N-myc downstream-regulated gene 2 (NDRG2) suppresses the epithelial–mesenchymal transition (EMT) in breast cancer cells via STAT3/Snail signaling

Highlights • NDRG2 overexpression inhibits Snail expression in breast cancer cells. • NDRG2 overexpression reduces activation of STAT3. • NDRG2 interrupts the promoter activation of Snail via STAT3 signaling. • The repression of STAT3/Snail signaling by NDRG2 results in attenuation of invasion. • si...

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Veröffentlicht in:	Cancer letters 2014-11, Vol.354 (1), p.33-42
Hauptverfasser:	Kim, Myung-Jin, Lim, Jihyun, Yang, Young, Lee, Myeong-Sok, Lim, Jong-Seok
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Breast cancer Cell adhesion & migration Cell growth Cell Line, Tumor Cell Movement Cloning EMT Epidermal growth factor Epithelial-Mesenchymal Transition Gene expression Gene Expression Regulation, Neoplastic HEK293 Cells Hematology, Oncology and Palliative Medicine Humans MCF-7 Cells Metastasis NDRG2 Neoplasm Invasiveness Phosphorylation Promoter Regions, Genetic Proteins RNA, Small Interfering - metabolism Signal Transduction Snail Snail Family Transcription Factors STAT3 STAT3 Transcription Factor - metabolism Studies Transcription factors Transcription Factors - metabolism Tumor Suppressor Proteins - metabolism Tumors Wound Healing
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Zusammenfassung:	Highlights • NDRG2 overexpression inhibits Snail expression in breast cancer cells. • NDRG2 overexpression reduces activation of STAT3. • NDRG2 interrupts the promoter activation of Snail via STAT3 signaling. • The repression of STAT3/Snail signaling by NDRG2 results in attenuation of invasion. • siRNA-mediated knockdown of NDRG2 restores Snail expression, migration, and invasion.
ISSN:	0304-3835 1872-7980
DOI:	10.1016/j.canlet.2014.06.023