Hippocampal volume and shape in pure subcortical vascular dementia
Abstract The purposes of the present study were to explore whether hippocampal atrophy exists in pure subcortical vascular dementia (SVaD) as defined by negative11 C-Pittsburg compound-B (PiB− ) positron emission tomography and to compare hippocampal volume and shape between PiB− SVaD and PiB positi...
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| Veröffentlicht in: | Neurobiology of aging 2015, Vol.36 (1), p.485-491 |
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| creator | Kim, Geon Ha Lee, Jae Hong Seo, Sang Won Kim, Jeong Hun Seong, Joon-Kyung Ye, Byoung Seok Cho, Hanna Noh, Young Kim, Hee Jin Yoon, Cindy W Oh, Seung Jun Kim, Jae Seung Choe, Yearn Seong Lee, Kyung Han Kim, Sung Tae Hwang, Jung Won Jeong, Jee Hyang Na, Duk L |
| description | Abstract The purposes of the present study were to explore whether hippocampal atrophy exists in pure subcortical vascular dementia (SVaD) as defined by negative11 C-Pittsburg compound-B (PiB− ) positron emission tomography and to compare hippocampal volume and shape between PiB− SVaD and PiB positive (PiB+ ) Alzheimer's disease (AD) dementia. Hippocampal volume and shape were compared among 40 patients with PiB− SVaD, 34 with PiB+ AD, and 21 elderly with normal cognitive function (NC). The normalized hippocampal volume of PiB− SVaD was significantly smaller than NC but larger than that of PiB+ AD (NC > PiB− SVaD > PiB+ AD). Both PiB− SVaD and PiB+ AD patients had deflated shape changes in the cornus ammonis (CA) 1 and subiculum compared with NC. However, direct comparison between PiB− SVaD and PiB+ AD demonstrated more inward deformity in the subiculum of the left hippocampus in PiB+ AD. PiB− SVaD patients did have smaller hippocampal volumes and inward shape change on CA 1 and subiculum compared with NC, suggesting that cumulative ischemia without amyloid pathology could lead to hippocampal atrophy and shape changes. |
| doi_str_mv | 10.1016/j.neurobiolaging.2014.08.009 |
| format | Article |
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Hippocampal volume and shape were compared among 40 patients with PiB− SVaD, 34 with PiB+ AD, and 21 elderly with normal cognitive function (NC). The normalized hippocampal volume of PiB− SVaD was significantly smaller than NC but larger than that of PiB+ AD (NC > PiB− SVaD > PiB+ AD). Both PiB− SVaD and PiB+ AD patients had deflated shape changes in the cornus ammonis (CA) 1 and subiculum compared with NC. However, direct comparison between PiB− SVaD and PiB+ AD demonstrated more inward deformity in the subiculum of the left hippocampus in PiB+ AD. PiB− SVaD patients did have smaller hippocampal volumes and inward shape change on CA 1 and subiculum compared with NC, suggesting that cumulative ischemia without amyloid pathology could lead to hippocampal atrophy and shape changes.</description><identifier>ISSN: 0197-4580</identifier><identifier>EISSN: 1558-1497</identifier><identifier>DOI: 10.1016/j.neurobiolaging.2014.08.009</identifier><identifier>PMID: 25444608</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Aged ; Aged, 80 and over ; Alzheimer Disease - diagnostic imaging ; Alzheimer Disease - pathology ; Alzheimer's disease ; Aniline Compounds ; Atrophy ; Carbon Radioisotopes ; Cognition ; Dementia, Vascular - diagnostic imaging ; Dementia, Vascular - pathology ; Dementia, Vascular - psychology ; Female ; Hippocampus ; Hippocampus - diagnostic imaging ; Hippocampus - pathology ; Humans ; Internal Medicine ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Neurology ; PiB-PET ; Positron-Emission Tomography ; Radiopharmaceuticals ; Thiazoles ; Vascular dementia</subject><ispartof>Neurobiology of aging, 2015, Vol.36 (1), p.485-491</ispartof><rights>Elsevier Inc.</rights><rights>2015 Elsevier Inc.</rights><rights>Copyright © 2015 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c540t-a17e6778d930d05caec726d07f6c32c4729341d566fef4d71c42c03d33eff9ff3</citedby><cites>FETCH-LOGICAL-c540t-a17e6778d930d05caec726d07f6c32c4729341d566fef4d71c42c03d33eff9ff3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.neurobiolaging.2014.08.009$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,4025,27928,27929,27930,46000</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25444608$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kim, Geon Ha</creatorcontrib><creatorcontrib>Lee, Jae Hong</creatorcontrib><creatorcontrib>Seo, Sang Won</creatorcontrib><creatorcontrib>Kim, Jeong Hun</creatorcontrib><creatorcontrib>Seong, Joon-Kyung</creatorcontrib><creatorcontrib>Ye, Byoung Seok</creatorcontrib><creatorcontrib>Cho, Hanna</creatorcontrib><creatorcontrib>Noh, Young</creatorcontrib><creatorcontrib>Kim, Hee Jin</creatorcontrib><creatorcontrib>Yoon, Cindy W</creatorcontrib><creatorcontrib>Oh, Seung Jun</creatorcontrib><creatorcontrib>Kim, Jae Seung</creatorcontrib><creatorcontrib>Choe, Yearn Seong</creatorcontrib><creatorcontrib>Lee, Kyung Han</creatorcontrib><creatorcontrib>Kim, Sung Tae</creatorcontrib><creatorcontrib>Hwang, Jung Won</creatorcontrib><creatorcontrib>Jeong, Jee Hyang</creatorcontrib><creatorcontrib>Na, Duk L</creatorcontrib><title>Hippocampal volume and shape in pure subcortical vascular dementia</title><title>Neurobiology of aging</title><addtitle>Neurobiol Aging</addtitle><description>Abstract The purposes of the present study were to explore whether hippocampal atrophy exists in pure subcortical vascular dementia (SVaD) as defined by negative11 C-Pittsburg compound-B (PiB− ) positron emission tomography and to compare hippocampal volume and shape between PiB− SVaD and PiB positive (PiB+ ) Alzheimer's disease (AD) dementia. Hippocampal volume and shape were compared among 40 patients with PiB− SVaD, 34 with PiB+ AD, and 21 elderly with normal cognitive function (NC). The normalized hippocampal volume of PiB− SVaD was significantly smaller than NC but larger than that of PiB+ AD (NC > PiB− SVaD > PiB+ AD). Both PiB− SVaD and PiB+ AD patients had deflated shape changes in the cornus ammonis (CA) 1 and subiculum compared with NC. However, direct comparison between PiB− SVaD and PiB+ AD demonstrated more inward deformity in the subiculum of the left hippocampus in PiB+ AD. PiB− SVaD patients did have smaller hippocampal volumes and inward shape change on CA 1 and subiculum compared with NC, suggesting that cumulative ischemia without amyloid pathology could lead to hippocampal atrophy and shape changes.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Alzheimer Disease - diagnostic imaging</subject><subject>Alzheimer Disease - pathology</subject><subject>Alzheimer's disease</subject><subject>Aniline Compounds</subject><subject>Atrophy</subject><subject>Carbon Radioisotopes</subject><subject>Cognition</subject><subject>Dementia, Vascular - diagnostic imaging</subject><subject>Dementia, Vascular - pathology</subject><subject>Dementia, Vascular - psychology</subject><subject>Female</subject><subject>Hippocampus</subject><subject>Hippocampus - diagnostic imaging</subject><subject>Hippocampus - pathology</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neurology</subject><subject>PiB-PET</subject><subject>Positron-Emission Tomography</subject><subject>Radiopharmaceuticals</subject><subject>Thiazoles</subject><subject>Vascular dementia</subject><issn>0197-4580</issn><issn>1558-1497</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkU2L1TAUhoMozp2PvyBduHDTetJ8tSCCDjOOMOBCXYfc5GTMtU1q0g7Mv7fljoKuZnU2z3lfeF5CXlNoKFD59tBEXHLahzSYuxDvmhYob6BrAPpnZEeF6GrKe_Wc7ID2quaigxNyWsoBABRX8iU5aQXnXEK3Ix9vwjQla8bJDNV9GpYRKxNdVX6YCasQq2nJWJVlb1Oeg90gU-wymFw5HDHOwZyTF94MBS8e7xn5fn317fKmvv3y6fPlh9vaCg5zbahCqVTnegYOhDVoVSsdKC8tay1Xbc84dUJKj547RS1vLTDHGHrfe8_OyJtj7pTTrwXLrMdQLA6DiZiWoqmUwIFSrp6AMiVE33FY0XdH1OZUSkavpxxGkx80Bb0J1wf9r3C9CdfQ6VX4-v7qsWnZj-j-Pv8xvALXRwBXNfcBsy42YLToQkY7a5fCU5ve_xdkhxC3SX7iA5ZDWnJc9WuqS6tBf93G37anHEC0LWO_AQxcrxg</recordid><startdate>2015</startdate><enddate>2015</enddate><creator>Kim, Geon Ha</creator><creator>Lee, Jae Hong</creator><creator>Seo, Sang Won</creator><creator>Kim, Jeong Hun</creator><creator>Seong, Joon-Kyung</creator><creator>Ye, Byoung Seok</creator><creator>Cho, Hanna</creator><creator>Noh, Young</creator><creator>Kim, Hee Jin</creator><creator>Yoon, Cindy W</creator><creator>Oh, Seung Jun</creator><creator>Kim, Jae Seung</creator><creator>Choe, Yearn Seong</creator><creator>Lee, Kyung Han</creator><creator>Kim, Sung Tae</creator><creator>Hwang, Jung Won</creator><creator>Jeong, Jee Hyang</creator><creator>Na, Duk L</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TK</scope></search><sort><creationdate>2015</creationdate><title>Hippocampal volume and shape in pure subcortical vascular dementia</title><author>Kim, Geon Ha ; Lee, Jae Hong ; Seo, Sang Won ; Kim, Jeong Hun ; Seong, Joon-Kyung ; Ye, Byoung Seok ; Cho, Hanna ; Noh, Young ; Kim, Hee Jin ; Yoon, Cindy W ; Oh, Seung Jun ; Kim, Jae Seung ; Choe, Yearn Seong ; Lee, Kyung Han ; Kim, Sung Tae ; Hwang, Jung Won ; Jeong, Jee Hyang ; Na, Duk L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c540t-a17e6778d930d05caec726d07f6c32c4729341d566fef4d71c42c03d33eff9ff3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Alzheimer Disease - diagnostic imaging</topic><topic>Alzheimer Disease - pathology</topic><topic>Alzheimer's disease</topic><topic>Aniline Compounds</topic><topic>Atrophy</topic><topic>Carbon Radioisotopes</topic><topic>Cognition</topic><topic>Dementia, Vascular - diagnostic imaging</topic><topic>Dementia, Vascular - pathology</topic><topic>Dementia, Vascular - psychology</topic><topic>Female</topic><topic>Hippocampus</topic><topic>Hippocampus - diagnostic imaging</topic><topic>Hippocampus - pathology</topic><topic>Humans</topic><topic>Internal Medicine</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Neurology</topic><topic>PiB-PET</topic><topic>Positron-Emission Tomography</topic><topic>Radiopharmaceuticals</topic><topic>Thiazoles</topic><topic>Vascular dementia</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, Geon Ha</creatorcontrib><creatorcontrib>Lee, Jae Hong</creatorcontrib><creatorcontrib>Seo, Sang Won</creatorcontrib><creatorcontrib>Kim, Jeong Hun</creatorcontrib><creatorcontrib>Seong, Joon-Kyung</creatorcontrib><creatorcontrib>Ye, Byoung Seok</creatorcontrib><creatorcontrib>Cho, Hanna</creatorcontrib><creatorcontrib>Noh, Young</creatorcontrib><creatorcontrib>Kim, Hee Jin</creatorcontrib><creatorcontrib>Yoon, Cindy W</creatorcontrib><creatorcontrib>Oh, Seung Jun</creatorcontrib><creatorcontrib>Kim, Jae Seung</creatorcontrib><creatorcontrib>Choe, Yearn Seong</creatorcontrib><creatorcontrib>Lee, Kyung Han</creatorcontrib><creatorcontrib>Kim, Sung Tae</creatorcontrib><creatorcontrib>Hwang, Jung Won</creatorcontrib><creatorcontrib>Jeong, Jee Hyang</creatorcontrib><creatorcontrib>Na, Duk L</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><jtitle>Neurobiology of aging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, Geon Ha</au><au>Lee, Jae Hong</au><au>Seo, Sang Won</au><au>Kim, Jeong Hun</au><au>Seong, Joon-Kyung</au><au>Ye, Byoung Seok</au><au>Cho, Hanna</au><au>Noh, Young</au><au>Kim, Hee Jin</au><au>Yoon, Cindy W</au><au>Oh, Seung Jun</au><au>Kim, Jae Seung</au><au>Choe, Yearn Seong</au><au>Lee, Kyung Han</au><au>Kim, Sung Tae</au><au>Hwang, Jung Won</au><au>Jeong, Jee Hyang</au><au>Na, Duk L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hippocampal volume and shape in pure subcortical vascular dementia</atitle><jtitle>Neurobiology of aging</jtitle><addtitle>Neurobiol Aging</addtitle><date>2015</date><risdate>2015</risdate><volume>36</volume><issue>1</issue><spage>485</spage><epage>491</epage><pages>485-491</pages><issn>0197-4580</issn><eissn>1558-1497</eissn><abstract>Abstract The purposes of the present study were to explore whether hippocampal atrophy exists in pure subcortical vascular dementia (SVaD) as defined by negative11 C-Pittsburg compound-B (PiB− ) positron emission tomography and to compare hippocampal volume and shape between PiB− SVaD and PiB positive (PiB+ ) Alzheimer's disease (AD) dementia. Hippocampal volume and shape were compared among 40 patients with PiB− SVaD, 34 with PiB+ AD, and 21 elderly with normal cognitive function (NC). The normalized hippocampal volume of PiB− SVaD was significantly smaller than NC but larger than that of PiB+ AD (NC > PiB− SVaD > PiB+ AD). Both PiB− SVaD and PiB+ AD patients had deflated shape changes in the cornus ammonis (CA) 1 and subiculum compared with NC. However, direct comparison between PiB− SVaD and PiB+ AD demonstrated more inward deformity in the subiculum of the left hippocampus in PiB+ AD. PiB− SVaD patients did have smaller hippocampal volumes and inward shape change on CA 1 and subiculum compared with NC, suggesting that cumulative ischemia without amyloid pathology could lead to hippocampal atrophy and shape changes.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>25444608</pmid><doi>10.1016/j.neurobiolaging.2014.08.009</doi><tpages>7</tpages></addata></record> |
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| subjects | Aged Aged, 80 and over Alzheimer Disease - diagnostic imaging Alzheimer Disease - pathology Alzheimer's disease Aniline Compounds Atrophy Carbon Radioisotopes Cognition Dementia, Vascular - diagnostic imaging Dementia, Vascular - pathology Dementia, Vascular - psychology Female Hippocampus Hippocampus - diagnostic imaging Hippocampus - pathology Humans Internal Medicine Magnetic Resonance Imaging Male Middle Aged Neurology PiB-PET Positron-Emission Tomography Radiopharmaceuticals Thiazoles Vascular dementia |
| title | Hippocampal volume and shape in pure subcortical vascular dementia |
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