Epigenetic modifications of gene promoter DNA in the liver of adult female mice masculinized by testosterone

•Epigenetic reprogramming by testosterone (T) of promoter gene DNA in the liver of female mice.•T induces long-lasting hyper- and hypo-methylations of DNA of 47 and 35 gene promoters.•T does not modify promoter DNA of T-responsive male- and female-predominant genes. Testosterone (T) is known to masc...

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Veröffentlicht in:	The Journal of steroid biochemistry and molecular biology 2015-01, Vol.145, p.121-130
Hauptverfasser:	Dkhil, Mohamed A., Al-Quraishy, Saleh, Abdel-Baki, Abdel-Azeem, Ghanjati, Foued, Arauzo-Bravo, Marcos J., Delic, Denis, Wunderlich, Frank
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals CpG Islands DNA Methylation - drug effects DNA methylomics Epigenesis, Genetic - drug effects Epigenetics Female Gene promoter Immunoprecipitation Liver Liver - metabolism Male Mice Mice, Inbred C57BL Oligonucleotide Array Sequence Analysis Phenotype Promoter Regions, Genetic Testosterone Testosterone - pharmacology
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