Ischemic Preconditioning Provides Neuroprotection by Induction of AMP-Activated Protein Kinase-Dependent Autophagy in a Rat Model of Ischemic Stroke

Accumulating evidence suggests that ischemic preconditioning (IPC) increases cerebral tolerance to the subsequent ischemic exposure. However, the underlying mechanisms are still not fully understood. In the present study, we tested the hypothesis that AMP-activated protein kinase (AMPK)-dependent au...

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Veröffentlicht in:	Molecular neurobiology 2015-02, Vol.51 (1), p.220-229
Hauptverfasser:	Jiang, Teng, Yu, Jin-Tai, Zhu, Xi-Chen, Zhang, Qiao-Quan, Tan, Meng-Shan, Cao, Lei, Wang, Hui-Fu, Shi, Jian-Quan, Gao, Li, Qin, Hao, Zhang, Ying-Dong, Tan, Lan
Format:	Artikel
Sprache:	eng
Schlagworte:	AMP-Activated Protein Kinases - antagonists & inhibitors AMP-Activated Protein Kinases - metabolism Animals Apoptosis - drug effects Autophagy Autophagy - drug effects Biomedical and Life Sciences Biomedicine Brain Ischemia - complications Brain Ischemia - enzymology Brain Ischemia - pathology Cell Biology Cerebral Cortex - drug effects Cerebral Cortex - enzymology Cerebral Cortex - pathology Cerebral Cortex - ultrastructure Cerebral Infarction - complications Cerebral Infarction - pathology Disease Models, Animal Enzyme Activation - drug effects Infarction, Middle Cerebral Artery - complications Infarction, Middle Cerebral Artery - enzymology Infarction, Middle Cerebral Artery - pathology Ischemia Ischemic Preconditioning Kinases Male Models, Biological Neurobiology Neurology Neuroprotective Agents - pharmacology Neurosciences Protein Kinase Inhibitors - pharmacology Rats, Sprague-Dawley Stroke Stroke - complications Stroke - enzymology Stroke - pathology
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