Cognitive aspects of frailty: Mechanisms behind the link between frailty and cognitive impairment
Whereas physical impairment is the main hallmark of frailty, evidence suggests that other dimensions, such as psychological, cognitive and social factors also contribute to this multidimensional condition. Cognition is now considered a relevant domain of frailty. Cognitive and physical frailty inter...
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| Veröffentlicht in: | The Journal of nutrition, health & aging health & aging, 2015-03, Vol.19 (3), p.276-283 |
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| container_title | The Journal of nutrition, health & aging |
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| creator | Halil, M Cemal Kizilarslanoglu, Muhammet Emin Kuyumcu, M Yesil, Y Cruz Jentoft, A. J |
| description | Whereas physical impairment is the main hallmark of frailty, evidence suggests that other dimensions, such as psychological, cognitive and social factors also contribute to this multidimensional condition. Cognition is now considered a relevant domain of frailty. Cognitive and physical frailty interact: cognitive problems and dementia are more prevalent in physically frail individuals, and those with cognitive impairment are more prone to become frail. Disentangling the relationship between cognition and frailty may lead to new intervention strategies for the prevention and treatment of both conditions. Both frailty and cognitive decline share common potential mechanisms. This review examines the relationship between frailty and cognitive decline and explores the role of vascular changes, hormones, vitamin D, inflammation, insulin resistance, and nutrition in the development of physical frailty and cognitive problems, as potential underlying mechanisms behind this link. Dual tasking studies may be a useful way to explore and understand the relation between cognitive and physical frailty. Further studies are needed to elucidate this complex relation to improve the outcomes of frailty. |
| doi_str_mv | 10.1007/s12603-014-0535-z |
| format | Article |
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This review examines the relationship between frailty and cognitive decline and explores the role of vascular changes, hormones, vitamin D, inflammation, insulin resistance, and nutrition in the development of physical frailty and cognitive problems, as potential underlying mechanisms behind this link. Dual tasking studies may be a useful way to explore and understand the relation between cognitive and physical frailty. 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J</creatorcontrib><title>Cognitive aspects of frailty: Mechanisms behind the link between frailty and cognitive impairment</title><title>The Journal of nutrition, health & aging</title><addtitle>J Nutr Health Aging</addtitle><addtitle>J Nutr Health Aging</addtitle><description>Whereas physical impairment is the main hallmark of frailty, evidence suggests that other dimensions, such as psychological, cognitive and social factors also contribute to this multidimensional condition. Cognition is now considered a relevant domain of frailty. Cognitive and physical frailty interact: cognitive problems and dementia are more prevalent in physically frail individuals, and those with cognitive impairment are more prone to become frail. Disentangling the relationship between cognition and frailty may lead to new intervention strategies for the prevention and treatment of both conditions. Both frailty and cognitive decline share common potential mechanisms. 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| identifier | ISSN: 1279-7707 |
| ispartof | The Journal of nutrition, health & aging, 2015-03, Vol.19 (3), p.276-283 |
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| language | eng |
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| source | MEDLINE; SpringerNature Journals; Alma/SFX Local Collection |
| subjects | Age Aged Aging Blood Vessels - pathology cognition Cognition & reasoning Cognition Disorders - complications Cognition Disorders - psychology Cognitive ability Dementia Exercise Frail Elderly - psychology Frailty Gait Geriatrics Geriatrics/Gerontology hormones Hormones - metabolism Humans inflammation Inflammation - complications Insulin Resistance Internal medicine Medicine Medicine & Public Health Neurosciences Nutrition Nutritional Status Primary Care Medicine psychosocial factors Quality of Life Research vitamin D Vitamin D - metabolism |
| title | Cognitive aspects of frailty: Mechanisms behind the link between frailty and cognitive impairment |
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