Comparison of the Gene Transfer Efficiency of mRNA/GL67 and pDNA/GL67 Complexes in Respiratory Cells

Complexes between mRNA and GL67:DOPE:DMPE-PEG5000 (GL67) liposomes were formulated and characterized. Subsequently, the in vitro and in vivo expression characteristics of mRNA/GL67 complexes and pDNA/GL67 complexes, each produced at their optimal ratio, were compared in respiratory cells. Transfecti...

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Veröffentlicht in:	Molecular pharmaceutics 2012-08, Vol.9 (8), p.2136-2145
Hauptverfasser:	Andries, Oliwia, De Filette, Marina, Rejman, Joanna, De Smedt, Stefaan C, Demeester, Jo, Van Poucke, Mario, Peelman, Luc, Peleman, Cindy, Lahoutte, Tony, Sanders, Niek N
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Line Escherichia coli - genetics Escherichia coli - metabolism Gene Transfer Techniques Humans Liposomes - chemistry Mice Mice, Inbred BALB C RNA, Messenger - chemistry RNA, Messenger - genetics Transfection - methods
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