Development of high yield reassortants for influenza type B viruses and analysis of their gene compositions
Highlights • High yield (hy) reassortant influenza B seed viruses for vaccine production can be developed through classical reassortment of wild type (wt) B isolates with B/Lee/40 as the hy donor virus. • A detailed method of generating hy influenza B reassortants is presented. • On average hy reass...
Gespeichert in:
| Veröffentlicht in: | Vaccine 2015-02, Vol.33 (7), p.879-884 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 884 |
|---|---|
| container_issue | 7 |
| container_start_page | 879 |
| container_title | Vaccine |
| container_volume | 33 |
| creator | Le, Jianhua Orff, Edward J Fulvini, Andrew A Huang, Liling Onodera, Shiroh Pokorny, Barbara A Malewicz, Andrew Primakov, Patricia Bucher, Doris J |
| description | Highlights • High yield (hy) reassortant influenza B seed viruses for vaccine production can be developed through classical reassortment of wild type (wt) B isolates with B/Lee/40 as the hy donor virus. • A detailed method of generating hy influenza B reassortants is presented. • On average hy reassortants increased the HA titers over their wt counterparts by 8 fold. • NP and PB1 of the B/Lee/40 were important for Victoria lineage reassortants while NP, PB1 and PB2 from B/Lee/40 along with NS from wt were important contributors for hy growth of the Yamagata lineage reassortants. |
| doi_str_mv | 10.1016/j.vaccine.2014.12.027 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1660412509</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0264410X14016703</els_id><sourcerecordid>1652413988</sourcerecordid><originalsourceid>FETCH-LOGICAL-c598t-e8e30721f8c14c364529a09a83912320846e61a1eec3a9da36708e815cf60b8d3</originalsourceid><addsrcrecordid>eNqNkk2L1TAUhoMoznX0JygBN25ac_LRphtFx08YcKGCu5BJT-fmTpvcSdoL9dfbcq8Ks9FFyOZ5n3DyHkKeAiuBQfVyVx6scz5gyRnIEnjJeH2PbEDXouAK9H2yYbyShQT244w8ynnHGFMCmofkjCsllWrUhty8wwP2cT9gGGns6NZfb-nssW9pQptzTKMNY6ZdTNSHrp8w_LR0nPdI39KDT1PGTG1ol2P7Ofu8SsYt-kSvMSB1cdjH7EcfQ35MHnS2z_jkdJ-T7x_ef7v4VFx--fj54s1l4VSjxwI1ClZz6LQD6UQlFW8sa6wWDXDBmZYVVmAB0QnbtFZUNdOoQbmuYle6FefkxdG7T_F2wjyawWeHfW8DxikbqComgSvW_AequATRaL2gz--guzilZeqVklrUtYZVqI6USzHnhJ3ZJz_YNBtgZi3O7MypOLMWZ4Cbpbgl9-xkn64GbP-kfje1AK-PAC4_d_CYTHYeg8PWJ3SjaaP_5xOv7hhc74N3tr_BGfPfaUxeAubruj3r8oBcnDUT4hdv5MCa</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1648377819</pqid></control><display><type>article</type><title>Development of high yield reassortants for influenza type B viruses and analysis of their gene compositions</title><source>MEDLINE</source><source>ScienceDirect Journals (5 years ago - present)</source><source>ProQuest Central UK/Ireland</source><creator>Le, Jianhua ; Orff, Edward J ; Fulvini, Andrew A ; Huang, Liling ; Onodera, Shiroh ; Pokorny, Barbara A ; Malewicz, Andrew ; Primakov, Patricia ; Bucher, Doris J</creator><creatorcontrib>Le, Jianhua ; Orff, Edward J ; Fulvini, Andrew A ; Huang, Liling ; Onodera, Shiroh ; Pokorny, Barbara A ; Malewicz, Andrew ; Primakov, Patricia ; Bucher, Doris J</creatorcontrib><description>Highlights • High yield (hy) reassortant influenza B seed viruses for vaccine production can be developed through classical reassortment of wild type (wt) B isolates with B/Lee/40 as the hy donor virus. • A detailed method of generating hy influenza B reassortants is presented. • On average hy reassortants increased the HA titers over their wt counterparts by 8 fold. • NP and PB1 of the B/Lee/40 were important for Victoria lineage reassortants while NP, PB1 and PB2 from B/Lee/40 along with NS from wt were important contributors for hy growth of the Yamagata lineage reassortants.</description><identifier>ISSN: 0264-410X</identifier><identifier>EISSN: 1873-2518</identifier><identifier>DOI: 10.1016/j.vaccine.2014.12.027</identifier><identifier>PMID: 25545595</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>Allergy and Immunology ; Classical reassortment ; Enzymes ; FDA approval ; Genes ; High yield reassortants ; Humans ; Influenza ; Influenza B gene composition ; Influenza B virus - genetics ; Influenza B virus - immunology ; Influenza vaccine ; Influenza Vaccines - immunology ; Influenza, Human - immunology ; Methods ; Plasmids ; Production capacity ; R&D ; Reassortant Viruses - genetics ; Reassortant Viruses - immunology ; Research & development ; Vaccine seed virus ; Vaccines ; Viral Proteins - immunology ; Viruses</subject><ispartof>Vaccine, 2015-02, Vol.33 (7), p.879-884</ispartof><rights>The Authors</rights><rights>2014 The Authors</rights><rights>Copyright © 2014 The Authors. Published by Elsevier Ltd.. All rights reserved.</rights><rights>Copyright Elsevier Limited Feb 11, 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c598t-e8e30721f8c14c364529a09a83912320846e61a1eec3a9da36708e815cf60b8d3</citedby><cites>FETCH-LOGICAL-c598t-e8e30721f8c14c364529a09a83912320846e61a1eec3a9da36708e815cf60b8d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/1648377819?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995,64385,64387,64389,72341</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25545595$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Le, Jianhua</creatorcontrib><creatorcontrib>Orff, Edward J</creatorcontrib><creatorcontrib>Fulvini, Andrew A</creatorcontrib><creatorcontrib>Huang, Liling</creatorcontrib><creatorcontrib>Onodera, Shiroh</creatorcontrib><creatorcontrib>Pokorny, Barbara A</creatorcontrib><creatorcontrib>Malewicz, Andrew</creatorcontrib><creatorcontrib>Primakov, Patricia</creatorcontrib><creatorcontrib>Bucher, Doris J</creatorcontrib><title>Development of high yield reassortants for influenza type B viruses and analysis of their gene compositions</title><title>Vaccine</title><addtitle>Vaccine</addtitle><description>Highlights • High yield (hy) reassortant influenza B seed viruses for vaccine production can be developed through classical reassortment of wild type (wt) B isolates with B/Lee/40 as the hy donor virus. • A detailed method of generating hy influenza B reassortants is presented. • On average hy reassortants increased the HA titers over their wt counterparts by 8 fold. • NP and PB1 of the B/Lee/40 were important for Victoria lineage reassortants while NP, PB1 and PB2 from B/Lee/40 along with NS from wt were important contributors for hy growth of the Yamagata lineage reassortants.</description><subject>Allergy and Immunology</subject><subject>Classical reassortment</subject><subject>Enzymes</subject><subject>FDA approval</subject><subject>Genes</subject><subject>High yield reassortants</subject><subject>Humans</subject><subject>Influenza</subject><subject>Influenza B gene composition</subject><subject>Influenza B virus - genetics</subject><subject>Influenza B virus - immunology</subject><subject>Influenza vaccine</subject><subject>Influenza Vaccines - immunology</subject><subject>Influenza, Human - immunology</subject><subject>Methods</subject><subject>Plasmids</subject><subject>Production capacity</subject><subject>R&D</subject><subject>Reassortant Viruses - genetics</subject><subject>Reassortant Viruses - immunology</subject><subject>Research & development</subject><subject>Vaccine seed virus</subject><subject>Vaccines</subject><subject>Viral Proteins - immunology</subject><subject>Viruses</subject><issn>0264-410X</issn><issn>1873-2518</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqNkk2L1TAUhoMoznX0JygBN25ac_LRphtFx08YcKGCu5BJT-fmTpvcSdoL9dfbcq8Ks9FFyOZ5n3DyHkKeAiuBQfVyVx6scz5gyRnIEnjJeH2PbEDXouAK9H2yYbyShQT244w8ynnHGFMCmofkjCsllWrUhty8wwP2cT9gGGns6NZfb-nssW9pQptzTKMNY6ZdTNSHrp8w_LR0nPdI39KDT1PGTG1ol2P7Ofu8SsYt-kSvMSB1cdjH7EcfQ35MHnS2z_jkdJ-T7x_ef7v4VFx--fj54s1l4VSjxwI1ClZz6LQD6UQlFW8sa6wWDXDBmZYVVmAB0QnbtFZUNdOoQbmuYle6FefkxdG7T_F2wjyawWeHfW8DxikbqComgSvW_AequATRaL2gz--guzilZeqVklrUtYZVqI6USzHnhJ3ZJz_YNBtgZi3O7MypOLMWZ4Cbpbgl9-xkn64GbP-kfje1AK-PAC4_d_CYTHYeg8PWJ3SjaaP_5xOv7hhc74N3tr_BGfPfaUxeAubruj3r8oBcnDUT4hdv5MCa</recordid><startdate>20150211</startdate><enddate>20150211</enddate><creator>Le, Jianhua</creator><creator>Orff, Edward J</creator><creator>Fulvini, Andrew A</creator><creator>Huang, Liling</creator><creator>Onodera, Shiroh</creator><creator>Pokorny, Barbara A</creator><creator>Malewicz, Andrew</creator><creator>Primakov, Patricia</creator><creator>Bucher, Doris J</creator><general>Elsevier Ltd</general><general>Elsevier Limited</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7RV</scope><scope>7T2</scope><scope>7T5</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88C</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0R</scope><scope>M0S</scope><scope>M0T</scope><scope>M1P</scope><scope>M2O</scope><scope>M7N</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>7U2</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope></search><sort><creationdate>20150211</creationdate><title>Development of high yield reassortants for influenza type B viruses and analysis of their gene compositions</title><author>Le, Jianhua ; Orff, Edward J ; Fulvini, Andrew A ; Huang, Liling ; Onodera, Shiroh ; Pokorny, Barbara A ; Malewicz, Andrew ; Primakov, Patricia ; Bucher, Doris J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c598t-e8e30721f8c14c364529a09a83912320846e61a1eec3a9da36708e815cf60b8d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Allergy and Immunology</topic><topic>Classical reassortment</topic><topic>Enzymes</topic><topic>FDA approval</topic><topic>Genes</topic><topic>High yield reassortants</topic><topic>Humans</topic><topic>Influenza</topic><topic>Influenza B gene composition</topic><topic>Influenza B virus - genetics</topic><topic>Influenza B virus - immunology</topic><topic>Influenza vaccine</topic><topic>Influenza Vaccines - immunology</topic><topic>Influenza, Human - immunology</topic><topic>Methods</topic><topic>Plasmids</topic><topic>Production capacity</topic><topic>R&D</topic><topic>Reassortant Viruses - genetics</topic><topic>Reassortant Viruses - immunology</topic><topic>Research & development</topic><topic>Vaccine seed virus</topic><topic>Vaccines</topic><topic>Viral Proteins - immunology</topic><topic>Viruses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Le, Jianhua</creatorcontrib><creatorcontrib>Orff, Edward J</creatorcontrib><creatorcontrib>Fulvini, Andrew A</creatorcontrib><creatorcontrib>Huang, Liling</creatorcontrib><creatorcontrib>Onodera, Shiroh</creatorcontrib><creatorcontrib>Pokorny, Barbara A</creatorcontrib><creatorcontrib>Malewicz, Andrew</creatorcontrib><creatorcontrib>Primakov, Patricia</creatorcontrib><creatorcontrib>Bucher, Doris J</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Nursing & Allied Health Database</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Healthcare Administration Database (Alumni)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Healthcare Administration Database</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>Safety Science and Risk</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><jtitle>Vaccine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Le, Jianhua</au><au>Orff, Edward J</au><au>Fulvini, Andrew A</au><au>Huang, Liling</au><au>Onodera, Shiroh</au><au>Pokorny, Barbara A</au><au>Malewicz, Andrew</au><au>Primakov, Patricia</au><au>Bucher, Doris J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Development of high yield reassortants for influenza type B viruses and analysis of their gene compositions</atitle><jtitle>Vaccine</jtitle><addtitle>Vaccine</addtitle><date>2015-02-11</date><risdate>2015</risdate><volume>33</volume><issue>7</issue><spage>879</spage><epage>884</epage><pages>879-884</pages><issn>0264-410X</issn><eissn>1873-2518</eissn><abstract>Highlights • High yield (hy) reassortant influenza B seed viruses for vaccine production can be developed through classical reassortment of wild type (wt) B isolates with B/Lee/40 as the hy donor virus. • A detailed method of generating hy influenza B reassortants is presented. • On average hy reassortants increased the HA titers over their wt counterparts by 8 fold. • NP and PB1 of the B/Lee/40 were important for Victoria lineage reassortants while NP, PB1 and PB2 from B/Lee/40 along with NS from wt were important contributors for hy growth of the Yamagata lineage reassortants.</abstract><cop>Netherlands</cop><pub>Elsevier Ltd</pub><pmid>25545595</pmid><doi>10.1016/j.vaccine.2014.12.027</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0264-410X |
| ispartof | Vaccine, 2015-02, Vol.33 (7), p.879-884 |
| issn | 0264-410X 1873-2518 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1660412509 |
| source | MEDLINE; ScienceDirect Journals (5 years ago - present); ProQuest Central UK/Ireland |
| subjects | Allergy and Immunology Classical reassortment Enzymes FDA approval Genes High yield reassortants Humans Influenza Influenza B gene composition Influenza B virus - genetics Influenza B virus - immunology Influenza vaccine Influenza Vaccines - immunology Influenza, Human - immunology Methods Plasmids Production capacity R&D Reassortant Viruses - genetics Reassortant Viruses - immunology Research & development Vaccine seed virus Vaccines Viral Proteins - immunology Viruses |
| title | Development of high yield reassortants for influenza type B viruses and analysis of their gene compositions |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-08T03%3A00%3A27IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Development%20of%20high%20yield%20reassortants%20for%20influenza%20type%20B%20viruses%20and%20analysis%20of%20their%20gene%20compositions&rft.jtitle=Vaccine&rft.au=Le,%20Jianhua&rft.date=2015-02-11&rft.volume=33&rft.issue=7&rft.spage=879&rft.epage=884&rft.pages=879-884&rft.issn=0264-410X&rft.eissn=1873-2518&rft_id=info:doi/10.1016/j.vaccine.2014.12.027&rft_dat=%3Cproquest_cross%3E1652413988%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1648377819&rft_id=info:pmid/25545595&rft_els_id=S0264410X14016703&rfr_iscdi=true |