Research on choleretic effect of menthol, menthone, pluegone, isomenthone, and limonene in DanShu capsule
Danshu capsule (DSC) is a medicinal compound in traditional Chinese medicine (TCM). It is commonly used for the treatment of acute & chronic cholecystitis as well as choleithiasis. To study its choleretic effect, healthy rats were randomly divided into DSC high (DSCH, 900mg/kg), medium (DSCM, 45...
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| Veröffentlicht in: | International immunopharmacology 2015-02, Vol.24 (2), p.191-197 |
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| creator | Hu, Guanying Yuan, Xing Zhang, Sanyin Wang, Ruru Yang, Miao Wu, Chunjie Wu, Zhigang Ke, Xiao |
| description | Danshu capsule (DSC) is a medicinal compound in traditional Chinese medicine (TCM). It is commonly used for the treatment of acute & chronic cholecystitis as well as choleithiasis. To study its choleretic effect, healthy rats were randomly divided into DSC high (DSCH, 900mg/kg), medium (DSCM, 450mg/kg), and low (DSCL, 225mg/kg) group, Xiaoyan Lidan tablet (XYLDT, 750mg/kg), and saline group. The bile was collected for 1h after 20-minute stabilization as the base level, and at 1h, 2h, 3h, and 4h after drug administration, respectively. Bile volume, total cholesterol, and total bile acid were measured at each time point. The results revealed that DSC significantly stimulated bile secretion, decreased total cholesterol level and increased total bile acid level. Therefore, it had choleretic effects. To identify the active components contributing to its choleretic effects, five major constituents which are menthol (39.33mg/kg), menthone (18.02mg/kg), isomenthone (8.18mg/kg), pluegone (3.31mg/kg), and limonene (4.39mg/kg) were tested on our rat model. The results showed that menthol and limonene could promote bile secretion when compared to DSC treatment (p > 0.05); Menthol, menthol and limonene could significantly decrease total cholesterol level (p |
| doi_str_mv | 10.1016/j.intimp.2014.12.001 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1660401485</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1660401485</sourcerecordid><originalsourceid>FETCH-LOGICAL-c340t-acd1da038ba97fd786b80dc7d20e06c05e148dac5d8e4196afd1a37de4bc90dc3</originalsourceid><addsrcrecordid>eNqNkUtPwzAQhC0Eorz-AUI-cmiCN3Hs5Ih4S0hIPM6Wa2-oq8QJcXLg3-PSAldOO1p9syvNEHIKLAUG4mKVOj-6tk8zBjyFLGUMdsgBlLJMQLJiN-pCyKSQopqRwxBWEZCMwz6ZZQWvKpmJA-KeMaAezJJ2nppl1-CAozMU6xrNSLuatujHuJ9vhcc57ZsJ37-VC93fWntLG9dG7ZE6T6-1f1lO1Og-TA0ek71aNwFPtvOIvN3evF7dJ49Pdw9Xl4-JyTkbE20sWM3ycqErWVtZikXJrJE2Y8iEYQUCL602hS2RQyV0bUHn0iJfmCqC-RE539zth-5jwjCq1gWDTaM9dlNQIATjMbKy-Ada5JBxkeUR5RvUDF0IA9aqH1yrh08FTK37UCu16UOt-1CQqRh3tJ1tP0yLFu2v6aeA_AuWsInu</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1653124623</pqid></control><display><type>article</type><title>Research on choleretic effect of menthol, menthone, pluegone, isomenthone, and limonene in DanShu capsule</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals Complete</source><creator>Hu, Guanying ; Yuan, Xing ; Zhang, Sanyin ; Wang, Ruru ; Yang, Miao ; Wu, Chunjie ; Wu, Zhigang ; Ke, Xiao</creator><creatorcontrib>Hu, Guanying ; Yuan, Xing ; Zhang, Sanyin ; Wang, Ruru ; Yang, Miao ; Wu, Chunjie ; Wu, Zhigang ; Ke, Xiao</creatorcontrib><description>Danshu capsule (DSC) is a medicinal compound in traditional Chinese medicine (TCM). It is commonly used for the treatment of acute & chronic cholecystitis as well as choleithiasis. To study its choleretic effect, healthy rats were randomly divided into DSC high (DSCH, 900mg/kg), medium (DSCM, 450mg/kg), and low (DSCL, 225mg/kg) group, Xiaoyan Lidan tablet (XYLDT, 750mg/kg), and saline group. The bile was collected for 1h after 20-minute stabilization as the base level, and at 1h, 2h, 3h, and 4h after drug administration, respectively. Bile volume, total cholesterol, and total bile acid were measured at each time point. The results revealed that DSC significantly stimulated bile secretion, decreased total cholesterol level and increased total bile acid level. Therefore, it had choleretic effects. To identify the active components contributing to its choleretic effects, five major constituents which are menthol (39.33mg/kg), menthone (18.02mg/kg), isomenthone (8.18mg/kg), pluegone (3.31mg/kg), and limonene (4.39mg/kg) were tested on our rat model. The results showed that menthol and limonene could promote bile secretion when compared to DSC treatment (p > 0.05); Menthol, menthol and limonene could significantly decrease total cholesterol level (p<0.05 or p<0.01) as well as increase total bile acid level (p<0.05 or p<0.01); Isomenthone, as a isomer of menthone, existed slightly choleretic effects; Pluegone had no obvious role in bile acid efflux. These findings indicated that the choleretic effects of DSC may be attributed mainly to its three major constituents: menthol, menthone and limonene.</description><identifier>ISSN: 1567-5769</identifier><identifier>EISSN: 1878-1705</identifier><identifier>DOI: 10.1016/j.intimp.2014.12.001</identifier><identifier>PMID: 25499726</identifier><language>eng</language><publisher>Netherlands</publisher><subject>Animals ; Bile - drug effects ; Bile - metabolism ; Bile Acids and Salts - metabolism ; Cholagogues and Choleretics - therapeutic use ; Cholecystitis - drug therapy ; Cholelithiasis - drug therapy ; Cholesterol - metabolism ; Complex Mixtures - therapeutic use ; Cyclohexenes - administration & dosage ; Humans ; Limonene ; Male ; Medicine, Chinese Traditional ; Menthol - administration & dosage ; Monoterpenes - administration & dosage ; Rats ; Rats, Sprague-Dawley ; Terpenes - administration & dosage</subject><ispartof>International immunopharmacology, 2015-02, Vol.24 (2), p.191-197</ispartof><rights>Crown Copyright © 2014. Published by Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c340t-acd1da038ba97fd786b80dc7d20e06c05e148dac5d8e4196afd1a37de4bc90dc3</citedby><cites>FETCH-LOGICAL-c340t-acd1da038ba97fd786b80dc7d20e06c05e148dac5d8e4196afd1a37de4bc90dc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25499726$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hu, Guanying</creatorcontrib><creatorcontrib>Yuan, Xing</creatorcontrib><creatorcontrib>Zhang, Sanyin</creatorcontrib><creatorcontrib>Wang, Ruru</creatorcontrib><creatorcontrib>Yang, Miao</creatorcontrib><creatorcontrib>Wu, Chunjie</creatorcontrib><creatorcontrib>Wu, Zhigang</creatorcontrib><creatorcontrib>Ke, Xiao</creatorcontrib><title>Research on choleretic effect of menthol, menthone, pluegone, isomenthone, and limonene in DanShu capsule</title><title>International immunopharmacology</title><addtitle>Int Immunopharmacol</addtitle><description>Danshu capsule (DSC) is a medicinal compound in traditional Chinese medicine (TCM). It is commonly used for the treatment of acute & chronic cholecystitis as well as choleithiasis. To study its choleretic effect, healthy rats were randomly divided into DSC high (DSCH, 900mg/kg), medium (DSCM, 450mg/kg), and low (DSCL, 225mg/kg) group, Xiaoyan Lidan tablet (XYLDT, 750mg/kg), and saline group. The bile was collected for 1h after 20-minute stabilization as the base level, and at 1h, 2h, 3h, and 4h after drug administration, respectively. Bile volume, total cholesterol, and total bile acid were measured at each time point. The results revealed that DSC significantly stimulated bile secretion, decreased total cholesterol level and increased total bile acid level. Therefore, it had choleretic effects. To identify the active components contributing to its choleretic effects, five major constituents which are menthol (39.33mg/kg), menthone (18.02mg/kg), isomenthone (8.18mg/kg), pluegone (3.31mg/kg), and limonene (4.39mg/kg) were tested on our rat model. The results showed that menthol and limonene could promote bile secretion when compared to DSC treatment (p > 0.05); Menthol, menthol and limonene could significantly decrease total cholesterol level (p<0.05 or p<0.01) as well as increase total bile acid level (p<0.05 or p<0.01); Isomenthone, as a isomer of menthone, existed slightly choleretic effects; Pluegone had no obvious role in bile acid efflux. These findings indicated that the choleretic effects of DSC may be attributed mainly to its three major constituents: menthol, menthone and limonene.</description><subject>Animals</subject><subject>Bile - drug effects</subject><subject>Bile - metabolism</subject><subject>Bile Acids and Salts - metabolism</subject><subject>Cholagogues and Choleretics - therapeutic use</subject><subject>Cholecystitis - drug therapy</subject><subject>Cholelithiasis - drug therapy</subject><subject>Cholesterol - metabolism</subject><subject>Complex Mixtures - therapeutic use</subject><subject>Cyclohexenes - administration & dosage</subject><subject>Humans</subject><subject>Limonene</subject><subject>Male</subject><subject>Medicine, Chinese Traditional</subject><subject>Menthol - administration & dosage</subject><subject>Monoterpenes - administration & dosage</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Terpenes - administration & dosage</subject><issn>1567-5769</issn><issn>1878-1705</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkUtPwzAQhC0Eorz-AUI-cmiCN3Hs5Ih4S0hIPM6Wa2-oq8QJcXLg3-PSAldOO1p9syvNEHIKLAUG4mKVOj-6tk8zBjyFLGUMdsgBlLJMQLJiN-pCyKSQopqRwxBWEZCMwz6ZZQWvKpmJA-KeMaAezJJ2nppl1-CAozMU6xrNSLuatujHuJ9vhcc57ZsJ37-VC93fWntLG9dG7ZE6T6-1f1lO1Og-TA0ek71aNwFPtvOIvN3evF7dJ49Pdw9Xl4-JyTkbE20sWM3ycqErWVtZikXJrJE2Y8iEYQUCL602hS2RQyV0bUHn0iJfmCqC-RE539zth-5jwjCq1gWDTaM9dlNQIATjMbKy-Ada5JBxkeUR5RvUDF0IA9aqH1yrh08FTK37UCu16UOt-1CQqRh3tJ1tP0yLFu2v6aeA_AuWsInu</recordid><startdate>20150201</startdate><enddate>20150201</enddate><creator>Hu, Guanying</creator><creator>Yuan, Xing</creator><creator>Zhang, Sanyin</creator><creator>Wang, Ruru</creator><creator>Yang, Miao</creator><creator>Wu, Chunjie</creator><creator>Wu, Zhigang</creator><creator>Ke, Xiao</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7T5</scope><scope>H94</scope></search><sort><creationdate>20150201</creationdate><title>Research on choleretic effect of menthol, menthone, pluegone, isomenthone, and limonene in DanShu capsule</title><author>Hu, Guanying ; Yuan, Xing ; Zhang, Sanyin ; Wang, Ruru ; Yang, Miao ; Wu, Chunjie ; Wu, Zhigang ; Ke, Xiao</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c340t-acd1da038ba97fd786b80dc7d20e06c05e148dac5d8e4196afd1a37de4bc90dc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Animals</topic><topic>Bile - drug effects</topic><topic>Bile - metabolism</topic><topic>Bile Acids and Salts - metabolism</topic><topic>Cholagogues and Choleretics - therapeutic use</topic><topic>Cholecystitis - drug therapy</topic><topic>Cholelithiasis - drug therapy</topic><topic>Cholesterol - metabolism</topic><topic>Complex Mixtures - therapeutic use</topic><topic>Cyclohexenes - administration & dosage</topic><topic>Humans</topic><topic>Limonene</topic><topic>Male</topic><topic>Medicine, Chinese Traditional</topic><topic>Menthol - administration & dosage</topic><topic>Monoterpenes - administration & dosage</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Terpenes - administration & dosage</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hu, Guanying</creatorcontrib><creatorcontrib>Yuan, Xing</creatorcontrib><creatorcontrib>Zhang, Sanyin</creatorcontrib><creatorcontrib>Wang, Ruru</creatorcontrib><creatorcontrib>Yang, Miao</creatorcontrib><creatorcontrib>Wu, Chunjie</creatorcontrib><creatorcontrib>Wu, Zhigang</creatorcontrib><creatorcontrib>Ke, Xiao</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>International immunopharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hu, Guanying</au><au>Yuan, Xing</au><au>Zhang, Sanyin</au><au>Wang, Ruru</au><au>Yang, Miao</au><au>Wu, Chunjie</au><au>Wu, Zhigang</au><au>Ke, Xiao</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Research on choleretic effect of menthol, menthone, pluegone, isomenthone, and limonene in DanShu capsule</atitle><jtitle>International immunopharmacology</jtitle><addtitle>Int Immunopharmacol</addtitle><date>2015-02-01</date><risdate>2015</risdate><volume>24</volume><issue>2</issue><spage>191</spage><epage>197</epage><pages>191-197</pages><issn>1567-5769</issn><eissn>1878-1705</eissn><abstract>Danshu capsule (DSC) is a medicinal compound in traditional Chinese medicine (TCM). It is commonly used for the treatment of acute & chronic cholecystitis as well as choleithiasis. To study its choleretic effect, healthy rats were randomly divided into DSC high (DSCH, 900mg/kg), medium (DSCM, 450mg/kg), and low (DSCL, 225mg/kg) group, Xiaoyan Lidan tablet (XYLDT, 750mg/kg), and saline group. The bile was collected for 1h after 20-minute stabilization as the base level, and at 1h, 2h, 3h, and 4h after drug administration, respectively. Bile volume, total cholesterol, and total bile acid were measured at each time point. The results revealed that DSC significantly stimulated bile secretion, decreased total cholesterol level and increased total bile acid level. Therefore, it had choleretic effects. To identify the active components contributing to its choleretic effects, five major constituents which are menthol (39.33mg/kg), menthone (18.02mg/kg), isomenthone (8.18mg/kg), pluegone (3.31mg/kg), and limonene (4.39mg/kg) were tested on our rat model. The results showed that menthol and limonene could promote bile secretion when compared to DSC treatment (p > 0.05); Menthol, menthol and limonene could significantly decrease total cholesterol level (p<0.05 or p<0.01) as well as increase total bile acid level (p<0.05 or p<0.01); Isomenthone, as a isomer of menthone, existed slightly choleretic effects; Pluegone had no obvious role in bile acid efflux. These findings indicated that the choleretic effects of DSC may be attributed mainly to its three major constituents: menthol, menthone and limonene.</abstract><cop>Netherlands</cop><pmid>25499726</pmid><doi>10.1016/j.intimp.2014.12.001</doi><tpages>7</tpages></addata></record> |
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| subjects | Animals Bile - drug effects Bile - metabolism Bile Acids and Salts - metabolism Cholagogues and Choleretics - therapeutic use Cholecystitis - drug therapy Cholelithiasis - drug therapy Cholesterol - metabolism Complex Mixtures - therapeutic use Cyclohexenes - administration & dosage Humans Limonene Male Medicine, Chinese Traditional Menthol - administration & dosage Monoterpenes - administration & dosage Rats Rats, Sprague-Dawley Terpenes - administration & dosage |
| title | Research on choleretic effect of menthol, menthone, pluegone, isomenthone, and limonene in DanShu capsule |
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