ISAV infection promotes apoptosis of SHK-1 cells through a ROS/p38 MAPK/Bad signaling pathway

•ISAv modifies the redox state of SHK-1 cells through P38 MAPK.•ISAv induces a pro-apoptotic imbalance that leads to apoptosis.•Oxidative homeostasis regulates the survival of infected cells. The impact that the infectious salmon anemia virus (ISAV) has on the immune response of Salmo salar, from th...

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Veröffentlicht in:	Molecular immunology 2015-03, Vol.64 (1), p.1-8
Hauptverfasser:	Olavarría, Víctor H., Recabarren, Pablo, Fredericksen, Fernanda, Villalba, Melina, Yáñez, Alejandro
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Apoptosis Base Sequence bcl-Associated Death Protein - chemistry bcl-Associated Death Protein - genetics bcl-Associated Death Protein - metabolism Cell Line Fugu Head Kidney - enzymology Head Kidney - pathology Head Kidney - virology Infectious salmon anemia virus ISA virus Isavirus - physiology Models, Biological Molecular Sequence Data NADPH Orthomyxoviridae Infections - enzymology Orthomyxoviridae Infections - virology Oxidative stress p38 MAPK p38 Mitogen-Activated Protein Kinases - metabolism Promoter Regions, Genetic - genetics Reactive oxygen species (ROS) Reactive Oxygen Species - metabolism Salmo salar Signal Transduction
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