Development of a protective dermal drug delivery system for therapeutic DNAzymes

[Display omitted] RNA-cleaving DNAzymes are a potential novel class of nucleic acid-based active pharmaceutical ingredients (API). However, developing an appropriate drug delivery system (DDS) that achieves high bioavailability is challenging. Especially in a dermal application, DNAzymes have to ove...

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Veröffentlicht in:	International journal of pharmaceutics 2015-02, Vol.479 (1), p.150-158
Hauptverfasser:	Marquardt, Kay, Eicher, Anna-Carola, Dobler, Dorota, Mäder, Ulf, Schmidts, Thomas, Renz, Harald, Runkel, Frank
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Cutaneous Animals Cell Line Chitosan - chemistry Cytoplasm - metabolism DNA, Catalytic - administration & dosage DNA, Catalytic - chemistry DNA, Catalytic - pharmacology Drug Delivery Systems Enzyme Stability Humans In Vitro Techniques Keratinocytes - drug effects Keratinocytes - metabolism Keratosis, Actinic Liposomes Skin - metabolism Skin Absorption Sus scrofa
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