Effect of Sleeve Gastrectomy on Thyroid Hormone Levels
Background Weight loss in morbidly obese patients is associated with changes in thyroid function. Studies have demonstrated equivalent changes following bariatric surgery. Changes in thyroid function were reported following laparoscopic Roux-en-Y gastric bypass (LRYGB), biliopancreatic diversion (BP...
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| Veröffentlicht in: | Obesity surgery 2015-03, Vol.25 (3), p.452-456 |
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| creator | Abu-Ghanem, Yasmin Inbar, Roy Tyomkin, Vitaly Kent, Ilan Berkovich, Liron Ghinea, Ronen Avital, Shmuel |
| description | Background
Weight loss in morbidly obese patients is associated with changes in thyroid function. Studies have demonstrated equivalent changes following bariatric surgery. Changes in thyroid function were reported following laparoscopic Roux-en-Y gastric bypass (LRYGB), biliopancreatic diversion (BPD), and laparoscopic adjustable gastric banding (LAGB). No data exists on changes in thyroid function following laparoscopic sleeve gastrectomy (LSG). The aim of the current study is to evaluate changes in thyroid function following LSG in patients with normal thyroid function.
Methods
Data were retrieved from a prospectively collected database of patients who underwent LSG for morbid obesity. Euthyroid patients were evaluated for changes in TSH and free thyroxine (FT4), 6–12 months after surgery. Correlation between changes in thyroid hormone levels, excess weight loss (EWL), and baseline TSH were evaluated.
Results
Thirty-eight patients were included in the study. Mean BMI decreased from 42.4 to 32.5 kg/m
2
(
P
|
| doi_str_mv | 10.1007/s11695-014-1415-7 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1660652430</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1660652430</sourcerecordid><originalsourceid>FETCH-LOGICAL-c508t-e2bc55e60da4a3e0f16e222684329434bbe83222be731470d3b9188a38983a113</originalsourceid><addsrcrecordid>eNp1kMFKAzEQhoMotlYfwIssePGyOpNkk-xRpLZCwYP1HHa3s9qyu6lJV-jbm9IqIngamPnmn-Fj7BLhFgH0XUBUeZYCyhQlZqk-YkPUYFKQ3ByzIeQKUpNzMWBnIawAOCrOT9mAZ6i50HLI1Liuqdokrk5eGqJPSiZF2PjYcu02cV0yf996t1wkU-db11Eyi0wTztlJXTSBLg51xF4fx_OHaTp7njw93M_SKgOzSYmXVZaRgkUhC0FQoyLOuTJS8FwKWZZkRGyUpAVKDQtR5mhMIUxuRIEoRuxmn7v27qOnsLHtMlTUNEVHrg8WlQKVcSkgotd_0JXrfRe_i1SWm1zpGDpiuKcq70LwVNu1X7aF31oEu5Nq91JtlGp3Uq2OO1eH5L5safGz8W0xAnwPhDjq3sj_Ov1v6hfnIX6F</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1659896798</pqid></control><display><type>article</type><title>Effect of Sleeve Gastrectomy on Thyroid Hormone Levels</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><creator>Abu-Ghanem, Yasmin ; Inbar, Roy ; Tyomkin, Vitaly ; Kent, Ilan ; Berkovich, Liron ; Ghinea, Ronen ; Avital, Shmuel</creator><creatorcontrib>Abu-Ghanem, Yasmin ; Inbar, Roy ; Tyomkin, Vitaly ; Kent, Ilan ; Berkovich, Liron ; Ghinea, Ronen ; Avital, Shmuel</creatorcontrib><description>Background
Weight loss in morbidly obese patients is associated with changes in thyroid function. Studies have demonstrated equivalent changes following bariatric surgery. Changes in thyroid function were reported following laparoscopic Roux-en-Y gastric bypass (LRYGB), biliopancreatic diversion (BPD), and laparoscopic adjustable gastric banding (LAGB). No data exists on changes in thyroid function following laparoscopic sleeve gastrectomy (LSG). The aim of the current study is to evaluate changes in thyroid function following LSG in patients with normal thyroid function.
Methods
Data were retrieved from a prospectively collected database of patients who underwent LSG for morbid obesity. Euthyroid patients were evaluated for changes in TSH and free thyroxine (FT4), 6–12 months after surgery. Correlation between changes in thyroid hormone levels, excess weight loss (EWL), and baseline TSH were evaluated.
Results
Thirty-eight patients were included in the study. Mean BMI decreased from 42.4 to 32.5 kg/m
2
(
P
< 0.0001). Mean TSH levels decreased from 2.45 ± 0.17 mU/L at baseline to 1.82 ± 0.18 mU/L (
P
< 0.0001), whereas mean FT4 levels remained the same after surgery (13.27 ± 0.45 pmol/L compared to 12.96 ± 0.42 pmol/L,
P
= NS). TSH decrease was directly related to baseline TSH but did not correlate with EWL.
Conclusions
This is the first study to evaluate changes in thyroid hormone levels following LSG for morbid obesity. TSH decrease and steady levels of FT4 are expected following LSG. These findings are comparable to reported changes following LRYGB. TSH decrease was not associated with EWL. Further studies are required to elucidate the exact mechanism of this effect.</description><identifier>ISSN: 0960-8923</identifier><identifier>EISSN: 1708-0428</identifier><identifier>DOI: 10.1007/s11695-014-1415-7</identifier><identifier>PMID: 25172374</identifier><language>eng</language><publisher>Boston: Springer US</publisher><subject>Adult ; Biliopancreatic Diversion ; Female ; Gastrectomy - methods ; Gastric Bypass ; Gastrointestinal surgery ; Hormones ; Humans ; Laparoscopy - methods ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Obesity ; Obesity, Morbid - blood ; Obesity, Morbid - surgery ; Original Contributions ; Surgery ; Thyroid gland ; Thyroid Hormones - blood ; Thyrotropin - blood ; Weight control ; Weight Loss - physiology ; Young Adult</subject><ispartof>Obesity surgery, 2015-03, Vol.25 (3), p.452-456</ispartof><rights>Springer Science+Business Media New York 2014</rights><rights>Springer Science+Business Media New York 2015</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c508t-e2bc55e60da4a3e0f16e222684329434bbe83222be731470d3b9188a38983a113</citedby><cites>FETCH-LOGICAL-c508t-e2bc55e60da4a3e0f16e222684329434bbe83222be731470d3b9188a38983a113</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11695-014-1415-7$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11695-014-1415-7$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25172374$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Abu-Ghanem, Yasmin</creatorcontrib><creatorcontrib>Inbar, Roy</creatorcontrib><creatorcontrib>Tyomkin, Vitaly</creatorcontrib><creatorcontrib>Kent, Ilan</creatorcontrib><creatorcontrib>Berkovich, Liron</creatorcontrib><creatorcontrib>Ghinea, Ronen</creatorcontrib><creatorcontrib>Avital, Shmuel</creatorcontrib><title>Effect of Sleeve Gastrectomy on Thyroid Hormone Levels</title><title>Obesity surgery</title><addtitle>OBES SURG</addtitle><addtitle>Obes Surg</addtitle><description>Background
Weight loss in morbidly obese patients is associated with changes in thyroid function. Studies have demonstrated equivalent changes following bariatric surgery. Changes in thyroid function were reported following laparoscopic Roux-en-Y gastric bypass (LRYGB), biliopancreatic diversion (BPD), and laparoscopic adjustable gastric banding (LAGB). No data exists on changes in thyroid function following laparoscopic sleeve gastrectomy (LSG). The aim of the current study is to evaluate changes in thyroid function following LSG in patients with normal thyroid function.
Methods
Data were retrieved from a prospectively collected database of patients who underwent LSG for morbid obesity. Euthyroid patients were evaluated for changes in TSH and free thyroxine (FT4), 6–12 months after surgery. Correlation between changes in thyroid hormone levels, excess weight loss (EWL), and baseline TSH were evaluated.
Results
Thirty-eight patients were included in the study. Mean BMI decreased from 42.4 to 32.5 kg/m
2
(
P
< 0.0001). Mean TSH levels decreased from 2.45 ± 0.17 mU/L at baseline to 1.82 ± 0.18 mU/L (
P
< 0.0001), whereas mean FT4 levels remained the same after surgery (13.27 ± 0.45 pmol/L compared to 12.96 ± 0.42 pmol/L,
P
= NS). TSH decrease was directly related to baseline TSH but did not correlate with EWL.
Conclusions
This is the first study to evaluate changes in thyroid hormone levels following LSG for morbid obesity. TSH decrease and steady levels of FT4 are expected following LSG. These findings are comparable to reported changes following LRYGB. TSH decrease was not associated with EWL. Further studies are required to elucidate the exact mechanism of this effect.</description><subject>Adult</subject><subject>Biliopancreatic Diversion</subject><subject>Female</subject><subject>Gastrectomy - methods</subject><subject>Gastric Bypass</subject><subject>Gastrointestinal surgery</subject><subject>Hormones</subject><subject>Humans</subject><subject>Laparoscopy - methods</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Obesity</subject><subject>Obesity, Morbid - blood</subject><subject>Obesity, Morbid - surgery</subject><subject>Original Contributions</subject><subject>Surgery</subject><subject>Thyroid gland</subject><subject>Thyroid Hormones - blood</subject><subject>Thyrotropin - blood</subject><subject>Weight control</subject><subject>Weight Loss - physiology</subject><subject>Young Adult</subject><issn>0960-8923</issn><issn>1708-0428</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kMFKAzEQhoMotlYfwIssePGyOpNkk-xRpLZCwYP1HHa3s9qyu6lJV-jbm9IqIngamPnmn-Fj7BLhFgH0XUBUeZYCyhQlZqk-YkPUYFKQ3ByzIeQKUpNzMWBnIawAOCrOT9mAZ6i50HLI1Liuqdokrk5eGqJPSiZF2PjYcu02cV0yf996t1wkU-db11Eyi0wTztlJXTSBLg51xF4fx_OHaTp7njw93M_SKgOzSYmXVZaRgkUhC0FQoyLOuTJS8FwKWZZkRGyUpAVKDQtR5mhMIUxuRIEoRuxmn7v27qOnsLHtMlTUNEVHrg8WlQKVcSkgotd_0JXrfRe_i1SWm1zpGDpiuKcq70LwVNu1X7aF31oEu5Nq91JtlGp3Uq2OO1eH5L5safGz8W0xAnwPhDjq3sj_Ov1v6hfnIX6F</recordid><startdate>20150301</startdate><enddate>20150301</enddate><creator>Abu-Ghanem, Yasmin</creator><creator>Inbar, Roy</creator><creator>Tyomkin, Vitaly</creator><creator>Kent, Ilan</creator><creator>Berkovich, Liron</creator><creator>Ghinea, Ronen</creator><creator>Avital, Shmuel</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20150301</creationdate><title>Effect of Sleeve Gastrectomy on Thyroid Hormone Levels</title><author>Abu-Ghanem, Yasmin ; Inbar, Roy ; Tyomkin, Vitaly ; Kent, Ilan ; Berkovich, Liron ; Ghinea, Ronen ; Avital, Shmuel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c508t-e2bc55e60da4a3e0f16e222684329434bbe83222be731470d3b9188a38983a113</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adult</topic><topic>Biliopancreatic Diversion</topic><topic>Female</topic><topic>Gastrectomy - methods</topic><topic>Gastric Bypass</topic><topic>Gastrointestinal surgery</topic><topic>Hormones</topic><topic>Humans</topic><topic>Laparoscopy - methods</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Obesity</topic><topic>Obesity, Morbid - blood</topic><topic>Obesity, Morbid - surgery</topic><topic>Original Contributions</topic><topic>Surgery</topic><topic>Thyroid gland</topic><topic>Thyroid Hormones - blood</topic><topic>Thyrotropin - blood</topic><topic>Weight control</topic><topic>Weight Loss - physiology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Abu-Ghanem, Yasmin</creatorcontrib><creatorcontrib>Inbar, Roy</creatorcontrib><creatorcontrib>Tyomkin, Vitaly</creatorcontrib><creatorcontrib>Kent, Ilan</creatorcontrib><creatorcontrib>Berkovich, Liron</creatorcontrib><creatorcontrib>Ghinea, Ronen</creatorcontrib><creatorcontrib>Avital, Shmuel</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Obesity surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Abu-Ghanem, Yasmin</au><au>Inbar, Roy</au><au>Tyomkin, Vitaly</au><au>Kent, Ilan</au><au>Berkovich, Liron</au><au>Ghinea, Ronen</au><au>Avital, Shmuel</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of Sleeve Gastrectomy on Thyroid Hormone Levels</atitle><jtitle>Obesity surgery</jtitle><stitle>OBES SURG</stitle><addtitle>Obes Surg</addtitle><date>2015-03-01</date><risdate>2015</risdate><volume>25</volume><issue>3</issue><spage>452</spage><epage>456</epage><pages>452-456</pages><issn>0960-8923</issn><eissn>1708-0428</eissn><abstract>Background
Weight loss in morbidly obese patients is associated with changes in thyroid function. Studies have demonstrated equivalent changes following bariatric surgery. Changes in thyroid function were reported following laparoscopic Roux-en-Y gastric bypass (LRYGB), biliopancreatic diversion (BPD), and laparoscopic adjustable gastric banding (LAGB). No data exists on changes in thyroid function following laparoscopic sleeve gastrectomy (LSG). The aim of the current study is to evaluate changes in thyroid function following LSG in patients with normal thyroid function.
Methods
Data were retrieved from a prospectively collected database of patients who underwent LSG for morbid obesity. Euthyroid patients were evaluated for changes in TSH and free thyroxine (FT4), 6–12 months after surgery. Correlation between changes in thyroid hormone levels, excess weight loss (EWL), and baseline TSH were evaluated.
Results
Thirty-eight patients were included in the study. Mean BMI decreased from 42.4 to 32.5 kg/m
2
(
P
< 0.0001). Mean TSH levels decreased from 2.45 ± 0.17 mU/L at baseline to 1.82 ± 0.18 mU/L (
P
< 0.0001), whereas mean FT4 levels remained the same after surgery (13.27 ± 0.45 pmol/L compared to 12.96 ± 0.42 pmol/L,
P
= NS). TSH decrease was directly related to baseline TSH but did not correlate with EWL.
Conclusions
This is the first study to evaluate changes in thyroid hormone levels following LSG for morbid obesity. TSH decrease and steady levels of FT4 are expected following LSG. These findings are comparable to reported changes following LRYGB. TSH decrease was not associated with EWL. Further studies are required to elucidate the exact mechanism of this effect.</abstract><cop>Boston</cop><pub>Springer US</pub><pmid>25172374</pmid><doi>10.1007/s11695-014-1415-7</doi><tpages>5</tpages></addata></record> |
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| ispartof | Obesity surgery, 2015-03, Vol.25 (3), p.452-456 |
| issn | 0960-8923 1708-0428 |
| language | eng |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Adult Biliopancreatic Diversion Female Gastrectomy - methods Gastric Bypass Gastrointestinal surgery Hormones Humans Laparoscopy - methods Male Medicine Medicine & Public Health Middle Aged Obesity Obesity, Morbid - blood Obesity, Morbid - surgery Original Contributions Surgery Thyroid gland Thyroid Hormones - blood Thyrotropin - blood Weight control Weight Loss - physiology Young Adult |
| title | Effect of Sleeve Gastrectomy on Thyroid Hormone Levels |
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