Hypocretin (orexin) biology and the pathophysiology of narcolepsy with cataplexy

Summary The discovery of hypocretins (orexins) and their causal implication in narcolepsy is the most important advance in sleep research and sleep medicine since the discovery of rapid eye movement sleep. Narcolepsy with cataplexy is caused by hypocretin deficiency owing to destruction of most of t...

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Veröffentlicht in:	Lancet neurology 2015-03, Vol.14 (3), p.318-328
Hauptverfasser:	Liblau, Roland S, Prof, Vassalli, Anne, PhD, Seifinejad, Ali, MSc, Tafti, Mehdi, Prof
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Behavior Brain - immunology Brain - physiopathology Cataplexy - genetics Cataplexy - immunology Cataplexy - physiopathology Diabetes Food Genes Genetics Humans Intracellular Signaling Peptides and Proteins - genetics Intracellular Signaling Peptides and Proteins - immunology Metabolism Metabolites Mutation Narcolepsy - genetics Narcolepsy - immunology Narcolepsy - physiopathology Nerve Net - immunology Nerve Net - physiopathology Neurology Neurons Neuropeptides - genetics Neuropeptides - immunology Orexins
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