Novel Heterobimetallic Radiotheranostic: Preparation, Activity, and Biodistribution

A novel RuII(arene) theranostic complex is presented. It is based on a 1,4,7,10‐tetraazacyclododecane‐1,4,7,10‐tetraacetic acid macrocycle bearing a triarylphosphine and can be tracked in vivo by using the γ emission of 153Sm atoms. Notably, the heteroditopic ligand can be selectively metalated with...

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Veröffentlicht in:	ChemMedChem 2014-07, Vol.9 (7), p.1567-1573
Hauptverfasser:	Adriaenssens, Louis, Liu, Qiang, Chaux-Picquet, Fanny, Tasan, Semra, Picquet, Michel, Denat, Franck, Le Gendre, Pierre, Marques, Fernanda, Fernandes, Célia, Mendes, Filipa, Gano, Lurdes, Campello, Maria Paula Cabral, Bodio, Ewen
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Line, Tumor Cell Survival - drug effects Coordination Complexes - chemical synthesis Coordination Complexes - pharmacokinetics Coordination Complexes - pharmacology Heterocyclic Compounds, 1-Ring - chemistry heterometallic complexes Humans Isotope Labeling macrocycles Mice phosphines Phosphines - chemistry radiopharmaceuticals Radiopharmaceuticals - chemical synthesis Radiopharmaceuticals - pharmacokinetics Radiopharmaceuticals - pharmacology Ruthenium - chemistry theranostics Tissue Distribution Water - chemistry
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