Liquid holding effects on methylmercury genotoxicity in human lymphocytes

Liquid holding effects on methylmercury genotoxicity in human lymphocytes

Methylmercury chloride (MMC) treatment of resting (GO) human lymphocytes resulted in the formation of chromosome and chromatid aberrations. This treatment also induced aneuploidy in second metaphases, suggesting that MMC produces stable damage involved in chromosome segregation errors. The storage o...

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Veröffentlicht in:Mutation research 1993-04, Vol.301 (4), p.267-273
Hauptverfasser: Betti, C., Davini, T., He, J., Barale, R.
Format: Artikel
Sprache:eng
Schlagworte:
Aneuploidy
Biological and medical sciences
Chemical mutagenesis
Chromosome Aberrations
Cytological Techniques
dimethylmercury
DNA Damage
DNA Repair
genotoxicity
Humans
Hyperdiploidy
Hypotonic Solutions
Liquid holding
lymphocytes
Lymphocytes - drug effects
Male
man
Medical sciences
Metaphase - drug effects
Methylmercury chloride
Methylmercury Compounds - toxicity
Middle Aged
Mitosis - drug effects
Mutagens - toxicity
Resting Phase, Cell Cycle - drug effects
Sister Chromatid Exchange
Toxicology
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Zusammenfassung:Methylmercury chloride (MMC) treatment of resting (GO) human lymphocytes resulted in the formation of chromosome and chromatid aberrations. This treatment also induced aneuploidy in second metaphases, suggesting that MMC produces stable damage involved in chromosome segregation errors. The storage of treated cells (liquid holding for 48 h before cell proliferation) did not result in an important recovery from induced cell toxicity or chromosome damage. Therefore, MMC seems to be an X-ray-like agent, able to produce long-lasting damages giving rise to both structural and numerical chromosome abnormalities.
ISSN:0165-7992
0027-5107
DOI:10.1016/0165-7992(93)90068-7