Bicc1 links the regulation of cAMP signaling in polycystic kidneys to microRNA-induced gene silencing

Genetic defects in autosomal-dominant polycystic kidney disease (ADPKD) promote cystic growth of renal tubules, at least in part by stimulating the accumulation of cAMP. How renal cAMP levels are regulated is incompletely understood. We show that cAMP and the expression of its synthetic enzyme adeny...

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Veröffentlicht in:	Journal of molecular cell biology 2012-12, Vol.4 (6), p.398-408
Hauptverfasser:	Piazzon, Nathalie, Maisonneuve, Charlotte, Guilleret, Isabelle, Rotman, Samuel, Constam, Daniel B
Format:	Artikel
Sprache:	eng
Schlagworte:	3' Untranslated Regions - genetics Adenylyl Cyclases - genetics Adenylyl Cyclases - metabolism Animals Argonaute Proteins - genetics Argonaute Proteins - metabolism Carrier Proteins - genetics Carrier Proteins - metabolism Cell Line Cyclic AMP - genetics Cyclic AMP - metabolism Gene Silencing - physiology HEK293 Cells Humans Intracellular Signaling Peptides and Proteins - genetics Intracellular Signaling Peptides and Proteins - metabolism Kidney Tubules - metabolism Kidney Tubules - physiopathology Mice Mice, Inbred C57BL MicroRNAs - genetics MicroRNAs - metabolism Polycystic Kidney Diseases - metabolism Polycystic Kidney Diseases - physiopathology RNA, Messenger - genetics RNA, Messenger - metabolism RNA-Binding Proteins - genetics RNA-Binding Proteins - metabolism Signal Transduction - genetics Signal Transduction - physiology
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