1,2,3,9b-Tetrahydro-5H-imidazo[2,1-a]isoindol-5-ones as a new class of respiratory syncytial virus (RSV) fusion inhibitors. Part 2: Identification of BTA9881 as a preclinical candidate

[Display omitted] Respiratory syncytial virus (RSV) is a major cause of respiratory tract infections in infants, young children and adults. 1,2,3,9b-Tetrahydro-5H-imidazo[2,1-a]isoindol-5-ones with general structure 1 were previously identified as promising inhibitors of RSV targeting the fusion gly...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2015-02, Vol.25 (4), p.976-981
Hauptverfasser:	Bond, Silas, Draffan, Alistair G., Fenner, Jennifer E., Lambert, John, Lim, Chin Yu, Lin, Bo, Luttick, Angela, Mitchell, Jeffrey P., Morton, Craig J., Nearn, Roland H., Sanford, Vanessa, Anderson, Kelly H., Mayes, Penelope A., Tucker, Simon P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antiviral Antiviral Agents - pharmacology Humans Imidazoles - pharmacology Membrane Fusion - drug effects Respiratory syncytial virus Respiratory Syncytial Viruses - drug effects Respiratory Syncytial Viruses - physiology Synthesis
Online-Zugang:	Volltext
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