Temporary elimination of IL-10 enhanced the effectiveness of cyclophosphamide and BMDC-based therapy by decrease of the suppressor activity of MDSCs and activation of antitumour immune response

Abstract The antitumour activity of the dendritic cell (DC)-based cellular vaccines is greatly reduced in hostile tumour microenvironment. Therefore, there are many attempts to eliminate or neutralize both suppressor cells and cytokines. The aim of the investigation was to verify if temporary elimin...

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Veröffentlicht in:	Immunobiology (1979) 2015-03, Vol.220 (3), p.389-398
Hauptverfasser:	Rossowska, Joanna, Anger, Natalia, Kicielińska, Jagoda, Pajtasz-Piasecka, Elżbieta, Bielawska-Pohl, Aleksandra, Wojas-Turek, Justyna, Duś, Danuta
Format:	Artikel
Sprache:	eng
Schlagworte:	Advanced Basic Science Allergy and Immunology Animals Anti-IL-10 antibodies Antibodies, Neutralizing - immunology Antigens, Neoplasm - immunology Antitumour chemoimmunotherapy Cancer Vaccines - immunology Colonic Neoplasms - therapy Cyclophosphamide Cyclophosphamide - therapeutic use Dendritic cells Dendritic Cells - immunology Dendritic Cells - transplantation Experimental MC38 colon carcinoma Female Immunotherapy - methods Interleukin-10 - genetics Interleukin-10 - immunology Interleukin-12 - genetics Killer Cells, Natural - immunology Lymphocyte Activation - immunology Lymphocytes, Tumor-Infiltrating - immunology Mice Mice, Inbred C57BL Myeloid derived suppressor cells Vaccines - immunology
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