Comparison between T1 relaxation time of Gd-EOB-DTPA-enhanced MRI and liver stiffness measurement of ultrasound elastography in the evaluation of cirrhotic liver

Purpose To compare four imaging approaches in cirrhotic estimation; pre‐enhancement T1 relaxation time (T1RT), reduction rate (RR) of T1RT, signal‐based liver‐to‐muscle ratio (L/M ratio) on gadolinium ethoxybenzyl diethylenetriaminepentaacetic acid (Gd‐EOB‐DTPA)‐enhanced magnetic resonance imaging (...

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Veröffentlicht in:Journal of magnetic resonance imaging 2015-02, Vol.41 (2), p.329-338
Hauptverfasser: Okada, Masahiro, Murakami, Takamichi, Yada, Norihisa, Numata, Kazushi, Onoda, Minori, Hyodo, Tomoko, Inoue, Tatsuo, Ishii, Kazunari, Kudo, Masatoshi
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container_end_page 338
container_issue 2
container_start_page 329
container_title Journal of magnetic resonance imaging
container_volume 41
creator Okada, Masahiro
Murakami, Takamichi
Yada, Norihisa
Numata, Kazushi
Onoda, Minori
Hyodo, Tomoko
Inoue, Tatsuo
Ishii, Kazunari
Kudo, Masatoshi
description Purpose To compare four imaging approaches in cirrhotic estimation; pre‐enhancement T1 relaxation time (T1RT), reduction rate (RR) of T1RT, signal‐based liver‐to‐muscle ratio (L/M ratio) on gadolinium ethoxybenzyl diethylenetriaminepentaacetic acid (Gd‐EOB‐DTPA)‐enhanced magnetic resonance imaging (MRI), and liver stiffness measurement (LSM) of US elastography. Materials and Methods Consecutive 58 patients with chronic liver diseases who underwent both Gd‐EOB‐DTPA‐enhanced MRI and FibroScan were analyzed. Four imaging approaches were evaluated by fibrosis score from liver biopsy and receiver operating characteristic (ROC) analysis. Results RR was found to be inversely correlated with LSM (r = −0.65). RR decreased with degree of fibrosis (F0‐F1, 58.5 ± 6.2%, versus F2‐F3‐F4, 48.8 ± 11.7%, P = 0.010, F0‐F1‐F2, 58.2 ± 6.2% versus F3‐F4, 45.5 ± 12.3%, P = 0.010 and F0‐F1, 58.5 ± 6.2%, versus F2‐F3, 52.1 ± 12.0%, P = 0.0038). LSM increased with degree of fibrosis (F0‐F1, 5.4 ± 2.2 kPa versus F2‐F3‐F3, 19.3 ± 15.5 kPa, P = 0.0011 and F0‐F1‐F2, 6.8 ± 3.6 kPa versus F3‐F4, 23.8 ± 17.1 kPa, P = 0.0029 and F0‐F1, 5.4 ± 2.2 kPa, versus F2‐F3, 11.4 ± 7.2 kPa, P = 0.0098). Area under ROC curves were 0.83 (F3‐F4), 0.72 (F2‐F3‐F4), 0.68 (F2‐F3) for RR and 0.83 (F3‐F4), 0.88 (F2‐F3‐F4), 0.81 (F2‐F3) for LSM in discriminating between patients with fibrosis. Conclusion The capability by LSM was better than those by RR of T1RT, pre‐enhancement T1RT, and L/M ratio to differentiate F ≥ 2, but LSM and RR of T1RT showed the same value to differentiate F ≥ 3. J. Magn. Reson. Imaging 2015;41:329–338.© 2013 Wiley Periodicals, Inc.
doi_str_mv 10.1002/jmri.24529
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Materials and Methods Consecutive 58 patients with chronic liver diseases who underwent both Gd‐EOB‐DTPA‐enhanced MRI and FibroScan were analyzed. Four imaging approaches were evaluated by fibrosis score from liver biopsy and receiver operating characteristic (ROC) analysis. Results RR was found to be inversely correlated with LSM (r = −0.65). RR decreased with degree of fibrosis (F0‐F1, 58.5 ± 6.2%, versus F2‐F3‐F4, 48.8 ± 11.7%, P = 0.010, F0‐F1‐F2, 58.2 ± 6.2% versus F3‐F4, 45.5 ± 12.3%, P = 0.010 and F0‐F1, 58.5 ± 6.2%, versus F2‐F3, 52.1 ± 12.0%, P = 0.0038). LSM increased with degree of fibrosis (F0‐F1, 5.4 ± 2.2 kPa versus F2‐F3‐F3, 19.3 ± 15.5 kPa, P = 0.0011 and F0‐F1‐F2, 6.8 ± 3.6 kPa versus F3‐F4, 23.8 ± 17.1 kPa, P = 0.0029 and F0‐F1, 5.4 ± 2.2 kPa, versus F2‐F3, 11.4 ± 7.2 kPa, P = 0.0098). Area under ROC curves were 0.83 (F3‐F4), 0.72 (F2‐F3‐F4), 0.68 (F2‐F3) for RR and 0.83 (F3‐F4), 0.88 (F2‐F3‐F4), 0.81 (F2‐F3) for LSM in discriminating between patients with fibrosis. Conclusion The capability by LSM was better than those by RR of T1RT, pre‐enhancement T1RT, and L/M ratio to differentiate F ≥ 2, but LSM and RR of T1RT showed the same value to differentiate F ≥ 3. J. Magn. Reson. Imaging 2015;41:329–338.© 2013 Wiley Periodicals, Inc.</description><identifier>ISSN: 1053-1807</identifier><identifier>EISSN: 1522-2586</identifier><identifier>DOI: 10.1002/jmri.24529</identifier><identifier>PMID: 24343840</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Biopsy ; Chronic Disease ; Contrast Media ; Elasticity Imaging Techniques - methods ; elastography ; Female ; Gadolinium DTPA ; Gd-EOB-DTPA ; Humans ; Liver ; Liver Cirrhosis - diagnosis ; Liver Cirrhosis - diagnostic imaging ; liver fibrosis ; Magnetic resonance imaging ; Magnetic Resonance Imaging - methods ; Male ; Medical research ; Middle Aged ; MRI ; NMR ; Nuclear magnetic resonance ; T1 relaxation time</subject><ispartof>Journal of magnetic resonance imaging, 2015-02, Vol.41 (2), p.329-338</ispartof><rights>2013 Wiley Periodicals, Inc.</rights><rights>2015 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c6009-c84fbf932aeed44f681e1367f1851a2702c6556f0d1c77c10253f3e2aff4fb963</citedby><cites>FETCH-LOGICAL-c6009-c84fbf932aeed44f681e1367f1851a2702c6556f0d1c77c10253f3e2aff4fb963</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjmri.24529$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjmri.24529$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,1433,27924,27925,45574,45575,46409,46833</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24343840$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Okada, Masahiro</creatorcontrib><creatorcontrib>Murakami, Takamichi</creatorcontrib><creatorcontrib>Yada, Norihisa</creatorcontrib><creatorcontrib>Numata, Kazushi</creatorcontrib><creatorcontrib>Onoda, Minori</creatorcontrib><creatorcontrib>Hyodo, Tomoko</creatorcontrib><creatorcontrib>Inoue, Tatsuo</creatorcontrib><creatorcontrib>Ishii, Kazunari</creatorcontrib><creatorcontrib>Kudo, Masatoshi</creatorcontrib><title>Comparison between T1 relaxation time of Gd-EOB-DTPA-enhanced MRI and liver stiffness measurement of ultrasound elastography in the evaluation of cirrhotic liver</title><title>Journal of magnetic resonance imaging</title><addtitle>J. Magn. Reson. Imaging</addtitle><description>Purpose To compare four imaging approaches in cirrhotic estimation; pre‐enhancement T1 relaxation time (T1RT), reduction rate (RR) of T1RT, signal‐based liver‐to‐muscle ratio (L/M ratio) on gadolinium ethoxybenzyl diethylenetriaminepentaacetic acid (Gd‐EOB‐DTPA)‐enhanced magnetic resonance imaging (MRI), and liver stiffness measurement (LSM) of US elastography. Materials and Methods Consecutive 58 patients with chronic liver diseases who underwent both Gd‐EOB‐DTPA‐enhanced MRI and FibroScan were analyzed. Four imaging approaches were evaluated by fibrosis score from liver biopsy and receiver operating characteristic (ROC) analysis. Results RR was found to be inversely correlated with LSM (r = −0.65). RR decreased with degree of fibrosis (F0‐F1, 58.5 ± 6.2%, versus F2‐F3‐F4, 48.8 ± 11.7%, P = 0.010, F0‐F1‐F2, 58.2 ± 6.2% versus F3‐F4, 45.5 ± 12.3%, P = 0.010 and F0‐F1, 58.5 ± 6.2%, versus F2‐F3, 52.1 ± 12.0%, P = 0.0038). LSM increased with degree of fibrosis (F0‐F1, 5.4 ± 2.2 kPa versus F2‐F3‐F3, 19.3 ± 15.5 kPa, P = 0.0011 and F0‐F1‐F2, 6.8 ± 3.6 kPa versus F3‐F4, 23.8 ± 17.1 kPa, P = 0.0029 and F0‐F1, 5.4 ± 2.2 kPa, versus F2‐F3, 11.4 ± 7.2 kPa, P = 0.0098). Area under ROC curves were 0.83 (F3‐F4), 0.72 (F2‐F3‐F4), 0.68 (F2‐F3) for RR and 0.83 (F3‐F4), 0.88 (F2‐F3‐F4), 0.81 (F2‐F3) for LSM in discriminating between patients with fibrosis. Conclusion The capability by LSM was better than those by RR of T1RT, pre‐enhancement T1RT, and L/M ratio to differentiate F ≥ 2, but LSM and RR of T1RT showed the same value to differentiate F ≥ 3. J. Magn. Reson. Imaging 2015;41:329–338.© 2013 Wiley Periodicals, Inc.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biopsy</subject><subject>Chronic Disease</subject><subject>Contrast Media</subject><subject>Elasticity Imaging Techniques - methods</subject><subject>elastography</subject><subject>Female</subject><subject>Gadolinium DTPA</subject><subject>Gd-EOB-DTPA</subject><subject>Humans</subject><subject>Liver</subject><subject>Liver Cirrhosis - diagnosis</subject><subject>Liver Cirrhosis - diagnostic imaging</subject><subject>liver fibrosis</subject><subject>Magnetic resonance imaging</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Male</subject><subject>Medical research</subject><subject>Middle Aged</subject><subject>MRI</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>T1 relaxation time</subject><issn>1053-1807</issn><issn>1522-2586</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkc1u1DAURiNERUvLhgdAltggpBT_O1m2Q5m2GlrEDLC0PMk14yGJBztpO4_Dm-IhbRcsECtfWec7V1dflr0k-JhgTN-t2-COKRe0fJIdEEFpTkUhn6YZC5aTAqv97HmMa4xxWXLxLNunnHFWcHyQ_Zr4dmOCi75DS-hvATq0IChAY-5M79Jv71pA3qJpnZ9dn-bvF59OcuhWpqugRh8_XyDT1ahxNxBQ7J21HcSIWjBxCNBC1--yQ9MHE_2QyCSOvf8ezGa1RS7pV4DgxjTDuC3BlQth5XtXjdajbM-aJsKL-_cw-_LhbDE5z2fX04vJySyvZLorrwpul7Zk1ADUnFtZECBMKksKQQxVmFZSCGlxTSqlKoKpYJYBNdamYCnZYfZm9G6C_zlA7HXrYgVNYzrwQ9RESsxpqbD6D1SkOoTiNKGv_0LXfghdOiRRXNGykJgl6u1IVcHHGMDqTXCtCVtNsN51rHcd6z8dJ_jVvXJYtlA_og-lJoCMwK1rYPsPlb5M_T1I8zHjYg93jxkTfmipmBL629VUz_lsOp98Pddz9htsvsHF</recordid><startdate>201502</startdate><enddate>201502</enddate><creator>Okada, Masahiro</creator><creator>Murakami, Takamichi</creator><creator>Yada, Norihisa</creator><creator>Numata, Kazushi</creator><creator>Onoda, Minori</creator><creator>Hyodo, Tomoko</creator><creator>Inoue, Tatsuo</creator><creator>Ishii, Kazunari</creator><creator>Kudo, Masatoshi</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>201502</creationdate><title>Comparison between T1 relaxation time of Gd-EOB-DTPA-enhanced MRI and liver stiffness measurement of ultrasound elastography in the evaluation of cirrhotic liver</title><author>Okada, Masahiro ; Murakami, Takamichi ; Yada, Norihisa ; Numata, Kazushi ; Onoda, Minori ; Hyodo, Tomoko ; Inoue, Tatsuo ; Ishii, Kazunari ; Kudo, Masatoshi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c6009-c84fbf932aeed44f681e1367f1851a2702c6556f0d1c77c10253f3e2aff4fb963</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biopsy</topic><topic>Chronic Disease</topic><topic>Contrast Media</topic><topic>Elasticity Imaging Techniques - methods</topic><topic>elastography</topic><topic>Female</topic><topic>Gadolinium DTPA</topic><topic>Gd-EOB-DTPA</topic><topic>Humans</topic><topic>Liver</topic><topic>Liver Cirrhosis - diagnosis</topic><topic>Liver Cirrhosis - diagnostic imaging</topic><topic>liver fibrosis</topic><topic>Magnetic resonance imaging</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Male</topic><topic>Medical research</topic><topic>Middle Aged</topic><topic>MRI</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>T1 relaxation time</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Okada, Masahiro</creatorcontrib><creatorcontrib>Murakami, Takamichi</creatorcontrib><creatorcontrib>Yada, Norihisa</creatorcontrib><creatorcontrib>Numata, Kazushi</creatorcontrib><creatorcontrib>Onoda, Minori</creatorcontrib><creatorcontrib>Hyodo, Tomoko</creatorcontrib><creatorcontrib>Inoue, Tatsuo</creatorcontrib><creatorcontrib>Ishii, Kazunari</creatorcontrib><creatorcontrib>Kudo, Masatoshi</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of magnetic resonance imaging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Okada, Masahiro</au><au>Murakami, Takamichi</au><au>Yada, Norihisa</au><au>Numata, Kazushi</au><au>Onoda, Minori</au><au>Hyodo, Tomoko</au><au>Inoue, Tatsuo</au><au>Ishii, Kazunari</au><au>Kudo, Masatoshi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparison between T1 relaxation time of Gd-EOB-DTPA-enhanced MRI and liver stiffness measurement of ultrasound elastography in the evaluation of cirrhotic liver</atitle><jtitle>Journal of magnetic resonance imaging</jtitle><addtitle>J. Magn. Reson. Imaging</addtitle><date>2015-02</date><risdate>2015</risdate><volume>41</volume><issue>2</issue><spage>329</spage><epage>338</epage><pages>329-338</pages><issn>1053-1807</issn><eissn>1522-2586</eissn><abstract>Purpose To compare four imaging approaches in cirrhotic estimation; pre‐enhancement T1 relaxation time (T1RT), reduction rate (RR) of T1RT, signal‐based liver‐to‐muscle ratio (L/M ratio) on gadolinium ethoxybenzyl diethylenetriaminepentaacetic acid (Gd‐EOB‐DTPA)‐enhanced magnetic resonance imaging (MRI), and liver stiffness measurement (LSM) of US elastography. Materials and Methods Consecutive 58 patients with chronic liver diseases who underwent both Gd‐EOB‐DTPA‐enhanced MRI and FibroScan were analyzed. Four imaging approaches were evaluated by fibrosis score from liver biopsy and receiver operating characteristic (ROC) analysis. Results RR was found to be inversely correlated with LSM (r = −0.65). RR decreased with degree of fibrosis (F0‐F1, 58.5 ± 6.2%, versus F2‐F3‐F4, 48.8 ± 11.7%, P = 0.010, F0‐F1‐F2, 58.2 ± 6.2% versus F3‐F4, 45.5 ± 12.3%, P = 0.010 and F0‐F1, 58.5 ± 6.2%, versus F2‐F3, 52.1 ± 12.0%, P = 0.0038). LSM increased with degree of fibrosis (F0‐F1, 5.4 ± 2.2 kPa versus F2‐F3‐F3, 19.3 ± 15.5 kPa, P = 0.0011 and F0‐F1‐F2, 6.8 ± 3.6 kPa versus F3‐F4, 23.8 ± 17.1 kPa, P = 0.0029 and F0‐F1, 5.4 ± 2.2 kPa, versus F2‐F3, 11.4 ± 7.2 kPa, P = 0.0098). Area under ROC curves were 0.83 (F3‐F4), 0.72 (F2‐F3‐F4), 0.68 (F2‐F3) for RR and 0.83 (F3‐F4), 0.88 (F2‐F3‐F4), 0.81 (F2‐F3) for LSM in discriminating between patients with fibrosis. Conclusion The capability by LSM was better than those by RR of T1RT, pre‐enhancement T1RT, and L/M ratio to differentiate F ≥ 2, but LSM and RR of T1RT showed the same value to differentiate F ≥ 3. J. Magn. Reson. Imaging 2015;41:329–338.© 2013 Wiley Periodicals, Inc.</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>24343840</pmid><doi>10.1002/jmri.24529</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record>
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subjects Adult
Aged
Aged, 80 and over
Biopsy
Chronic Disease
Contrast Media
Elasticity Imaging Techniques - methods
elastography
Female
Gadolinium DTPA
Gd-EOB-DTPA
Humans
Liver
Liver Cirrhosis - diagnosis
Liver Cirrhosis - diagnostic imaging
liver fibrosis
Magnetic resonance imaging
Magnetic Resonance Imaging - methods
Male
Medical research
Middle Aged
MRI
NMR
Nuclear magnetic resonance
T1 relaxation time
title Comparison between T1 relaxation time of Gd-EOB-DTPA-enhanced MRI and liver stiffness measurement of ultrasound elastography in the evaluation of cirrhotic liver
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