ca3d9d1fd04e639bc577c5b6bc7a9d0874ca05fa6197cba5670a6ec8ce459fe63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Aged</topic><topic>Alzheimer Disease - pathology</topic><topic>Alzheimer's disease</topic><topic>Alzheimer's Disease Neuroimaging Initiative</topic><topic>Anatomic landmark</topic><topic>Atrophy</topic><topic>Cognitive Dysfunction - pathology</topic><topic>Degeneration</topic><topic>Delphi Technique</topic><topic>Female</topic><topic>Harmonization</topic><topic>Hippocampal atrophy</topic><topic>Hippocampal volumetry</topic><topic>Hippocampus</topic><topic>Hippocampus - anatomy & histology</topic><topic>Hippocampus - pathology</topic><topic>Humans</topic><topic>Image Processing, Computer-Assisted - methods</topic><topic>Imaging, Three-Dimensional - methods</topic><topic>Magnetic resonance</topic><topic>Magnetic Resonance Imaging - instrumentation</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Male</topic><topic>Manual segmentation protocol</topic><topic>Manual tracing</topic><topic>Medial temporal lobes</topic><topic>Neuroimaging</topic><topic>Neuroimaging - methods</topic><topic>Neurology</topic><topic>Organ Size</topic><topic>Reproducibility of Results</topic><topic>Standard operating procedures</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Boccardi, Marina</creatorcontrib><creatorcontrib>Bocchetta, Martina</creatorcontrib><creatorcontrib>Ganzola, Rossana</creatorcontrib><creatorcontrib>Robitaille, Nicolas</creatorcontrib><creatorcontrib>Redolfi, Alberto</creatorcontrib><creatorcontrib>Duchesne, Simon</creatorcontrib><creatorcontrib>Jack, Clifford R</creatorcontrib><creatorcontrib>Frisoni, Giovanni B</creatorcontrib><creatorcontrib>EADC-ADNI Working Group on The Harmonized Protocol for Manual Hippocampal Segmentation and for the Alzheimer's Disease Neuroimaging Initiative</creatorcontrib><creatorcontrib>EADC‐ADNI Working Group on The Harmonized Protocol for Manual Hippocampal Segmentation and for the Alzheimer's Disease Neuroimaging Initiative</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Alzheimer's & dementia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Boccardi, Marina</au><au>Bocchetta, Martina</au><au>Ganzola, Rossana</au><au>Robitaille, Nicolas</au><au>Redolfi, Alberto</au><au>Duchesne, Simon</au><au>Jack, Clifford R</au><au>Frisoni, Giovanni B</au><aucorp>EADC-ADNI Working Group on The Harmonized Protocol for Manual Hippocampal Segmentation and for the Alzheimer's Disease Neuroimaging Initiative</aucorp><aucorp>EADC‐ADNI Working Group on The Harmonized Protocol for Manual Hippocampal Segmentation and for the Alzheimer's Disease Neuroimaging Initiative</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Operationalizing protocol differences for EADC-ADNI manual hippocampal segmentation</atitle><jtitle>Alzheimer's & dementia</jtitle><addtitle>Alzheimers Dement</addtitle><date>2015-02</date><risdate>2015</risdate><volume>11</volume><issue>2</issue><spage>184</spage><epage>194</epage><pages>184-194</pages><issn>1552-5260</issn><eissn>1552-5279</eissn><abstract>Abstract Background Hippocampal volumetry on magnetic resonance imaging is recognized as an Alzheimer's disease (AD) biomarker, and manual segmentation is the gold standard for measurement. However, a standard procedure is lacking. We operationalize and quantitate landmark differences to help a Delphi panel converge on a set of landmarks. Methods One hundred percent of anatomic landmark variability across 12 different protocols for manual segmentation was reduced into four segmentation units (the minimum hippocampus, the alveus/fimbria, the tail, and the subiculum), which were segmented on magnetic resonance images by expert raters to estimate reliability and AD-related atrophy. Results Intra- and interrater reliability were more than 0.96 and 0.92, respectively, except for the alveus/fimbria, which were 0.86 and 0.77, respectively. Of all AD-related atrophy, the minimum hippocampus contributed to 67%; tail, 24%; alveus/fimbria, 4%; and the subiculum, 5%. Conclusions Anatomic landmark variability in available protocols can be reduced to four discrete and measurable segmentation units. Their quantitative assessment will help a Delphi panel to define a set of landmarks for a harmonized protocol.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>23706515</pmid><doi>10.1016/j.jalz.2013.03.001</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Aged Alzheimer Disease - pathology Alzheimer's disease Alzheimer's Disease Neuroimaging Initiative Anatomic landmark Atrophy Cognitive Dysfunction - pathology Degeneration Delphi Technique Female Harmonization Hippocampal atrophy Hippocampal volumetry Hippocampus Hippocampus - anatomy & histology Hippocampus - pathology Humans Image Processing, Computer-Assisted - methods Imaging, Three-Dimensional - methods Magnetic resonance Magnetic Resonance Imaging - instrumentation Magnetic Resonance Imaging - methods Male Manual segmentation protocol Manual tracing Medial temporal lobes Neuroimaging Neuroimaging - methods Neurology Organ Size Reproducibility of Results Standard operating procedures |
| title | Operationalizing protocol differences for EADC-ADNI manual hippocampal segmentation |
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