Opening of an alternative ion permeation pathway in a nociceptor TRP channel

Besides the canonical pore that allows passage of cations into the cell, the TRPM3 channel has an alternative ‘omega’ permeation pathway formed by the S1–S4 region of the protein. This peripheral pore is inwardly rectifying, whereas the canonical central axis pore is outwardly rectifying. Sensory ne...

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Veröffentlicht in:	Nature chemical biology 2014-03, Vol.10 (3), p.188-195
Hauptverfasser:	Vriens, Joris, Held, Katharina, Janssens, Annelies, Tóth, Balázs István, Kerselaers, Sara, Nilius, Bernd, Vennekens, Rudi, Voets, Thomas
Format:	Artikel
Sprache:	eng
Schlagworte:	14/34 49/109 631/378/340 631/57 631/92/269 64/110 64/60 9/74 9/97 Animals Antifungal Agents - pharmacology Biochemical Engineering Biochemistry Bioorganic Chemistry Cell Biology Chemistry Chemistry/Food Science Clotrimazole - pharmacology HEK293 Cells Humans Ions Ions - metabolism Mice Neurons Neurotransmitter Agents - pharmacology Nociceptors - drug effects Nociceptors - metabolism Pain Pharmacology Sensory perception Signal Transduction - drug effects Transient Receptor Potential Channels - drug effects Transient Receptor Potential Channels - metabolism TRPM Cation Channels - drug effects TRPM Cation Channels - metabolism
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