One-month toxicokinetic study of SHENMAI injection in rats

‘SHENMAI’ injection (SMI) has been widely used in cardioprotection and modulation of the immune system because of its great efficacy. SMI primarily comprises the saponins from Panax ginseng and Ophiopogon japonicas. The profiles of saponins in SMI during long-term toxicokinetics remain unclear. MiR-...

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Veröffentlicht in:	Journal of ethnopharmacology 2014-06, Vol.154 (2), p.391-399
Hauptverfasser:	Yu, Jian, Xin, Yan-Fei, Gu, Li-Qiang, Gao, Hai-Yan, Xia, Li-Juan, You, Zhen-Qiang, Xie, Feng, Ma, Zhu-Feng, Wang, Zhi, Xuan, Yao-Xian
Format:	Artikel
Sprache:	eng
Schlagworte:	Alanine Transaminase - blood Animals Aspartate Aminotransferases - blood Biomarkers - blood Creatine Kinase - blood Dose-Response Relationship, Drug Drug Combinations Drugs, Chinese Herbal - administration & dosage Drugs, Chinese Herbal - pharmacokinetics Drugs, Chinese Herbal - toxicity Ethnopharmacology Female Ginsenosides - administration & dosage Ginsenosides - blood Ginsenosides - toxicity Immunity, Innate - drug effects Immunity, Innate - immunology Male Medicine, Chinese Traditional MicroRNAs - blood Mir-146a Panax ginseng Rats, Sprague-Dawley Saponins - administration & dosage Saponins - blood Saponins - toxicity SHENMAI injection Spirostans - administration & dosage Spirostans - blood Spirostans - toxicity Time Factors Toxicokinetic Toxicokinetics
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