Comparison between T1 relaxation time of Gd-EOB-DTPA-enhanced MRI and liver stiffness measurement of ultrasound elastography in the evaluation of cirrhotic liver
Purpose To compare four imaging approaches in cirrhotic estimation; pre‐enhancement T1 relaxation time (T1RT), reduction rate (RR) of T1RT, signal‐based liver‐to‐muscle ratio (L/M ratio) on gadolinium ethoxybenzyl diethylenetriaminepentaacetic acid (Gd‐EOB‐DTPA)‐enhanced magnetic resonance imaging (...
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creator | Okada, Masahiro Murakami, Takamichi Yada, Norihisa Numata, Kazushi Onoda, Minori Hyodo, Tomoko Inoue, Tatsuo Ishii, Kazunari Kudo, Masatoshi |
description | Purpose
To compare four imaging approaches in cirrhotic estimation; pre‐enhancement T1 relaxation time (T1RT), reduction rate (RR) of T1RT, signal‐based liver‐to‐muscle ratio (L/M ratio) on gadolinium ethoxybenzyl diethylenetriaminepentaacetic acid (Gd‐EOB‐DTPA)‐enhanced magnetic resonance imaging (MRI), and liver stiffness measurement (LSM) of US elastography.
Materials and Methods
Consecutive 58 patients with chronic liver diseases who underwent both Gd‐EOB‐DTPA‐enhanced MRI and FibroScan were analyzed. Four imaging approaches were evaluated by fibrosis score from liver biopsy and receiver operating characteristic (ROC) analysis.
Results
RR was found to be inversely correlated with LSM (r = −0.65). RR decreased with degree of fibrosis (F0‐F1, 58.5 ± 6.2%, versus F2‐F3‐F4, 48.8 ± 11.7%, P = 0.010, F0‐F1‐F2, 58.2 ± 6.2% versus F3‐F4, 45.5 ± 12.3%, P = 0.010 and F0‐F1, 58.5 ± 6.2%, versus F2‐F3, 52.1 ± 12.0%, P = 0.0038). LSM increased with degree of fibrosis (F0‐F1, 5.4 ± 2.2 kPa versus F2‐F3‐F3, 19.3 ± 15.5 kPa, P = 0.0011 and F0‐F1‐F2, 6.8 ± 3.6 kPa versus F3‐F4, 23.8 ± 17.1 kPa, P = 0.0029 and F0‐F1, 5.4 ± 2.2 kPa, versus F2‐F3, 11.4 ± 7.2 kPa, P = 0.0098). Area under ROC curves were 0.83 (F3‐F4), 0.72 (F2‐F3‐F4), 0.68 (F2‐F3) for RR and 0.83 (F3‐F4), 0.88 (F2‐F3‐F4), 0.81 (F2‐F3) for LSM in discriminating between patients with fibrosis.
Conclusion
The capability by LSM was better than those by RR of T1RT, pre‐enhancement T1RT, and L/M ratio to differentiate F ≥ 2, but LSM and RR of T1RT showed the same value to differentiate F ≥ 3. J. Magn. Reson. Imaging 2015;41:329–338.© 2013 Wiley Periodicals, Inc. |
doi_str_mv | 10.1002/jmri.24529 |
format | Article |
fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1660429707</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1652455742</sourcerecordid><originalsourceid>FETCH-LOGICAL-c6009-c84fbf932aeed44f681e1367f1851a2702c6556f0d1c77c10253f3e2aff4fb963</originalsourceid><addsrcrecordid>eNqNkc1u1DAURiNERUvLhgdAltggpBT_O1m2Q5m2GlrEDLC0PMk14yGJBztpO4_Dm-IhbRcsECtfWec7V1dflr0k-JhgTN-t2-COKRe0fJIdEEFpTkUhn6YZC5aTAqv97HmMa4xxWXLxLNunnHFWcHyQ_Zr4dmOCi75DS-hvATq0IChAY-5M79Jv71pA3qJpnZ9dn-bvF59OcuhWpqugRh8_XyDT1ahxNxBQ7J21HcSIWjBxCNBC1--yQ9MHE_2QyCSOvf8ezGa1RS7pV4DgxjTDuC3BlQth5XtXjdajbM-aJsKL-_cw-_LhbDE5z2fX04vJySyvZLorrwpul7Zk1ADUnFtZECBMKksKQQxVmFZSCGlxTSqlKoKpYJYBNdamYCnZYfZm9G6C_zlA7HXrYgVNYzrwQ9RESsxpqbD6D1SkOoTiNKGv_0LXfghdOiRRXNGykJgl6u1IVcHHGMDqTXCtCVtNsN51rHcd6z8dJ_jVvXJYtlA_og-lJoCMwK1rYPsPlb5M_T1I8zHjYg93jxkTfmipmBL629VUz_lsOp98Pddz9htsvsHF</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1647298603</pqid></control><display><type>article</type><title>Comparison between T1 relaxation time of Gd-EOB-DTPA-enhanced MRI and liver stiffness measurement of ultrasound elastography in the evaluation of cirrhotic liver</title><source>MEDLINE</source><source>Wiley Journals</source><source>Wiley Free Content</source><creator>Okada, Masahiro ; Murakami, Takamichi ; Yada, Norihisa ; Numata, Kazushi ; Onoda, Minori ; Hyodo, Tomoko ; Inoue, Tatsuo ; Ishii, Kazunari ; Kudo, Masatoshi</creator><creatorcontrib>Okada, Masahiro ; Murakami, Takamichi ; Yada, Norihisa ; Numata, Kazushi ; Onoda, Minori ; Hyodo, Tomoko ; Inoue, Tatsuo ; Ishii, Kazunari ; Kudo, Masatoshi</creatorcontrib><description>Purpose
To compare four imaging approaches in cirrhotic estimation; pre‐enhancement T1 relaxation time (T1RT), reduction rate (RR) of T1RT, signal‐based liver‐to‐muscle ratio (L/M ratio) on gadolinium ethoxybenzyl diethylenetriaminepentaacetic acid (Gd‐EOB‐DTPA)‐enhanced magnetic resonance imaging (MRI), and liver stiffness measurement (LSM) of US elastography.
Materials and Methods
Consecutive 58 patients with chronic liver diseases who underwent both Gd‐EOB‐DTPA‐enhanced MRI and FibroScan were analyzed. Four imaging approaches were evaluated by fibrosis score from liver biopsy and receiver operating characteristic (ROC) analysis.
Results
RR was found to be inversely correlated with LSM (r = −0.65). RR decreased with degree of fibrosis (F0‐F1, 58.5 ± 6.2%, versus F2‐F3‐F4, 48.8 ± 11.7%, P = 0.010, F0‐F1‐F2, 58.2 ± 6.2% versus F3‐F4, 45.5 ± 12.3%, P = 0.010 and F0‐F1, 58.5 ± 6.2%, versus F2‐F3, 52.1 ± 12.0%, P = 0.0038). LSM increased with degree of fibrosis (F0‐F1, 5.4 ± 2.2 kPa versus F2‐F3‐F3, 19.3 ± 15.5 kPa, P = 0.0011 and F0‐F1‐F2, 6.8 ± 3.6 kPa versus F3‐F4, 23.8 ± 17.1 kPa, P = 0.0029 and F0‐F1, 5.4 ± 2.2 kPa, versus F2‐F3, 11.4 ± 7.2 kPa, P = 0.0098). Area under ROC curves were 0.83 (F3‐F4), 0.72 (F2‐F3‐F4), 0.68 (F2‐F3) for RR and 0.83 (F3‐F4), 0.88 (F2‐F3‐F4), 0.81 (F2‐F3) for LSM in discriminating between patients with fibrosis.
Conclusion
The capability by LSM was better than those by RR of T1RT, pre‐enhancement T1RT, and L/M ratio to differentiate F ≥ 2, but LSM and RR of T1RT showed the same value to differentiate F ≥ 3. J. Magn. Reson. Imaging 2015;41:329–338.© 2013 Wiley Periodicals, Inc.</description><identifier>ISSN: 1053-1807</identifier><identifier>EISSN: 1522-2586</identifier><identifier>DOI: 10.1002/jmri.24529</identifier><identifier>PMID: 24343840</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Biopsy ; Chronic Disease ; Contrast Media ; Elasticity Imaging Techniques - methods ; elastography ; Female ; Gadolinium DTPA ; Gd-EOB-DTPA ; Humans ; Liver ; Liver Cirrhosis - diagnosis ; Liver Cirrhosis - diagnostic imaging ; liver fibrosis ; Magnetic resonance imaging ; Magnetic Resonance Imaging - methods ; Male ; Medical research ; Middle Aged ; MRI ; NMR ; Nuclear magnetic resonance ; T1 relaxation time</subject><ispartof>Journal of magnetic resonance imaging, 2015-02, Vol.41 (2), p.329-338</ispartof><rights>2013 Wiley Periodicals, Inc.</rights><rights>2015 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c6009-c84fbf932aeed44f681e1367f1851a2702c6556f0d1c77c10253f3e2aff4fb963</citedby><cites>FETCH-LOGICAL-c6009-c84fbf932aeed44f681e1367f1851a2702c6556f0d1c77c10253f3e2aff4fb963</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjmri.24529$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjmri.24529$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,1433,27924,27925,45574,45575,46409,46833</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24343840$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Okada, Masahiro</creatorcontrib><creatorcontrib>Murakami, Takamichi</creatorcontrib><creatorcontrib>Yada, Norihisa</creatorcontrib><creatorcontrib>Numata, Kazushi</creatorcontrib><creatorcontrib>Onoda, Minori</creatorcontrib><creatorcontrib>Hyodo, Tomoko</creatorcontrib><creatorcontrib>Inoue, Tatsuo</creatorcontrib><creatorcontrib>Ishii, Kazunari</creatorcontrib><creatorcontrib>Kudo, Masatoshi</creatorcontrib><title>Comparison between T1 relaxation time of Gd-EOB-DTPA-enhanced MRI and liver stiffness measurement of ultrasound elastography in the evaluation of cirrhotic liver</title><title>Journal of magnetic resonance imaging</title><addtitle>J. Magn. Reson. Imaging</addtitle><description>Purpose
To compare four imaging approaches in cirrhotic estimation; pre‐enhancement T1 relaxation time (T1RT), reduction rate (RR) of T1RT, signal‐based liver‐to‐muscle ratio (L/M ratio) on gadolinium ethoxybenzyl diethylenetriaminepentaacetic acid (Gd‐EOB‐DTPA)‐enhanced magnetic resonance imaging (MRI), and liver stiffness measurement (LSM) of US elastography.
Materials and Methods
Consecutive 58 patients with chronic liver diseases who underwent both Gd‐EOB‐DTPA‐enhanced MRI and FibroScan were analyzed. Four imaging approaches were evaluated by fibrosis score from liver biopsy and receiver operating characteristic (ROC) analysis.
Results
RR was found to be inversely correlated with LSM (r = −0.65). RR decreased with degree of fibrosis (F0‐F1, 58.5 ± 6.2%, versus F2‐F3‐F4, 48.8 ± 11.7%, P = 0.010, F0‐F1‐F2, 58.2 ± 6.2% versus F3‐F4, 45.5 ± 12.3%, P = 0.010 and F0‐F1, 58.5 ± 6.2%, versus F2‐F3, 52.1 ± 12.0%, P = 0.0038). LSM increased with degree of fibrosis (F0‐F1, 5.4 ± 2.2 kPa versus F2‐F3‐F3, 19.3 ± 15.5 kPa, P = 0.0011 and F0‐F1‐F2, 6.8 ± 3.6 kPa versus F3‐F4, 23.8 ± 17.1 kPa, P = 0.0029 and F0‐F1, 5.4 ± 2.2 kPa, versus F2‐F3, 11.4 ± 7.2 kPa, P = 0.0098). Area under ROC curves were 0.83 (F3‐F4), 0.72 (F2‐F3‐F4), 0.68 (F2‐F3) for RR and 0.83 (F3‐F4), 0.88 (F2‐F3‐F4), 0.81 (F2‐F3) for LSM in discriminating between patients with fibrosis.
Conclusion
The capability by LSM was better than those by RR of T1RT, pre‐enhancement T1RT, and L/M ratio to differentiate F ≥ 2, but LSM and RR of T1RT showed the same value to differentiate F ≥ 3. J. Magn. Reson. Imaging 2015;41:329–338.© 2013 Wiley Periodicals, Inc.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biopsy</subject><subject>Chronic Disease</subject><subject>Contrast Media</subject><subject>Elasticity Imaging Techniques - methods</subject><subject>elastography</subject><subject>Female</subject><subject>Gadolinium DTPA</subject><subject>Gd-EOB-DTPA</subject><subject>Humans</subject><subject>Liver</subject><subject>Liver Cirrhosis - diagnosis</subject><subject>Liver Cirrhosis - diagnostic imaging</subject><subject>liver fibrosis</subject><subject>Magnetic resonance imaging</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Male</subject><subject>Medical research</subject><subject>Middle Aged</subject><subject>MRI</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>T1 relaxation time</subject><issn>1053-1807</issn><issn>1522-2586</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkc1u1DAURiNERUvLhgdAltggpBT_O1m2Q5m2GlrEDLC0PMk14yGJBztpO4_Dm-IhbRcsECtfWec7V1dflr0k-JhgTN-t2-COKRe0fJIdEEFpTkUhn6YZC5aTAqv97HmMa4xxWXLxLNunnHFWcHyQ_Zr4dmOCi75DS-hvATq0IChAY-5M79Jv71pA3qJpnZ9dn-bvF59OcuhWpqugRh8_XyDT1ahxNxBQ7J21HcSIWjBxCNBC1--yQ9MHE_2QyCSOvf8ezGa1RS7pV4DgxjTDuC3BlQth5XtXjdajbM-aJsKL-_cw-_LhbDE5z2fX04vJySyvZLorrwpul7Zk1ADUnFtZECBMKksKQQxVmFZSCGlxTSqlKoKpYJYBNdamYCnZYfZm9G6C_zlA7HXrYgVNYzrwQ9RESsxpqbD6D1SkOoTiNKGv_0LXfghdOiRRXNGykJgl6u1IVcHHGMDqTXCtCVtNsN51rHcd6z8dJ_jVvXJYtlA_og-lJoCMwK1rYPsPlb5M_T1I8zHjYg93jxkTfmipmBL629VUz_lsOp98Pddz9htsvsHF</recordid><startdate>201502</startdate><enddate>201502</enddate><creator>Okada, Masahiro</creator><creator>Murakami, Takamichi</creator><creator>Yada, Norihisa</creator><creator>Numata, Kazushi</creator><creator>Onoda, Minori</creator><creator>Hyodo, Tomoko</creator><creator>Inoue, Tatsuo</creator><creator>Ishii, Kazunari</creator><creator>Kudo, Masatoshi</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>201502</creationdate><title>Comparison between T1 relaxation time of Gd-EOB-DTPA-enhanced MRI and liver stiffness measurement of ultrasound elastography in the evaluation of cirrhotic liver</title><author>Okada, Masahiro ; Murakami, Takamichi ; Yada, Norihisa ; Numata, Kazushi ; Onoda, Minori ; Hyodo, Tomoko ; Inoue, Tatsuo ; Ishii, Kazunari ; Kudo, Masatoshi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c6009-c84fbf932aeed44f681e1367f1851a2702c6556f0d1c77c10253f3e2aff4fb963</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biopsy</topic><topic>Chronic Disease</topic><topic>Contrast Media</topic><topic>Elasticity Imaging Techniques - methods</topic><topic>elastography</topic><topic>Female</topic><topic>Gadolinium DTPA</topic><topic>Gd-EOB-DTPA</topic><topic>Humans</topic><topic>Liver</topic><topic>Liver Cirrhosis - diagnosis</topic><topic>Liver Cirrhosis - diagnostic imaging</topic><topic>liver fibrosis</topic><topic>Magnetic resonance imaging</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Male</topic><topic>Medical research</topic><topic>Middle Aged</topic><topic>MRI</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>T1 relaxation time</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Okada, Masahiro</creatorcontrib><creatorcontrib>Murakami, Takamichi</creatorcontrib><creatorcontrib>Yada, Norihisa</creatorcontrib><creatorcontrib>Numata, Kazushi</creatorcontrib><creatorcontrib>Onoda, Minori</creatorcontrib><creatorcontrib>Hyodo, Tomoko</creatorcontrib><creatorcontrib>Inoue, Tatsuo</creatorcontrib><creatorcontrib>Ishii, Kazunari</creatorcontrib><creatorcontrib>Kudo, Masatoshi</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of magnetic resonance imaging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Okada, Masahiro</au><au>Murakami, Takamichi</au><au>Yada, Norihisa</au><au>Numata, Kazushi</au><au>Onoda, Minori</au><au>Hyodo, Tomoko</au><au>Inoue, Tatsuo</au><au>Ishii, Kazunari</au><au>Kudo, Masatoshi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparison between T1 relaxation time of Gd-EOB-DTPA-enhanced MRI and liver stiffness measurement of ultrasound elastography in the evaluation of cirrhotic liver</atitle><jtitle>Journal of magnetic resonance imaging</jtitle><addtitle>J. Magn. Reson. Imaging</addtitle><date>2015-02</date><risdate>2015</risdate><volume>41</volume><issue>2</issue><spage>329</spage><epage>338</epage><pages>329-338</pages><issn>1053-1807</issn><eissn>1522-2586</eissn><abstract>Purpose
To compare four imaging approaches in cirrhotic estimation; pre‐enhancement T1 relaxation time (T1RT), reduction rate (RR) of T1RT, signal‐based liver‐to‐muscle ratio (L/M ratio) on gadolinium ethoxybenzyl diethylenetriaminepentaacetic acid (Gd‐EOB‐DTPA)‐enhanced magnetic resonance imaging (MRI), and liver stiffness measurement (LSM) of US elastography.
Materials and Methods
Consecutive 58 patients with chronic liver diseases who underwent both Gd‐EOB‐DTPA‐enhanced MRI and FibroScan were analyzed. Four imaging approaches were evaluated by fibrosis score from liver biopsy and receiver operating characteristic (ROC) analysis.
Results
RR was found to be inversely correlated with LSM (r = −0.65). RR decreased with degree of fibrosis (F0‐F1, 58.5 ± 6.2%, versus F2‐F3‐F4, 48.8 ± 11.7%, P = 0.010, F0‐F1‐F2, 58.2 ± 6.2% versus F3‐F4, 45.5 ± 12.3%, P = 0.010 and F0‐F1, 58.5 ± 6.2%, versus F2‐F3, 52.1 ± 12.0%, P = 0.0038). LSM increased with degree of fibrosis (F0‐F1, 5.4 ± 2.2 kPa versus F2‐F3‐F3, 19.3 ± 15.5 kPa, P = 0.0011 and F0‐F1‐F2, 6.8 ± 3.6 kPa versus F3‐F4, 23.8 ± 17.1 kPa, P = 0.0029 and F0‐F1, 5.4 ± 2.2 kPa, versus F2‐F3, 11.4 ± 7.2 kPa, P = 0.0098). Area under ROC curves were 0.83 (F3‐F4), 0.72 (F2‐F3‐F4), 0.68 (F2‐F3) for RR and 0.83 (F3‐F4), 0.88 (F2‐F3‐F4), 0.81 (F2‐F3) for LSM in discriminating between patients with fibrosis.
Conclusion
The capability by LSM was better than those by RR of T1RT, pre‐enhancement T1RT, and L/M ratio to differentiate F ≥ 2, but LSM and RR of T1RT showed the same value to differentiate F ≥ 3. J. Magn. Reson. Imaging 2015;41:329–338.© 2013 Wiley Periodicals, Inc.</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>24343840</pmid><doi>10.1002/jmri.24529</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Adult Aged Aged, 80 and over Biopsy Chronic Disease Contrast Media Elasticity Imaging Techniques - methods elastography Female Gadolinium DTPA Gd-EOB-DTPA Humans Liver Liver Cirrhosis - diagnosis Liver Cirrhosis - diagnostic imaging liver fibrosis Magnetic resonance imaging Magnetic Resonance Imaging - methods Male Medical research Middle Aged MRI NMR Nuclear magnetic resonance T1 relaxation time |
title | Comparison between T1 relaxation time of Gd-EOB-DTPA-enhanced MRI and liver stiffness measurement of ultrasound elastography in the evaluation of cirrhotic liver |
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