Biodegradation of the Antituberculosis Drug Isoniazid in the Aquatic Environment
As part of our study on pharmaceutical waste management in Ghana, we investigated the biodegradability of the most widely used antituberculosis drug isoniazid in the aquatic environment. The experiment was conducted using three tests from the Organization for Economic Co‐operation and Development gu...
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| Veröffentlicht in: | Clean : soil, air, water air, water, 2015-02, Vol.43 (2), p.166-172 |
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| creator | Sasu, Samuel Metzger, Jörg Kranert, Martin Kümmerer, Klaus |
| description | As part of our study on pharmaceutical waste management in Ghana, we investigated the biodegradability of the most widely used antituberculosis drug isoniazid in the aquatic environment. The experiment was conducted using three tests from the Organization for Economic Co‐operation and Development guidelines (close bottle test (CBT) 301D, low bacterial density i.e. |
| doi_str_mv | 10.1002/clen.201100147 |
| format | Article |
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The study was conducted to investigate the biodegradability of the mostly widely use antituberculosis drug isoniazid. The test samples analyzed after 28 days by HPLC‐UV showed a complete primary elimination of the test substance in MRT and ZWT.</description><identifier>ISSN: 1863-0650</identifier><identifier>EISSN: 1863-0669</identifier><identifier>DOI: 10.1002/clen.201100147</identifier><language>eng</language><publisher>Weinheim: Blackwell Publishing Ltd</publisher><subject>Biodegradation ; Biodegradation of the antituberculosis drug isoniazid in the aquatic environment ; Biological degradation ; Chromatography ; Fish ; Pharmaceuticals ; Sewage treatment plant ; Studies ; Surface water</subject><ispartof>Clean : soil, air, water, 2015-02, Vol.43 (2), p.166-172</ispartof><rights>2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4257-50b37183d8ae14636b3e19243061d6f3c32e7c9ee50cd69610cf134a292a0a793</citedby><cites>FETCH-LOGICAL-c4257-50b37183d8ae14636b3e19243061d6f3c32e7c9ee50cd69610cf134a292a0a793</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fclen.201100147$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fclen.201100147$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids></links><search><creatorcontrib>Sasu, Samuel</creatorcontrib><creatorcontrib>Metzger, Jörg</creatorcontrib><creatorcontrib>Kranert, Martin</creatorcontrib><creatorcontrib>Kümmerer, Klaus</creatorcontrib><title>Biodegradation of the Antituberculosis Drug Isoniazid in the Aquatic Environment</title><title>Clean : soil, air, water</title><addtitle>Clean Soil Air Water</addtitle><description>As part of our study on pharmaceutical waste management in Ghana, we investigated the biodegradability of the most widely used antituberculosis drug isoniazid in the aquatic environment. The experiment was conducted using three tests from the Organization for Economic Co‐operation and Development guidelines (close bottle test (CBT) 301D, low bacterial density i.e. <1000 colony forming units (CFU) mL−1, manometric respiratory test (MRT) 301 F, i.e. <1000 CFU mL−1 and the Zahn‐Wellens test (ZWT) 302B, i.e. <1000 CFU mL−1) employing different concentrations. At the end of the study, the results showed that isoniazid at concentrations of 4.29 mg L−1 for the CBT and 25.7 mg L−1 for the MRT were found not to be readily biodegradable in accordance with the test guidelines. In the ZWT, at a concentration of 142.92 mg L−1 which allows evaluation of aerobic degradation at high bacterial density, the results provided evidence for biological degradation of isoniazid. Finally, the test samples after 28 days analyzed by high performance liquid chromatography coupled to ultraviolet detector showed a complete primary elimination of the test substance in MRT and ZWT. The difference of the results obtained by HPLC and oxygen consumption in the MRT indicated the formation of stable transformation products, i.e. incomplete biodegradation, whilst there was no biodegradation at all in CBT.
The study was conducted to investigate the biodegradability of the mostly widely use antituberculosis drug isoniazid. The test samples analyzed after 28 days by HPLC‐UV showed a complete primary elimination of the test substance in MRT and ZWT.</description><subject>Biodegradation</subject><subject>Biodegradation of the antituberculosis drug isoniazid in the aquatic environment</subject><subject>Biological degradation</subject><subject>Chromatography</subject><subject>Fish</subject><subject>Pharmaceuticals</subject><subject>Sewage treatment plant</subject><subject>Studies</subject><subject>Surface water</subject><issn>1863-0650</issn><issn>1863-0669</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><recordid>eNqFkD1PwzAQhiMEEp8rcyQWlpSzndjxCKUURFUYQIyW61zAkNpgJ3z9eoKCKsTCdO9Jz3M6vUmyT2BEAOiRadCNKJB-IblYS7ZIyVkGnMv1VS5gM9mO8RGAA-FkK7k-sb7C-6Ar3VrvUl-n7QOmx661bbfAYLrGRxvT09DdpxfRO6s_bZVaN2AvXa-ZdOJebfBuia7dTTZq3UTc-5k7ye3Z5GZ8ns2uphfj41lmclqIrIAFE6RkVamR5JzxBUMiac6Ak4rXzDCKwkjEAkzFJSdgasJyTSXVoIVkO8nhcPc5-JcOY6uWNhpsGu3Qd1ERzoFJKUXZowd_0EffBdd_11MFUMKYoD01GigTfIwBa_Uc7FKHD0VAfResvgtWq4J7QQ7Cm23w4x9ajWeT-W83G1wbW3xfuTo8KS6YKNTdfKrKfH55KucnKmdfx_KM1Q</recordid><startdate>201502</startdate><enddate>201502</enddate><creator>Sasu, Samuel</creator><creator>Metzger, Jörg</creator><creator>Kranert, Martin</creator><creator>Kümmerer, Klaus</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QH</scope><scope>7ST</scope><scope>7UA</scope><scope>C1K</scope><scope>F1W</scope><scope>H97</scope><scope>L.G</scope><scope>SOI</scope><scope>7QO</scope><scope>7T7</scope><scope>7U6</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>201502</creationdate><title>Biodegradation of the Antituberculosis Drug Isoniazid in the Aquatic Environment</title><author>Sasu, Samuel ; Metzger, Jörg ; Kranert, Martin ; Kümmerer, Klaus</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4257-50b37183d8ae14636b3e19243061d6f3c32e7c9ee50cd69610cf134a292a0a793</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Biodegradation</topic><topic>Biodegradation of the antituberculosis drug isoniazid in the aquatic environment</topic><topic>Biological degradation</topic><topic>Chromatography</topic><topic>Fish</topic><topic>Pharmaceuticals</topic><topic>Sewage treatment plant</topic><topic>Studies</topic><topic>Surface water</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sasu, Samuel</creatorcontrib><creatorcontrib>Metzger, Jörg</creatorcontrib><creatorcontrib>Kranert, Martin</creatorcontrib><creatorcontrib>Kümmerer, Klaus</creatorcontrib><collection>Istex</collection><collection>CrossRef</collection><collection>Aqualine</collection><collection>Environment Abstracts</collection><collection>Water Resources Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 3: Aquatic Pollution & Environmental Quality</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>Environment Abstracts</collection><collection>Biotechnology Research Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Sustainability Science Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Clean : soil, air, water</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sasu, Samuel</au><au>Metzger, Jörg</au><au>Kranert, Martin</au><au>Kümmerer, Klaus</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Biodegradation of the Antituberculosis Drug Isoniazid in the Aquatic Environment</atitle><jtitle>Clean : soil, air, water</jtitle><addtitle>Clean Soil Air Water</addtitle><date>2015-02</date><risdate>2015</risdate><volume>43</volume><issue>2</issue><spage>166</spage><epage>172</epage><pages>166-172</pages><issn>1863-0650</issn><eissn>1863-0669</eissn><abstract>As part of our study on pharmaceutical waste management in Ghana, we investigated the biodegradability of the most widely used antituberculosis drug isoniazid in the aquatic environment. The experiment was conducted using three tests from the Organization for Economic Co‐operation and Development guidelines (close bottle test (CBT) 301D, low bacterial density i.e. <1000 colony forming units (CFU) mL−1, manometric respiratory test (MRT) 301 F, i.e. <1000 CFU mL−1 and the Zahn‐Wellens test (ZWT) 302B, i.e. <1000 CFU mL−1) employing different concentrations. At the end of the study, the results showed that isoniazid at concentrations of 4.29 mg L−1 for the CBT and 25.7 mg L−1 for the MRT were found not to be readily biodegradable in accordance with the test guidelines. In the ZWT, at a concentration of 142.92 mg L−1 which allows evaluation of aerobic degradation at high bacterial density, the results provided evidence for biological degradation of isoniazid. Finally, the test samples after 28 days analyzed by high performance liquid chromatography coupled to ultraviolet detector showed a complete primary elimination of the test substance in MRT and ZWT. The difference of the results obtained by HPLC and oxygen consumption in the MRT indicated the formation of stable transformation products, i.e. incomplete biodegradation, whilst there was no biodegradation at all in CBT.
The study was conducted to investigate the biodegradability of the mostly widely use antituberculosis drug isoniazid. The test samples analyzed after 28 days by HPLC‐UV showed a complete primary elimination of the test substance in MRT and ZWT.</abstract><cop>Weinheim</cop><pub>Blackwell Publishing Ltd</pub><doi>10.1002/clen.201100147</doi><tpages>7</tpages></addata></record> |
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| subjects | Biodegradation Biodegradation of the antituberculosis drug isoniazid in the aquatic environment Biological degradation Chromatography Fish Pharmaceuticals Sewage treatment plant Studies Surface water |
| title | Biodegradation of the Antituberculosis Drug Isoniazid in the Aquatic Environment |
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