Use of nonsteroidal anti-inflammatory drugs prior to chronic renal replacement therapy initiation: a nationwide study
ABSTRACT Purpose Nonsteroidal anti‐inflammatory drugs (NSAIDs) may be associated with severe renal complications, including acute renal failure, reduced glomerular filtration rate and interstitial nephritis. Caution against NSAIDs is therefore recommended in advanced chronic kidney disease. In this...
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| Veröffentlicht in: | Pharmacoepidemiology and drug safety 2012-04, Vol.21 (4), p.428-434 |
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| creator | Kristensen, Søren Lund Fosbøl, Emil L. Kamper, Anne-Lise Køber, Lars Hommel, Kristine Lamberts, Morten Abildstrøm, Steen Z. Blicher, Thalia M. Torp-Pedersen, Christian Gislason, Gunnar H. |
| description | ABSTRACT
Purpose
Nonsteroidal anti‐inflammatory drugs (NSAIDs) may be associated with severe renal complications, including acute renal failure, reduced glomerular filtration rate and interstitial nephritis. Caution against NSAIDs is therefore recommended in advanced chronic kidney disease. In this study, we examined NSAID use, aetiology and comorbidity among a national cohort of patients before the initiation of chronic renal replacement therapy (RRT).
Methods
Patients initiated on chronic RRT in the period 1997–2006 were identified in the Danish National Registry on Regular Dialysis and Transplantation, including etiological diagnosis. The use of NSAID before the start of RRT was studied by linkage to the National Prescription Register and comorbidity by linkage to the National Patient Registry.
Results
A total of 6663 patients were included in the study, and 2407 patients (36.1%) were prescribed NSAID in the 3 years before the start of RRT. These patients were older (mean age = 63.0 vs 61.4 years) and had a significantly higher degree of comorbidity (Charlson score = 2.85 vs 2.61, p |
| doi_str_mv | 10.1002/pds.3227 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1660395324</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1000406081</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4207-ec79d9a96f95ae9a114198c72fa3737d0614fbc17f6da8a06829463454452e0c3</originalsourceid><addsrcrecordid>eNqFkU1rFTEYhYNYbK2Cv0ACbtxMzXcm7vRqq1CqoMVlSJOMTZ1JxiRDnX9vrr22IBRX74H34VmcA8AzjI4wQuTV7MoRJUQ-AAcYKdVhzuXDbea067lQ--BxKVcItZ9ij8A-IZQx0aMDsJwXD9MAY4ql-pyCMyM0sYYuxGE002Rqyit0efle4JxDyrAmaC9zisHC7GPDs59HY_3kY4X10mczrzDEUIOpIcXX0MD4J10H52Gpi1ufgL3BjMU_3d1DcH78_uvmQ3f66eTj5s1pZxlBsvNWKqeMEoPixiuDMcOqt5IMhkoqHRKYDRcWy0E40xskeqKYoIwzxolHlh6ClzfeOaefiy9VT6FYP44m-rQUjYVAVHFK2P_R1h5DAvW4oS_-Qa_SklsTjeKM455TJe-ENqdSsh90q28yeW2qrY3otprertbQ5zvhcjF5dwv-nakB3Q1wHUa_3ivSn9992Ql3fGij_rrlTf6hRSuO629nJ5pvNsforRRa0d-f06-q</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1545185397</pqid></control><display><type>article</type><title>Use of nonsteroidal anti-inflammatory drugs prior to chronic renal replacement therapy initiation: a nationwide study</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Kristensen, Søren Lund ; Fosbøl, Emil L. ; Kamper, Anne-Lise ; Køber, Lars ; Hommel, Kristine ; Lamberts, Morten ; Abildstrøm, Steen Z. ; Blicher, Thalia M. ; Torp-Pedersen, Christian ; Gislason, Gunnar H.</creator><creatorcontrib>Kristensen, Søren Lund ; Fosbøl, Emil L. ; Kamper, Anne-Lise ; Køber, Lars ; Hommel, Kristine ; Lamberts, Morten ; Abildstrøm, Steen Z. ; Blicher, Thalia M. ; Torp-Pedersen, Christian ; Gislason, Gunnar H.</creatorcontrib><description>ABSTRACT
Purpose
Nonsteroidal anti‐inflammatory drugs (NSAIDs) may be associated with severe renal complications, including acute renal failure, reduced glomerular filtration rate and interstitial nephritis. Caution against NSAIDs is therefore recommended in advanced chronic kidney disease. In this study, we examined NSAID use, aetiology and comorbidity among a national cohort of patients before the initiation of chronic renal replacement therapy (RRT).
Methods
Patients initiated on chronic RRT in the period 1997–2006 were identified in the Danish National Registry on Regular Dialysis and Transplantation, including etiological diagnosis. The use of NSAID before the start of RRT was studied by linkage to the National Prescription Register and comorbidity by linkage to the National Patient Registry.
Results
A total of 6663 patients were included in the study, and 2407 patients (36.1%) were prescribed NSAID in the 3 years before the start of RRT. These patients were older (mean age = 63.0 vs 61.4 years) and had a significantly higher degree of comorbidity (Charlson score = 2.85 vs 2.61, p < 0.05) compared with patients not treated with NSAIDs. In the 3 years leading up to RRT, the number of patients treated with NSAID each year and the cumulated median length of treatment including all NSAIDs were stable at approximately 20% and 40 days, respectively.
Conclusions
In this study of a nationwide group of patients, we observed a widespread use of NSAID with an unaffected high annual incidence in the 3 years leading up to the initiation of RRT. Copyright © 2012 John Wiley & Sons, Ltd.</description><identifier>ISSN: 1053-8569</identifier><identifier>EISSN: 1099-1557</identifier><identifier>DOI: 10.1002/pds.3227</identifier><identifier>PMID: 22344680</identifier><language>eng</language><publisher>Chichester, UK: John Wiley & Sons, Ltd</publisher><subject>Age Factors ; Aged ; Anti-Inflammatory Agents, Non-Steroidal - administration & dosage ; Anti-Inflammatory Agents, Non-Steroidal - adverse effects ; Anti-Inflammatory Agents, Non-Steroidal - therapeutic use ; Comorbidity ; Denmark - epidemiology ; end-stage kidney disease ; Female ; Humans ; Kidney Diseases - epidemiology ; Kidney Diseases - etiology ; Kidney Diseases - therapy ; Kidney Failure, Chronic - epidemiology ; Kidney Failure, Chronic - etiology ; Kidney Failure, Chronic - therapy ; Male ; Medical Record Linkage ; Middle Aged ; nationwide ; NSAIDs ; pharmacoepidemiology ; Registries ; renal dialysis ; Renal Replacement Therapy - statistics & numerical data ; Time Factors</subject><ispartof>Pharmacoepidemiology and drug safety, 2012-04, Vol.21 (4), p.428-434</ispartof><rights>Copyright © 2012 John Wiley & Sons, Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4207-ec79d9a96f95ae9a114198c72fa3737d0614fbc17f6da8a06829463454452e0c3</citedby><cites>FETCH-LOGICAL-c4207-ec79d9a96f95ae9a114198c72fa3737d0614fbc17f6da8a06829463454452e0c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fpds.3227$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fpds.3227$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,777,781,1412,27905,27906,45555,45556</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22344680$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kristensen, Søren Lund</creatorcontrib><creatorcontrib>Fosbøl, Emil L.</creatorcontrib><creatorcontrib>Kamper, Anne-Lise</creatorcontrib><creatorcontrib>Køber, Lars</creatorcontrib><creatorcontrib>Hommel, Kristine</creatorcontrib><creatorcontrib>Lamberts, Morten</creatorcontrib><creatorcontrib>Abildstrøm, Steen Z.</creatorcontrib><creatorcontrib>Blicher, Thalia M.</creatorcontrib><creatorcontrib>Torp-Pedersen, Christian</creatorcontrib><creatorcontrib>Gislason, Gunnar H.</creatorcontrib><title>Use of nonsteroidal anti-inflammatory drugs prior to chronic renal replacement therapy initiation: a nationwide study</title><title>Pharmacoepidemiology and drug safety</title><addtitle>Pharmacoepidemiol Drug Saf</addtitle><description>ABSTRACT
Purpose
Nonsteroidal anti‐inflammatory drugs (NSAIDs) may be associated with severe renal complications, including acute renal failure, reduced glomerular filtration rate and interstitial nephritis. Caution against NSAIDs is therefore recommended in advanced chronic kidney disease. In this study, we examined NSAID use, aetiology and comorbidity among a national cohort of patients before the initiation of chronic renal replacement therapy (RRT).
Methods
Patients initiated on chronic RRT in the period 1997–2006 were identified in the Danish National Registry on Regular Dialysis and Transplantation, including etiological diagnosis. The use of NSAID before the start of RRT was studied by linkage to the National Prescription Register and comorbidity by linkage to the National Patient Registry.
Results
A total of 6663 patients were included in the study, and 2407 patients (36.1%) were prescribed NSAID in the 3 years before the start of RRT. These patients were older (mean age = 63.0 vs 61.4 years) and had a significantly higher degree of comorbidity (Charlson score = 2.85 vs 2.61, p < 0.05) compared with patients not treated with NSAIDs. In the 3 years leading up to RRT, the number of patients treated with NSAID each year and the cumulated median length of treatment including all NSAIDs were stable at approximately 20% and 40 days, respectively.
Conclusions
In this study of a nationwide group of patients, we observed a widespread use of NSAID with an unaffected high annual incidence in the 3 years leading up to the initiation of RRT. Copyright © 2012 John Wiley & Sons, Ltd.</description><subject>Age Factors</subject><subject>Aged</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - administration & dosage</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - adverse effects</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - therapeutic use</subject><subject>Comorbidity</subject><subject>Denmark - epidemiology</subject><subject>end-stage kidney disease</subject><subject>Female</subject><subject>Humans</subject><subject>Kidney Diseases - epidemiology</subject><subject>Kidney Diseases - etiology</subject><subject>Kidney Diseases - therapy</subject><subject>Kidney Failure, Chronic - epidemiology</subject><subject>Kidney Failure, Chronic - etiology</subject><subject>Kidney Failure, Chronic - therapy</subject><subject>Male</subject><subject>Medical Record Linkage</subject><subject>Middle Aged</subject><subject>nationwide</subject><subject>NSAIDs</subject><subject>pharmacoepidemiology</subject><subject>Registries</subject><subject>renal dialysis</subject><subject>Renal Replacement Therapy - statistics & numerical data</subject><subject>Time Factors</subject><issn>1053-8569</issn><issn>1099-1557</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1rFTEYhYNYbK2Cv0ACbtxMzXcm7vRqq1CqoMVlSJOMTZ1JxiRDnX9vrr22IBRX74H34VmcA8AzjI4wQuTV7MoRJUQ-AAcYKdVhzuXDbea067lQ--BxKVcItZ9ij8A-IZQx0aMDsJwXD9MAY4ql-pyCMyM0sYYuxGE002Rqyit0efle4JxDyrAmaC9zisHC7GPDs59HY_3kY4X10mczrzDEUIOpIcXX0MD4J10H52Gpi1ufgL3BjMU_3d1DcH78_uvmQ3f66eTj5s1pZxlBsvNWKqeMEoPixiuDMcOqt5IMhkoqHRKYDRcWy0E40xskeqKYoIwzxolHlh6ClzfeOaefiy9VT6FYP44m-rQUjYVAVHFK2P_R1h5DAvW4oS_-Qa_SklsTjeKM455TJe-ENqdSsh90q28yeW2qrY3otprertbQ5zvhcjF5dwv-nakB3Q1wHUa_3ivSn9992Ql3fGij_rrlTf6hRSuO629nJ5pvNsforRRa0d-f06-q</recordid><startdate>201204</startdate><enddate>201204</enddate><creator>Kristensen, Søren Lund</creator><creator>Fosbøl, Emil L.</creator><creator>Kamper, Anne-Lise</creator><creator>Køber, Lars</creator><creator>Hommel, Kristine</creator><creator>Lamberts, Morten</creator><creator>Abildstrøm, Steen Z.</creator><creator>Blicher, Thalia M.</creator><creator>Torp-Pedersen, Christian</creator><creator>Gislason, Gunnar H.</creator><general>John Wiley & Sons, Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>K9.</scope><scope>7X8</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>201204</creationdate><title>Use of nonsteroidal anti-inflammatory drugs prior to chronic renal replacement therapy initiation: a nationwide study</title><author>Kristensen, Søren Lund ; Fosbøl, Emil L. ; Kamper, Anne-Lise ; Køber, Lars ; Hommel, Kristine ; Lamberts, Morten ; Abildstrøm, Steen Z. ; Blicher, Thalia M. ; Torp-Pedersen, Christian ; Gislason, Gunnar H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4207-ec79d9a96f95ae9a114198c72fa3737d0614fbc17f6da8a06829463454452e0c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Age Factors</topic><topic>Aged</topic><topic>Anti-Inflammatory Agents, Non-Steroidal - administration & dosage</topic><topic>Anti-Inflammatory Agents, Non-Steroidal - adverse effects</topic><topic>Anti-Inflammatory Agents, Non-Steroidal - therapeutic use</topic><topic>Comorbidity</topic><topic>Denmark - epidemiology</topic><topic>end-stage kidney disease</topic><topic>Female</topic><topic>Humans</topic><topic>Kidney Diseases - epidemiology</topic><topic>Kidney Diseases - etiology</topic><topic>Kidney Diseases - therapy</topic><topic>Kidney Failure, Chronic - epidemiology</topic><topic>Kidney Failure, Chronic - etiology</topic><topic>Kidney Failure, Chronic - therapy</topic><topic>Male</topic><topic>Medical Record Linkage</topic><topic>Middle Aged</topic><topic>nationwide</topic><topic>NSAIDs</topic><topic>pharmacoepidemiology</topic><topic>Registries</topic><topic>renal dialysis</topic><topic>Renal Replacement Therapy - statistics & numerical data</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kristensen, Søren Lund</creatorcontrib><creatorcontrib>Fosbøl, Emil L.</creatorcontrib><creatorcontrib>Kamper, Anne-Lise</creatorcontrib><creatorcontrib>Køber, Lars</creatorcontrib><creatorcontrib>Hommel, Kristine</creatorcontrib><creatorcontrib>Lamberts, Morten</creatorcontrib><creatorcontrib>Abildstrøm, Steen Z.</creatorcontrib><creatorcontrib>Blicher, Thalia M.</creatorcontrib><creatorcontrib>Torp-Pedersen, Christian</creatorcontrib><creatorcontrib>Gislason, Gunnar H.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Pharmacoepidemiology and drug safety</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kristensen, Søren Lund</au><au>Fosbøl, Emil L.</au><au>Kamper, Anne-Lise</au><au>Køber, Lars</au><au>Hommel, Kristine</au><au>Lamberts, Morten</au><au>Abildstrøm, Steen Z.</au><au>Blicher, Thalia M.</au><au>Torp-Pedersen, Christian</au><au>Gislason, Gunnar H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Use of nonsteroidal anti-inflammatory drugs prior to chronic renal replacement therapy initiation: a nationwide study</atitle><jtitle>Pharmacoepidemiology and drug safety</jtitle><addtitle>Pharmacoepidemiol Drug Saf</addtitle><date>2012-04</date><risdate>2012</risdate><volume>21</volume><issue>4</issue><spage>428</spage><epage>434</epage><pages>428-434</pages><issn>1053-8569</issn><eissn>1099-1557</eissn><abstract>ABSTRACT
Purpose
Nonsteroidal anti‐inflammatory drugs (NSAIDs) may be associated with severe renal complications, including acute renal failure, reduced glomerular filtration rate and interstitial nephritis. Caution against NSAIDs is therefore recommended in advanced chronic kidney disease. In this study, we examined NSAID use, aetiology and comorbidity among a national cohort of patients before the initiation of chronic renal replacement therapy (RRT).
Methods
Patients initiated on chronic RRT in the period 1997–2006 were identified in the Danish National Registry on Regular Dialysis and Transplantation, including etiological diagnosis. The use of NSAID before the start of RRT was studied by linkage to the National Prescription Register and comorbidity by linkage to the National Patient Registry.
Results
A total of 6663 patients were included in the study, and 2407 patients (36.1%) were prescribed NSAID in the 3 years before the start of RRT. These patients were older (mean age = 63.0 vs 61.4 years) and had a significantly higher degree of comorbidity (Charlson score = 2.85 vs 2.61, p < 0.05) compared with patients not treated with NSAIDs. In the 3 years leading up to RRT, the number of patients treated with NSAID each year and the cumulated median length of treatment including all NSAIDs were stable at approximately 20% and 40 days, respectively.
Conclusions
In this study of a nationwide group of patients, we observed a widespread use of NSAID with an unaffected high annual incidence in the 3 years leading up to the initiation of RRT. Copyright © 2012 John Wiley & Sons, Ltd.</abstract><cop>Chichester, UK</cop><pub>John Wiley & Sons, Ltd</pub><pmid>22344680</pmid><doi>10.1002/pds.3227</doi><tpages>7</tpages></addata></record> |
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| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Age Factors Aged Anti-Inflammatory Agents, Non-Steroidal - administration & dosage Anti-Inflammatory Agents, Non-Steroidal - adverse effects Anti-Inflammatory Agents, Non-Steroidal - therapeutic use Comorbidity Denmark - epidemiology end-stage kidney disease Female Humans Kidney Diseases - epidemiology Kidney Diseases - etiology Kidney Diseases - therapy Kidney Failure, Chronic - epidemiology Kidney Failure, Chronic - etiology Kidney Failure, Chronic - therapy Male Medical Record Linkage Middle Aged nationwide NSAIDs pharmacoepidemiology Registries renal dialysis Renal Replacement Therapy - statistics & numerical data Time Factors |
| title | Use of nonsteroidal anti-inflammatory drugs prior to chronic renal replacement therapy initiation: a nationwide study |
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