Association of paraoxonase (PON)1 activity, glutathione S-transferase GST T1/M1 and STin.2 polymorphisms with comorbidity of tobacco use disorder and mood disorders
•We examine the biological underpinnings of comorbid mood and tobacco use disorder (TUD).•Comorbid TUD and mood disorders are associated with lower paraoxonase 1 activity.•This comorbidity is associated with the STin2.10/10 genotype and STin2.12 allele.•This comorbidity is associated with the glutat...
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| Veröffentlicht in: | Neuroscience letters 2015-01, Vol.585, p.132-137 |
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| creator | Vargas Nunes, Sandra Odebrecht Pizzo de Castro, Márcia Regina Moreira, Estefania Gastaldello Guembarovski, Roberta Losi Barbosa, Decio Sabbatini Vargas, Heber Odebrecht Piccoli de Melo, Luiz Gustavo Bortolasci, Chiara Cristina Watanabe, Maria Angelica Ehara Dodd, Seetal Berk, Michael Maes, Michael |
| description | •We examine the biological underpinnings of comorbid mood and tobacco use disorder (TUD).•Comorbid TUD and mood disorders are associated with lower paraoxonase 1 activity.•This comorbidity is associated with the STin2.10/10 genotype and STin2.12 allele.•This comorbidity is associated with the glutathione-S-transferase T1/M1 null genotype.•The comorbidity is associated with oxidative and serotonin signaling pathways.
There is evidence that genetic factors influence the probability of comorbidity of tobacco use disorder (TUD) with mood disorders.
This study was carried out to examine whether both TUD and mood disorders are associated with genetic biomarkers particularly paraoxonase 1 (PON1) status, polymorphisms of glutathione S-transferases (GSTs), such as GSTM1 and GSTT1, and the STIn 2 polymorphism of the serotonin transporter.
PON1 status (Q192R polymorphism and PON1 plasmatic activity), GSTM1, GSTT1, and STin.2 genotypes and alleles were assayed in 4 mutually exclusive study groups, i.e., comorbid mood disorder and TUD (n=95); TUD without mood disorders (n=90); mood disorders but no TUD (n=62); and controls (never-smokers without mood disorders; n=113).
Logistic regression analyses showed that comorbid mood disorders and TUD were associated with significantly lower PON1 activity, the STin2.10/10 genotype (protective) or the Stin2.12 allele (risk factor) and the GSTM1 and GSTT1 null genotypes (protective).
These results show that comorbid mood disorders and TUD are associated with specific biomarkers related to oxidative stress and serotonin pathways. |
| doi_str_mv | 10.1016/j.neulet.2014.11.002 |
| format | Article |
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There is evidence that genetic factors influence the probability of comorbidity of tobacco use disorder (TUD) with mood disorders.
This study was carried out to examine whether both TUD and mood disorders are associated with genetic biomarkers particularly paraoxonase 1 (PON1) status, polymorphisms of glutathione S-transferases (GSTs), such as GSTM1 and GSTT1, and the STIn 2 polymorphism of the serotonin transporter.
PON1 status (Q192R polymorphism and PON1 plasmatic activity), GSTM1, GSTT1, and STin.2 genotypes and alleles were assayed in 4 mutually exclusive study groups, i.e., comorbid mood disorder and TUD (n=95); TUD without mood disorders (n=90); mood disorders but no TUD (n=62); and controls (never-smokers without mood disorders; n=113).
Logistic regression analyses showed that comorbid mood disorders and TUD were associated with significantly lower PON1 activity, the STin2.10/10 genotype (protective) or the Stin2.12 allele (risk factor) and the GSTM1 and GSTT1 null genotypes (protective).
These results show that comorbid mood disorders and TUD are associated with specific biomarkers related to oxidative stress and serotonin pathways.</description><identifier>ISSN: 0304-3940</identifier><identifier>EISSN: 1872-7972</identifier><identifier>DOI: 10.1016/j.neulet.2014.11.002</identifier><identifier>PMID: 25445355</identifier><language>eng</language><publisher>Ireland: Elsevier Ireland Ltd</publisher><subject>Adolescent ; Adult ; Aged ; Aryldialkylphosphatase - metabolism ; Case-Control Studies ; Comorbidity ; Depression ; Female ; Genetic ; Genetic Association Studies ; Glutathione Transferase - genetics ; Humans ; Male ; Middle Aged ; Mood disorders ; Mood Disorders - epidemiology ; Mood Disorders - genetics ; Mood Disorders - metabolism ; Oxidative stress ; Polymorphism ; Polymorphism, Genetic ; Serotonin ; Serotonin Plasma Membrane Transport Proteins - genetics ; Tobacco use disorder ; Tobacco Use Disorder - epidemiology ; Tobacco Use Disorder - genetics ; Tobacco Use Disorder - metabolism ; Young Adult</subject><ispartof>Neuroscience letters, 2015-01, Vol.585, p.132-137</ispartof><rights>2014 Elsevier Ireland Ltd</rights><rights>Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c395t-eb2a9faf9472b26866cfb0d3d492fc2573ef17bd86db543cbddb602074afdd1d3</citedby><cites>FETCH-LOGICAL-c395t-eb2a9faf9472b26866cfb0d3d492fc2573ef17bd86db543cbddb602074afdd1d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.neulet.2014.11.002$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25445355$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Vargas Nunes, Sandra Odebrecht</creatorcontrib><creatorcontrib>Pizzo de Castro, Márcia Regina</creatorcontrib><creatorcontrib>Moreira, Estefania Gastaldello</creatorcontrib><creatorcontrib>Guembarovski, Roberta Losi</creatorcontrib><creatorcontrib>Barbosa, Decio Sabbatini</creatorcontrib><creatorcontrib>Vargas, Heber Odebrecht</creatorcontrib><creatorcontrib>Piccoli de Melo, Luiz Gustavo</creatorcontrib><creatorcontrib>Bortolasci, Chiara Cristina</creatorcontrib><creatorcontrib>Watanabe, Maria Angelica Ehara</creatorcontrib><creatorcontrib>Dodd, Seetal</creatorcontrib><creatorcontrib>Berk, Michael</creatorcontrib><creatorcontrib>Maes, Michael</creatorcontrib><title>Association of paraoxonase (PON)1 activity, glutathione S-transferase GST T1/M1 and STin.2 polymorphisms with comorbidity of tobacco use disorder and mood disorders</title><title>Neuroscience letters</title><addtitle>Neurosci Lett</addtitle><description>•We examine the biological underpinnings of comorbid mood and tobacco use disorder (TUD).•Comorbid TUD and mood disorders are associated with lower paraoxonase 1 activity.•This comorbidity is associated with the STin2.10/10 genotype and STin2.12 allele.•This comorbidity is associated with the glutathione-S-transferase T1/M1 null genotype.•The comorbidity is associated with oxidative and serotonin signaling pathways.
There is evidence that genetic factors influence the probability of comorbidity of tobacco use disorder (TUD) with mood disorders.
This study was carried out to examine whether both TUD and mood disorders are associated with genetic biomarkers particularly paraoxonase 1 (PON1) status, polymorphisms of glutathione S-transferases (GSTs), such as GSTM1 and GSTT1, and the STIn 2 polymorphism of the serotonin transporter.
PON1 status (Q192R polymorphism and PON1 plasmatic activity), GSTM1, GSTT1, and STin.2 genotypes and alleles were assayed in 4 mutually exclusive study groups, i.e., comorbid mood disorder and TUD (n=95); TUD without mood disorders (n=90); mood disorders but no TUD (n=62); and controls (never-smokers without mood disorders; n=113).
Logistic regression analyses showed that comorbid mood disorders and TUD were associated with significantly lower PON1 activity, the STin2.10/10 genotype (protective) or the Stin2.12 allele (risk factor) and the GSTM1 and GSTT1 null genotypes (protective).
These results show that comorbid mood disorders and TUD are associated with specific biomarkers related to oxidative stress and serotonin pathways.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aryldialkylphosphatase - metabolism</subject><subject>Case-Control Studies</subject><subject>Comorbidity</subject><subject>Depression</subject><subject>Female</subject><subject>Genetic</subject><subject>Genetic Association Studies</subject><subject>Glutathione Transferase - genetics</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Mood disorders</subject><subject>Mood Disorders - epidemiology</subject><subject>Mood Disorders - genetics</subject><subject>Mood Disorders - metabolism</subject><subject>Oxidative stress</subject><subject>Polymorphism</subject><subject>Polymorphism, Genetic</subject><subject>Serotonin</subject><subject>Serotonin Plasma Membrane Transport Proteins - genetics</subject><subject>Tobacco use disorder</subject><subject>Tobacco Use Disorder - epidemiology</subject><subject>Tobacco Use Disorder - genetics</subject><subject>Tobacco Use Disorder - metabolism</subject><subject>Young Adult</subject><issn>0304-3940</issn><issn>1872-7972</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kdtq3DAQhkVpaLZp36AUXSZQO5Is2-ubQghtWsgJdnstdBh1tdiWK8lp933yoNF201z2amD45v8ZPoQ-UFJSQpvzbTnC3EMqGaG8pLQkhL1CC7psWdF2LXuNFqQivKg6To7R2xi3hJCa1vwNOmY153VV1wv0eBGj104m50fsLZ5kkP6PH2UEfHp_d3tGsdTJPbi0-4R_9nOSaZNRwKsiBTlGC2GPXq3WeE3PbzI9Grxau7FkePL9bvBh2rg4RPzbpQ3WPi-UMzlu35a8klp7POcI46IPBsLfhMF787KJ79CRlX2E98_zBP34-mV9-a24vrv6fnlxXeiqq1MBisnOStvxlinWLJtGW0VMZXjHrGZ1W4GlrTLLxqiaV1oZoxrCSMulNYaa6gSdHnKn4H_NEJMYXNTQ93IEP0dBm4bwqiVkmVF-QHXwMQawYgpukGEnKBF7P2IrDn7E3o-gVGQ_-ezjc8OsBjAvR_-EZODzAYD854ODIKJ2MGowLoBOwnj3_4YnyjamNA</recordid><startdate>20150112</startdate><enddate>20150112</enddate><creator>Vargas Nunes, Sandra Odebrecht</creator><creator>Pizzo de Castro, Márcia Regina</creator><creator>Moreira, Estefania Gastaldello</creator><creator>Guembarovski, Roberta Losi</creator><creator>Barbosa, Decio Sabbatini</creator><creator>Vargas, Heber Odebrecht</creator><creator>Piccoli de Melo, Luiz Gustavo</creator><creator>Bortolasci, Chiara Cristina</creator><creator>Watanabe, Maria Angelica Ehara</creator><creator>Dodd, Seetal</creator><creator>Berk, Michael</creator><creator>Maes, Michael</creator><general>Elsevier Ireland Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope></search><sort><creationdate>20150112</creationdate><title>Association of paraoxonase (PON)1 activity, glutathione S-transferase GST T1/M1 and STin.2 polymorphisms with comorbidity of tobacco use disorder and mood disorders</title><author>Vargas Nunes, Sandra Odebrecht ; Pizzo de Castro, Márcia Regina ; Moreira, Estefania Gastaldello ; Guembarovski, Roberta Losi ; Barbosa, Decio Sabbatini ; Vargas, Heber Odebrecht ; Piccoli de Melo, Luiz Gustavo ; Bortolasci, Chiara Cristina ; Watanabe, Maria Angelica Ehara ; Dodd, Seetal ; Berk, Michael ; Maes, Michael</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c395t-eb2a9faf9472b26866cfb0d3d492fc2573ef17bd86db543cbddb602074afdd1d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aryldialkylphosphatase - metabolism</topic><topic>Case-Control Studies</topic><topic>Comorbidity</topic><topic>Depression</topic><topic>Female</topic><topic>Genetic</topic><topic>Genetic Association Studies</topic><topic>Glutathione Transferase - genetics</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Mood disorders</topic><topic>Mood Disorders - epidemiology</topic><topic>Mood Disorders - genetics</topic><topic>Mood Disorders - metabolism</topic><topic>Oxidative stress</topic><topic>Polymorphism</topic><topic>Polymorphism, Genetic</topic><topic>Serotonin</topic><topic>Serotonin Plasma Membrane Transport Proteins - genetics</topic><topic>Tobacco use disorder</topic><topic>Tobacco Use Disorder - epidemiology</topic><topic>Tobacco Use Disorder - genetics</topic><topic>Tobacco Use Disorder - metabolism</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Vargas Nunes, Sandra Odebrecht</creatorcontrib><creatorcontrib>Pizzo de Castro, Márcia Regina</creatorcontrib><creatorcontrib>Moreira, Estefania Gastaldello</creatorcontrib><creatorcontrib>Guembarovski, Roberta Losi</creatorcontrib><creatorcontrib>Barbosa, Decio Sabbatini</creatorcontrib><creatorcontrib>Vargas, Heber Odebrecht</creatorcontrib><creatorcontrib>Piccoli de Melo, Luiz Gustavo</creatorcontrib><creatorcontrib>Bortolasci, Chiara Cristina</creatorcontrib><creatorcontrib>Watanabe, Maria Angelica Ehara</creatorcontrib><creatorcontrib>Dodd, Seetal</creatorcontrib><creatorcontrib>Berk, Michael</creatorcontrib><creatorcontrib>Maes, Michael</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><jtitle>Neuroscience letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Vargas Nunes, Sandra Odebrecht</au><au>Pizzo de Castro, Márcia Regina</au><au>Moreira, Estefania Gastaldello</au><au>Guembarovski, Roberta Losi</au><au>Barbosa, Decio Sabbatini</au><au>Vargas, Heber Odebrecht</au><au>Piccoli de Melo, Luiz Gustavo</au><au>Bortolasci, Chiara Cristina</au><au>Watanabe, Maria Angelica Ehara</au><au>Dodd, Seetal</au><au>Berk, Michael</au><au>Maes, Michael</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of paraoxonase (PON)1 activity, glutathione S-transferase GST T1/M1 and STin.2 polymorphisms with comorbidity of tobacco use disorder and mood disorders</atitle><jtitle>Neuroscience letters</jtitle><addtitle>Neurosci Lett</addtitle><date>2015-01-12</date><risdate>2015</risdate><volume>585</volume><spage>132</spage><epage>137</epage><pages>132-137</pages><issn>0304-3940</issn><eissn>1872-7972</eissn><abstract>•We examine the biological underpinnings of comorbid mood and tobacco use disorder (TUD).•Comorbid TUD and mood disorders are associated with lower paraoxonase 1 activity.•This comorbidity is associated with the STin2.10/10 genotype and STin2.12 allele.•This comorbidity is associated with the glutathione-S-transferase T1/M1 null genotype.•The comorbidity is associated with oxidative and serotonin signaling pathways.
There is evidence that genetic factors influence the probability of comorbidity of tobacco use disorder (TUD) with mood disorders.
This study was carried out to examine whether both TUD and mood disorders are associated with genetic biomarkers particularly paraoxonase 1 (PON1) status, polymorphisms of glutathione S-transferases (GSTs), such as GSTM1 and GSTT1, and the STIn 2 polymorphism of the serotonin transporter.
PON1 status (Q192R polymorphism and PON1 plasmatic activity), GSTM1, GSTT1, and STin.2 genotypes and alleles were assayed in 4 mutually exclusive study groups, i.e., comorbid mood disorder and TUD (n=95); TUD without mood disorders (n=90); mood disorders but no TUD (n=62); and controls (never-smokers without mood disorders; n=113).
Logistic regression analyses showed that comorbid mood disorders and TUD were associated with significantly lower PON1 activity, the STin2.10/10 genotype (protective) or the Stin2.12 allele (risk factor) and the GSTM1 and GSTT1 null genotypes (protective).
These results show that comorbid mood disorders and TUD are associated with specific biomarkers related to oxidative stress and serotonin pathways.</abstract><cop>Ireland</cop><pub>Elsevier Ireland Ltd</pub><pmid>25445355</pmid><doi>10.1016/j.neulet.2014.11.002</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0304-3940 |
| ispartof | Neuroscience letters, 2015-01, Vol.585, p.132-137 |
| issn | 0304-3940 1872-7972 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1660437008 |
| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Adolescent Adult Aged Aryldialkylphosphatase - metabolism Case-Control Studies Comorbidity Depression Female Genetic Genetic Association Studies Glutathione Transferase - genetics Humans Male Middle Aged Mood disorders Mood Disorders - epidemiology Mood Disorders - genetics Mood Disorders - metabolism Oxidative stress Polymorphism Polymorphism, Genetic Serotonin Serotonin Plasma Membrane Transport Proteins - genetics Tobacco use disorder Tobacco Use Disorder - epidemiology Tobacco Use Disorder - genetics Tobacco Use Disorder - metabolism Young Adult |
| title | Association of paraoxonase (PON)1 activity, glutathione S-transferase GST T1/M1 and STin.2 polymorphisms with comorbidity of tobacco use disorder and mood disorders |
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