Anosognosia in Alzheimer's disease: Diagnosis, frequency, mechanism and clinical correlates
Anosognosia is present in a large proportion of patients with mild Alzheimer's disease (AD), and its frequency increases with the progression of the illness. Several instruments have been validated to assess anosognosia in AD, but there is no consensus regarding the best diagnostic strategy. An...
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| Veröffentlicht in: | Cortex 2014-12, Vol.61, p.64-73 |
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| creator | Starkstein, Sergio E. |
| description | Anosognosia is present in a large proportion of patients with mild Alzheimer's disease (AD), and its frequency increases with the progression of the illness. Several instruments have been validated to assess anosognosia in AD, but there is no consensus regarding the best diagnostic strategy. Anosognosia in AD is a significant predictor of apathy and is significantly related to lower depression and anxiety scores, more severe caregiver burden and dangerous behaviours. Studies using different imaging modalities have demonstrated an association between anosognosia and dysfunction in frontal, temporomedial and temporoparietal regions. The mechanism of anosognosia remains unknown, but it has been explained as a consequence of deficits of encoding and updating biographical memory, and dysfunction of comparator, executive and metacognitive systems. |
| doi_str_mv | 10.1016/j.cortex.2014.07.019 |
| format | Article |
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Several instruments have been validated to assess anosognosia in AD, but there is no consensus regarding the best diagnostic strategy. Anosognosia in AD is a significant predictor of apathy and is significantly related to lower depression and anxiety scores, more severe caregiver burden and dangerous behaviours. Studies using different imaging modalities have demonstrated an association between anosognosia and dysfunction in frontal, temporomedial and temporoparietal regions. 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| subjects | Agnosia - complications Agnosia - diagnosis Alzheimer Disease - complications Alzheimer Disease - diagnosis Alzheimer's disease Anosognosia Apathy - physiology Awareness Depression - diagnosis Diagnosis, Differential Humans Insight Memory - physiology Self-knowledge |
| title | Anosognosia in Alzheimer's disease: Diagnosis, frequency, mechanism and clinical correlates |
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