guanine nucleotide exchange factor Ric-8A induces domain separation and Ras domain plasticity in Gαi1

Heterotrimeric G proteins are activated by exchange of GDP for GTP at the G protein alpha subunit (Gα), most notably by G protein-coupled transmembrane receptors. Ric-8A is a soluble cytoplasmic protein essential for embryonic development that acts as both a guanine nucleotide exchange factor (GEF)...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2015-02, Vol.112 (5), p.1404-1409
Hauptverfasser:	Van Eps, Ned, Thomas, Celestine J., Hubbell, Wayne L., Sprang, Stephen R.
Format:	Artikel
Sprache:	eng
Schlagworte:	active sites Animals Biological Sciences Cattle cholinesterase inhibitors electron paramagnetic resonance spectroscopy Electron Spin Resonance Spectroscopy - methods embryogenesis G-protein coupled receptors GTP-Binding Protein alpha Subunits - chemistry GTP-Binding Protein alpha Subunits - metabolism Guanine Nucleotide Exchange Factors - chemistry Guanine Nucleotide Exchange Factors - genetics Guanine Nucleotide Exchange Factors - physiology guanosine triphosphate mechanism of action Models, Molecular ras Proteins - metabolism regulatory proteins
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