A lentiviral sponge for miRNA-21 diminishes aerobic glycolysis in bladder cancer T24 cells via the PTEN/PI3K/AKT/mTOR axis

Cancer cells exhibit the ability to metabolise glucose to lactate even under aerobic conditions for energy. This phenomenon is known as the Warburg effect and can be a potential target to kill cancer cells. Several studies have shown evidence for interplay between microRNAs and key metabolic enzyme...

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Veröffentlicht in:	Tumor biology 2015-01, Vol.36 (1), p.383-391
Hauptverfasser:	Yang, Xiao, Cheng, Yidong, Li, Pengchao, Tao, Jun, Deng, Xiaheng, Zhang, Xiaolei, Gu, Min, Lu, Qiang, Yin, Changjun
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomedical and Life Sciences Biomedicine Cancer Cancer Research Cell Line, Tumor Cells Gene Expression Gene Expression Regulation, Neoplastic Gene Knockdown Techniques Glucose - metabolism Glycolysis Glycosylation Humans Lentivirus MicroRNAs - genetics MicroRNAs - metabolism Phosphatidylinositol 3-Kinases - metabolism Proto-Oncogene Proteins c-akt - metabolism PTEN Phosphohydrolase - metabolism Research Article Ribonucleic acid RNA Signal Transduction TOR Serine-Threonine Kinases - metabolism Transduction, Genetic Urinary Bladder Neoplasms
Online-Zugang:	Volltext
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