Clinical significance of vascular endothelial growth factor and vascular endothelial growth factor receptor-2 gene polymorphisms in patients with gastrointestinal stromal tumors
Aim The vascular endothelial growth factor (VEGF) or its family might play role in tumor‐related angiogenesis in gastrointestinal stromal tumors (GIST), thereby affecting the prognosis. Accordingly, the present study analyzed the impact of VEGF and VEGF receptor‐2 (VEGFR‐2) gene polymorphisms on the...
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| Veröffentlicht in: | Asia-Pacific journal of clinical oncology 2014-06, Vol.10 (2), p.e40-e45 |
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| creator | Kang, Byung Woog Kim, Jong Gwang Chae, Yee Soo Bae, Han Ik Kwon, Ohkyoung Chung, Ho Young Yu, Wansik Song, Hong Suk Kang, Yu Na Ryu, Seung Wan Lee, Kyung Hee Bae, Young Kyung Choi, Joon Hyuk Kim, Se Won Ryoo, Hun-Mo Cho, Chang-Ho Chae, Hyun-Dong Park, Kyun Woo Gu, Mi Jin Bae, Byung-Jo |
| description | Aim
The vascular endothelial growth factor (VEGF) or its family might play role in tumor‐related angiogenesis in gastrointestinal stromal tumors (GIST), thereby affecting the prognosis. Accordingly, the present study analyzed the impact of VEGF and VEGF receptor‐2 (VEGFR‐2) gene polymorphisms on the prognosis for GIST patients.
Methods
In all, 213 consecutive patients with GIST from five medical centers were enrolled in the present study. The genomic DNA was extracted from paraffin‐embedded tumor tissue, and four VEGF (−2578C/A, −1498C/T, −634G/C, and +936C/T) and one VEGFR‐2 (+1416A/T) gene polymorphisms were determined using a Sequenom MassARRAY system.
Results
With a median follow up of 18.4 months, the estimated 5‐year relapse‐free survival and overall survival rates were 70 and 87%, respectively. In a multivariate analysis including age, sex, primary site of disease, pathology and risk stratification, no significant association was observed between the polymorphism of the VEGF and VEGFR‐2 genes and survival.
Conclusion
None of the five VEGF and VEGFR‐2 gene polymorphisms investigated in this study was found to be an independent prognostic marker for Korean patients with surgically resected GIST. However, further studies on a larger scale are warranted to clarify the role of VEGF and VEGFR gene polymorphisms as a prognostic biomarker for GIST patients. |
| doi_str_mv | 10.1111/ajco.12068 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1660403668</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1529841727</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4008-95e951638c886b3908aa32633ab84988c6ec81501ee3137c70548be8d7b4b8033</originalsourceid><addsrcrecordid>eNqNkc1u1DAUhSMEoqWw4QGQlwgpxY7jnyzLQIdWo1ZCIJaW47mZcUns1HaYzmPxhng67Swpd3PPlb5zdKVTFG8JPiV5Puob409Jhbl8VhwTUdNSME6fHzRjR8WrGG8wpk3VkJfFUUUZI3XVHBd_Zr111ugeRbtytsvSGUC-Q791NFOvAwK39GkNvc3QKvhNWqNOm-QD0m75P1gAA2MWZYVW4ACNvt8OPoxrG4eIrEOjThZcimhjs2ulYwreugQxWbf7LJ9D3mnKrvi6eNHpPsKbh31S_Dj_8n32tVxczy9mZ4vS1BjLsmHQMMKpNFLyljZYak0rTqluZd1IaTgYSRgmAJRQYQRmtWxBLkVbtxJTelK83-eOwd9O-Rc12Gig77UDP0VFOMc1ppzLp1FWNbImohIZ_bBHTfAxBujUGOygw1YRrHZtql2b6r7NDL97yJ3aAZYH9LG-DJA9sLE9bP8Rpc4uZ9ePoeXeY2OCu4NHh1-KCyqY-nk1V9-omC8uP39SnP4Fz9y9WA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1529841727</pqid></control><display><type>article</type><title>Clinical significance of vascular endothelial growth factor and vascular endothelial growth factor receptor-2 gene polymorphisms in patients with gastrointestinal stromal tumors</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Kang, Byung Woog ; Kim, Jong Gwang ; Chae, Yee Soo ; Bae, Han Ik ; Kwon, Ohkyoung ; Chung, Ho Young ; Yu, Wansik ; Song, Hong Suk ; Kang, Yu Na ; Ryu, Seung Wan ; Lee, Kyung Hee ; Bae, Young Kyung ; Choi, Joon Hyuk ; Kim, Se Won ; Ryoo, Hun-Mo ; Cho, Chang-Ho ; Chae, Hyun-Dong ; Park, Kyun Woo ; Gu, Mi Jin ; Bae, Byung-Jo</creator><creatorcontrib>Kang, Byung Woog ; Kim, Jong Gwang ; Chae, Yee Soo ; Bae, Han Ik ; Kwon, Ohkyoung ; Chung, Ho Young ; Yu, Wansik ; Song, Hong Suk ; Kang, Yu Na ; Ryu, Seung Wan ; Lee, Kyung Hee ; Bae, Young Kyung ; Choi, Joon Hyuk ; Kim, Se Won ; Ryoo, Hun-Mo ; Cho, Chang-Ho ; Chae, Hyun-Dong ; Park, Kyun Woo ; Gu, Mi Jin ; Bae, Byung-Jo</creatorcontrib><description>Aim
The vascular endothelial growth factor (VEGF) or its family might play role in tumor‐related angiogenesis in gastrointestinal stromal tumors (GIST), thereby affecting the prognosis. Accordingly, the present study analyzed the impact of VEGF and VEGF receptor‐2 (VEGFR‐2) gene polymorphisms on the prognosis for GIST patients.
Methods
In all, 213 consecutive patients with GIST from five medical centers were enrolled in the present study. The genomic DNA was extracted from paraffin‐embedded tumor tissue, and four VEGF (−2578C/A, −1498C/T, −634G/C, and +936C/T) and one VEGFR‐2 (+1416A/T) gene polymorphisms were determined using a Sequenom MassARRAY system.
Results
With a median follow up of 18.4 months, the estimated 5‐year relapse‐free survival and overall survival rates were 70 and 87%, respectively. In a multivariate analysis including age, sex, primary site of disease, pathology and risk stratification, no significant association was observed between the polymorphism of the VEGF and VEGFR‐2 genes and survival.
Conclusion
None of the five VEGF and VEGFR‐2 gene polymorphisms investigated in this study was found to be an independent prognostic marker for Korean patients with surgically resected GIST. However, further studies on a larger scale are warranted to clarify the role of VEGF and VEGFR gene polymorphisms as a prognostic biomarker for GIST patients.</description><identifier>ISSN: 1743-7555</identifier><identifier>EISSN: 1743-7563</identifier><identifier>DOI: 10.1111/ajco.12068</identifier><identifier>PMID: 23551429</identifier><language>eng</language><publisher>Australia: Blackwell Publishing Ltd</publisher><subject>Adult ; Aged ; Aged, 80 and over ; DNA, Neoplasm - genetics ; DNA, Neoplasm - isolation & purification ; Female ; Gastrointestinal Neoplasms - genetics ; gastrointestinal stromal tumor ; Gastrointestinal Stromal Tumors - genetics ; Humans ; Male ; Middle Aged ; Multivariate Analysis ; Paraffin Embedding ; Polymorphism, Genetic ; Polymorphism, Single Nucleotide ; Prognosis ; single nucleotide polymorphism ; vascular endothelial growth factor ; Vascular Endothelial Growth Factor A - genetics ; vascular endothelial growth factor receptor ; Vascular Endothelial Growth Factor Receptor-2 - genetics</subject><ispartof>Asia-Pacific journal of clinical oncology, 2014-06, Vol.10 (2), p.e40-e45</ispartof><rights>2013 Wiley Publishing Asia Pty Ltd</rights><rights>2013 Wiley Publishing Asia Pty Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4008-95e951638c886b3908aa32633ab84988c6ec81501ee3137c70548be8d7b4b8033</citedby><cites>FETCH-LOGICAL-c4008-95e951638c886b3908aa32633ab84988c6ec81501ee3137c70548be8d7b4b8033</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fajco.12068$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fajco.12068$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,777,781,1412,27905,27906,45555,45556</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23551429$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kang, Byung Woog</creatorcontrib><creatorcontrib>Kim, Jong Gwang</creatorcontrib><creatorcontrib>Chae, Yee Soo</creatorcontrib><creatorcontrib>Bae, Han Ik</creatorcontrib><creatorcontrib>Kwon, Ohkyoung</creatorcontrib><creatorcontrib>Chung, Ho Young</creatorcontrib><creatorcontrib>Yu, Wansik</creatorcontrib><creatorcontrib>Song, Hong Suk</creatorcontrib><creatorcontrib>Kang, Yu Na</creatorcontrib><creatorcontrib>Ryu, Seung Wan</creatorcontrib><creatorcontrib>Lee, Kyung Hee</creatorcontrib><creatorcontrib>Bae, Young Kyung</creatorcontrib><creatorcontrib>Choi, Joon Hyuk</creatorcontrib><creatorcontrib>Kim, Se Won</creatorcontrib><creatorcontrib>Ryoo, Hun-Mo</creatorcontrib><creatorcontrib>Cho, Chang-Ho</creatorcontrib><creatorcontrib>Chae, Hyun-Dong</creatorcontrib><creatorcontrib>Park, Kyun Woo</creatorcontrib><creatorcontrib>Gu, Mi Jin</creatorcontrib><creatorcontrib>Bae, Byung-Jo</creatorcontrib><title>Clinical significance of vascular endothelial growth factor and vascular endothelial growth factor receptor-2 gene polymorphisms in patients with gastrointestinal stromal tumors</title><title>Asia-Pacific journal of clinical oncology</title><addtitle>Asia-Pac J Clin Oncol</addtitle><description>Aim
The vascular endothelial growth factor (VEGF) or its family might play role in tumor‐related angiogenesis in gastrointestinal stromal tumors (GIST), thereby affecting the prognosis. Accordingly, the present study analyzed the impact of VEGF and VEGF receptor‐2 (VEGFR‐2) gene polymorphisms on the prognosis for GIST patients.
Methods
In all, 213 consecutive patients with GIST from five medical centers were enrolled in the present study. The genomic DNA was extracted from paraffin‐embedded tumor tissue, and four VEGF (−2578C/A, −1498C/T, −634G/C, and +936C/T) and one VEGFR‐2 (+1416A/T) gene polymorphisms were determined using a Sequenom MassARRAY system.
Results
With a median follow up of 18.4 months, the estimated 5‐year relapse‐free survival and overall survival rates were 70 and 87%, respectively. In a multivariate analysis including age, sex, primary site of disease, pathology and risk stratification, no significant association was observed between the polymorphism of the VEGF and VEGFR‐2 genes and survival.
Conclusion
None of the five VEGF and VEGFR‐2 gene polymorphisms investigated in this study was found to be an independent prognostic marker for Korean patients with surgically resected GIST. However, further studies on a larger scale are warranted to clarify the role of VEGF and VEGFR gene polymorphisms as a prognostic biomarker for GIST patients.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>DNA, Neoplasm - genetics</subject><subject>DNA, Neoplasm - isolation & purification</subject><subject>Female</subject><subject>Gastrointestinal Neoplasms - genetics</subject><subject>gastrointestinal stromal tumor</subject><subject>Gastrointestinal Stromal Tumors - genetics</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>Paraffin Embedding</subject><subject>Polymorphism, Genetic</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Prognosis</subject><subject>single nucleotide polymorphism</subject><subject>vascular endothelial growth factor</subject><subject>Vascular Endothelial Growth Factor A - genetics</subject><subject>vascular endothelial growth factor receptor</subject><subject>Vascular Endothelial Growth Factor Receptor-2 - genetics</subject><issn>1743-7555</issn><issn>1743-7563</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkc1u1DAUhSMEoqWw4QGQlwgpxY7jnyzLQIdWo1ZCIJaW47mZcUns1HaYzmPxhng67Swpd3PPlb5zdKVTFG8JPiV5Puob409Jhbl8VhwTUdNSME6fHzRjR8WrGG8wpk3VkJfFUUUZI3XVHBd_Zr111ugeRbtytsvSGUC-Q791NFOvAwK39GkNvc3QKvhNWqNOm-QD0m75P1gAA2MWZYVW4ACNvt8OPoxrG4eIrEOjThZcimhjs2ulYwreugQxWbf7LJ9D3mnKrvi6eNHpPsKbh31S_Dj_8n32tVxczy9mZ4vS1BjLsmHQMMKpNFLyljZYak0rTqluZd1IaTgYSRgmAJRQYQRmtWxBLkVbtxJTelK83-eOwd9O-Rc12Gig77UDP0VFOMc1ppzLp1FWNbImohIZ_bBHTfAxBujUGOygw1YRrHZtql2b6r7NDL97yJ3aAZYH9LG-DJA9sLE9bP8Rpc4uZ9ePoeXeY2OCu4NHh1-KCyqY-nk1V9-omC8uP39SnP4Fz9y9WA</recordid><startdate>201406</startdate><enddate>201406</enddate><creator>Kang, Byung Woog</creator><creator>Kim, Jong Gwang</creator><creator>Chae, Yee Soo</creator><creator>Bae, Han Ik</creator><creator>Kwon, Ohkyoung</creator><creator>Chung, Ho Young</creator><creator>Yu, Wansik</creator><creator>Song, Hong Suk</creator><creator>Kang, Yu Na</creator><creator>Ryu, Seung Wan</creator><creator>Lee, Kyung Hee</creator><creator>Bae, Young Kyung</creator><creator>Choi, Joon Hyuk</creator><creator>Kim, Se Won</creator><creator>Ryoo, Hun-Mo</creator><creator>Cho, Chang-Ho</creator><creator>Chae, Hyun-Dong</creator><creator>Park, Kyun Woo</creator><creator>Gu, Mi Jin</creator><creator>Bae, Byung-Jo</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope></search><sort><creationdate>201406</creationdate><title>Clinical significance of vascular endothelial growth factor and vascular endothelial growth factor receptor-2 gene polymorphisms in patients with gastrointestinal stromal tumors</title><author>Kang, Byung Woog ; Kim, Jong Gwang ; Chae, Yee Soo ; Bae, Han Ik ; Kwon, Ohkyoung ; Chung, Ho Young ; Yu, Wansik ; Song, Hong Suk ; Kang, Yu Na ; Ryu, Seung Wan ; Lee, Kyung Hee ; Bae, Young Kyung ; Choi, Joon Hyuk ; Kim, Se Won ; Ryoo, Hun-Mo ; Cho, Chang-Ho ; Chae, Hyun-Dong ; Park, Kyun Woo ; Gu, Mi Jin ; Bae, Byung-Jo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4008-95e951638c886b3908aa32633ab84988c6ec81501ee3137c70548be8d7b4b8033</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>DNA, Neoplasm - genetics</topic><topic>DNA, Neoplasm - isolation & purification</topic><topic>Female</topic><topic>Gastrointestinal Neoplasms - genetics</topic><topic>gastrointestinal stromal tumor</topic><topic>Gastrointestinal Stromal Tumors - genetics</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Multivariate Analysis</topic><topic>Paraffin Embedding</topic><topic>Polymorphism, Genetic</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Prognosis</topic><topic>single nucleotide polymorphism</topic><topic>vascular endothelial growth factor</topic><topic>Vascular Endothelial Growth Factor A - genetics</topic><topic>vascular endothelial growth factor receptor</topic><topic>Vascular Endothelial Growth Factor Receptor-2 - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kang, Byung Woog</creatorcontrib><creatorcontrib>Kim, Jong Gwang</creatorcontrib><creatorcontrib>Chae, Yee Soo</creatorcontrib><creatorcontrib>Bae, Han Ik</creatorcontrib><creatorcontrib>Kwon, Ohkyoung</creatorcontrib><creatorcontrib>Chung, Ho Young</creatorcontrib><creatorcontrib>Yu, Wansik</creatorcontrib><creatorcontrib>Song, Hong Suk</creatorcontrib><creatorcontrib>Kang, Yu Na</creatorcontrib><creatorcontrib>Ryu, Seung Wan</creatorcontrib><creatorcontrib>Lee, Kyung Hee</creatorcontrib><creatorcontrib>Bae, Young Kyung</creatorcontrib><creatorcontrib>Choi, Joon Hyuk</creatorcontrib><creatorcontrib>Kim, Se Won</creatorcontrib><creatorcontrib>Ryoo, Hun-Mo</creatorcontrib><creatorcontrib>Cho, Chang-Ho</creatorcontrib><creatorcontrib>Chae, Hyun-Dong</creatorcontrib><creatorcontrib>Park, Kyun Woo</creatorcontrib><creatorcontrib>Gu, Mi Jin</creatorcontrib><creatorcontrib>Bae, Byung-Jo</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><jtitle>Asia-Pacific journal of clinical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kang, Byung Woog</au><au>Kim, Jong Gwang</au><au>Chae, Yee Soo</au><au>Bae, Han Ik</au><au>Kwon, Ohkyoung</au><au>Chung, Ho Young</au><au>Yu, Wansik</au><au>Song, Hong Suk</au><au>Kang, Yu Na</au><au>Ryu, Seung Wan</au><au>Lee, Kyung Hee</au><au>Bae, Young Kyung</au><au>Choi, Joon Hyuk</au><au>Kim, Se Won</au><au>Ryoo, Hun-Mo</au><au>Cho, Chang-Ho</au><au>Chae, Hyun-Dong</au><au>Park, Kyun Woo</au><au>Gu, Mi Jin</au><au>Bae, Byung-Jo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical significance of vascular endothelial growth factor and vascular endothelial growth factor receptor-2 gene polymorphisms in patients with gastrointestinal stromal tumors</atitle><jtitle>Asia-Pacific journal of clinical oncology</jtitle><addtitle>Asia-Pac J Clin Oncol</addtitle><date>2014-06</date><risdate>2014</risdate><volume>10</volume><issue>2</issue><spage>e40</spage><epage>e45</epage><pages>e40-e45</pages><issn>1743-7555</issn><eissn>1743-7563</eissn><abstract>Aim
The vascular endothelial growth factor (VEGF) or its family might play role in tumor‐related angiogenesis in gastrointestinal stromal tumors (GIST), thereby affecting the prognosis. Accordingly, the present study analyzed the impact of VEGF and VEGF receptor‐2 (VEGFR‐2) gene polymorphisms on the prognosis for GIST patients.
Methods
In all, 213 consecutive patients with GIST from five medical centers were enrolled in the present study. The genomic DNA was extracted from paraffin‐embedded tumor tissue, and four VEGF (−2578C/A, −1498C/T, −634G/C, and +936C/T) and one VEGFR‐2 (+1416A/T) gene polymorphisms were determined using a Sequenom MassARRAY system.
Results
With a median follow up of 18.4 months, the estimated 5‐year relapse‐free survival and overall survival rates were 70 and 87%, respectively. In a multivariate analysis including age, sex, primary site of disease, pathology and risk stratification, no significant association was observed between the polymorphism of the VEGF and VEGFR‐2 genes and survival.
Conclusion
None of the five VEGF and VEGFR‐2 gene polymorphisms investigated in this study was found to be an independent prognostic marker for Korean patients with surgically resected GIST. However, further studies on a larger scale are warranted to clarify the role of VEGF and VEGFR gene polymorphisms as a prognostic biomarker for GIST patients.</abstract><cop>Australia</cop><pub>Blackwell Publishing Ltd</pub><pmid>23551429</pmid><doi>10.1111/ajco.12068</doi><tpages>6</tpages></addata></record> |
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| identifier | ISSN: 1743-7555 |
| ispartof | Asia-Pacific journal of clinical oncology, 2014-06, Vol.10 (2), p.e40-e45 |
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| subjects | Adult Aged Aged, 80 and over DNA, Neoplasm - genetics DNA, Neoplasm - isolation & purification Female Gastrointestinal Neoplasms - genetics gastrointestinal stromal tumor Gastrointestinal Stromal Tumors - genetics Humans Male Middle Aged Multivariate Analysis Paraffin Embedding Polymorphism, Genetic Polymorphism, Single Nucleotide Prognosis single nucleotide polymorphism vascular endothelial growth factor Vascular Endothelial Growth Factor A - genetics vascular endothelial growth factor receptor Vascular Endothelial Growth Factor Receptor-2 - genetics |
| title | Clinical significance of vascular endothelial growth factor and vascular endothelial growth factor receptor-2 gene polymorphisms in patients with gastrointestinal stromal tumors |
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