Inhibition of human alcohol and aldehyde dehydrogenases by acetaminophen: Assessment of the effects on first-pass metabolism of ethanol

Abstract Acetaminophen is one of the most widely used over-the-counter analgesic, antipyretic medications. Use of acetaminophen and alcohol are commonly associated. Previous studies showed that acetaminophen might affect bioavailability of ethanol by inhibiting gastric alcohol dehydrogenase (ADH). H...

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Veröffentlicht in:	Alcohol (Fayetteville, N.Y.) N.Y.), 2013-11, Vol.47 (7), p.559-565
Hauptverfasser:	Lee, Yung-Pin, Liao, Jian-Tong, Cheng, Ya-Wen, Wu, Ting-Lun, Lee, Shou-Lun, Liu, Jong-Kang, Yin, Shih-Jiun
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetaminophen Acetaminophen - pharmacology Alcohol Alcohol dehydrogenase Alcohol Dehydrogenase - antagonists & inhibitors Aldehyde dehydrogenase Aldehyde Dehydrogenase - antagonists & inhibitors Dehydrogenases Enzymes Ethanol Ethanol - metabolism First-pass metabolism of ethanol Humans Inactivation, Metabolic Inhibition kinetics Intestine, Small - enzymology Isoenzymes - metabolism Kinetics Liver - enzymology Metabolic interaction Metabolism Molecular Docking Simulation Proteins Psychiatry Stomach - enzymology
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