Osteocytes up-regulate the terminal differentiation of pre-osteoblasts via gap junctions

•We examined cell-to-cell interaction between pre-osteoblasts and osteocytes.•ALP and BSP expression in pre-osteoblasts co-cultured with osteocytes was increased.•Gap junctions were detected between pre-osteoblasts and osteocytes.•The gap junction inhibitor suppressed the increased expression of ALP...

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Veröffentlicht in:	Biochemical and biophysical research communications 2015-01, Vol.456 (1), p.1-6
Hauptverfasser:	Nishikawa, Yoichi, Akiyama, Yuko, Yamamoto, Kiyofumi, Kobayashi, Masayuki, Watanabe, Eri, Watanabe, Nobukazu, Shimizu, Noriyoshi, Mikami, Yoshikazu, Komiyama, Kazuo
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3 Cells Alkaline phosphatase Alkaline Phosphatase - metabolism Animals Bone sialoprotein Carbenoxolone - chemistry Carrier Proteins - metabolism Cell Communication Cell Cycle Cell Differentiation Coculture Techniques Gap junction Gap Junctions - physiology Gene Expression Regulation Green Fluorescent Proteins - metabolism Humans Integrin-Binding Sialoprotein - metabolism Mice Osteoblasts Osteoblasts - cytology Osteocytes Osteocytes - cytology Osteocytes - metabolism Patch-Clamp Techniques RNA, Messenger - metabolism
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