Investigation of the Interactions of Silibinin with 2‑Hydroxypropyl-β-cyclodextrin through Biophysical Techniques and Computational Methods

Cyclodextrins (CDs) are a well-known class of supermolecules that have been widely used to protect drugs against conjugation and metabolic inactivation as well as to enhance the aqueous solubility and hence to ameliorate the oral bioavailability of sparingly soluble drug molecules. The hepatoprotect...

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Veröffentlicht in:Molecular pharmaceutics 2015-03, Vol.12 (3), p.954-965
Hauptverfasser: Kellici, Tahsin F, Ntountaniotis, Dimitrios, Leonis, Georgios, Chatziathanasiadou, Maria, Chatzikonstantinou, Alexandra V, Becker-Baldus, Johanna, Glaubitz, Clemens, Tzakos, Andreas G, Viras, Kyriakos, Chatzigeorgiou, Petros, Tzimas, Stavros, Kefala, Evangelia, Valsami, Georgia, Archontaki, Helen, Papadopoulos, Manthos G, Mavromoustakos, Thomas
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Sprache:eng
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