A Set of Shear Wave Elastography Quantitative Parameters Combined with Ultrasound BI-RADS to Assess Benign and Malignant Breast Lesions

Abstract The goal of this study was to determine whether a combination of shear wave elastography (SWE) quantitative parameters could improve the accuracy of ultrasonography in the differentiation of benign and malignant breast lesions. Two hundred seventy-nine breast lesions in 251 women were evalu...

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Veröffentlicht in:Ultrasound in medicine & biology 2015-04, Vol.41 (4), p.960-966
Hauptverfasser: Shi, Xian Quan, Li, Jun Lai, Wan, Wen Bo, Huang, Yan
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Li, Jun Lai
Wan, Wen Bo
Huang, Yan
description Abstract The goal of this study was to determine whether a combination of shear wave elastography (SWE) quantitative parameters could improve the accuracy of ultrasonography in the differentiation of benign and malignant breast lesions. Two hundred seventy-nine breast lesions in 251 women were evaluated with ultrasonography and SWE; pathologic results of all lesions were available. Each lesion was classified according to the Breast Imaging Reporting and Data System (BI-RADS) for ultrasound. SWE quantitative parameters, including maximum elastic value ( Emax ), mean elastic value ( Emean ), standard deviation (SD) and ratio of Emean of the lesion to Emean of the surrounding parenchyma ( Eratio ), were recorded. A receiver operating characteristic curve was used to determine their cutoff values. When any of the four parameters was equal to or higher than the cutoff value, the set of SWE parameters was counted as positive. When both BI-RADS and the set were positive, lesions were evaluated as positive for malignancy. We compared the performance of this combination with use of BI-RADS, Emax , Emean , SD or Eratio alone and also with the combination of BI-RADS and Emax for benign/malignant differentiation. The combination of Emax , Emean , SD, or Eratio with BI-RADS had a sensitivity, specificity, positive predictive value, negative predictive value, accuracy and Youden index of 0.967, 0.912, 0.908, 0.969, 0.938 and 0.879, respectively. The accuracy was the highest ( p  
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The combination of Emax , Emean , SD, or Eratio with BI-RADS had a sensitivity, specificity, positive predictive value, negative predictive value, accuracy and Youden index of 0.967, 0.912, 0.908, 0.969, 0.938 and 0.879, respectively. The accuracy was the highest ( p  &lt; 0.01) without loss of sensitivity. Combining a set of SWE quantitative parameters ( Emax , Emean , SD and Eratio ) could improve the accuracy of ultrasonography in differentiation of benign from malignant breast lesions, without loss of sensitivity.</description><identifier>ISSN: 0301-5629</identifier><identifier>EISSN: 1879-291X</identifier><identifier>DOI: 10.1016/j.ultrasmedbio.2014.11.014</identifier><identifier>PMID: 25701532</identifier><language>eng</language><publisher>England: Elsevier Inc</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Breast ; Breast Neoplasms - diagnostic imaging ; Diagnosis, Differential ; Elasticity Imaging Techniques - methods ; Female ; Humans ; Middle Aged ; Radiology ; Radiology Information Systems ; Reproducibility of Results ; ROC Curve ; Routine diagnostic tests ; Sensitivity and Specificity ; Shear wave elastography ; Sonoelastography ; Ultrasonography ; Ultrasonography, Mammary - methods ; Young Adult</subject><ispartof>Ultrasound in medicine &amp; biology, 2015-04, Vol.41 (4), p.960-966</ispartof><rights>World Federation for Ultrasound in Medicine &amp; Biology</rights><rights>2015 World Federation for Ultrasound in Medicine &amp; Biology</rights><rights>Copyright © 2015 World Federation for Ultrasound in Medicine &amp; Biology. 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Two hundred seventy-nine breast lesions in 251 women were evaluated with ultrasonography and SWE; pathologic results of all lesions were available. Each lesion was classified according to the Breast Imaging Reporting and Data System (BI-RADS) for ultrasound. SWE quantitative parameters, including maximum elastic value ( Emax ), mean elastic value ( Emean ), standard deviation (SD) and ratio of Emean of the lesion to Emean of the surrounding parenchyma ( Eratio ), were recorded. A receiver operating characteristic curve was used to determine their cutoff values. When any of the four parameters was equal to or higher than the cutoff value, the set of SWE parameters was counted as positive. When both BI-RADS and the set were positive, lesions were evaluated as positive for malignancy. We compared the performance of this combination with use of BI-RADS, Emax , Emean , SD or Eratio alone and also with the combination of BI-RADS and Emax for benign/malignant differentiation. The combination of Emax , Emean , SD, or Eratio with BI-RADS had a sensitivity, specificity, positive predictive value, negative predictive value, accuracy and Youden index of 0.967, 0.912, 0.908, 0.969, 0.938 and 0.879, respectively. The accuracy was the highest ( p  &lt; 0.01) without loss of sensitivity. 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The combination of Emax , Emean , SD, or Eratio with BI-RADS had a sensitivity, specificity, positive predictive value, negative predictive value, accuracy and Youden index of 0.967, 0.912, 0.908, 0.969, 0.938 and 0.879, respectively. The accuracy was the highest ( p  &lt; 0.01) without loss of sensitivity. Combining a set of SWE quantitative parameters ( Emax , Emean , SD and Eratio ) could improve the accuracy of ultrasonography in differentiation of benign from malignant breast lesions, without loss of sensitivity.</abstract><cop>England</cop><pub>Elsevier Inc</pub><pmid>25701532</pmid><doi>10.1016/j.ultrasmedbio.2014.11.014</doi><tpages>7</tpages></addata></record>
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subjects Adult
Aged
Aged, 80 and over
Breast
Breast Neoplasms - diagnostic imaging
Diagnosis, Differential
Elasticity Imaging Techniques - methods
Female
Humans
Middle Aged
Radiology
Radiology Information Systems
Reproducibility of Results
ROC Curve
Routine diagnostic tests
Sensitivity and Specificity
Shear wave elastography
Sonoelastography
Ultrasonography
Ultrasonography, Mammary - methods
Young Adult
title A Set of Shear Wave Elastography Quantitative Parameters Combined with Ultrasound BI-RADS to Assess Benign and Malignant Breast Lesions
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