Glutamate presynaptic vesicular transporter and postsynaptic receptor levels correlate with spatial memory status in aging rat models

Abstract In humans, memory capacities are generally affected with aging, even without any reported neurologic disorders. The mechanisms behind cognitive decline are not well understood. We studied here whether postsynaptic glutamate receptor and presynaptic vesicular glutamate transporters (VGLUTs)...

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Veröffentlicht in:	Neurobiology of aging 2015-03, Vol.36 (3), p.1471-1482
Hauptverfasser:	Ménard, Caroline, Quirion, Rémi, Vigneault, Erika, Bouchard, Sylvain, Ferland, Guylaine, El Mestikawy, Salah, Gaudreau, Pierrette
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Aging - psychology AMPA Animals Biomarkers - metabolism Cerebral Cortex - metabolism Cognition Disorders - diagnosis Female Gene Expression - genetics Glutamate receptors Hippocampus - metabolism Internal Medicine Male mGluR Models, Animal Neurology NMDA Rats, Inbred Strains Rats, Long-Evans Receptors, AMPA - genetics Receptors, AMPA - metabolism Receptors, N-Methyl-D-Aspartate - genetics Receptors, N-Methyl-D-Aspartate - metabolism Spatial memory Spatial Memory - physiology Vesicular Glutamate Transport Protein 1 - genetics Vesicular Glutamate Transport Protein 1 - metabolism Vesicular Glutamate Transport Protein 2 - genetics Vesicular Glutamate Transport Protein 2 - metabolism VGLUT
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