Antiproliferative glabretal-type triterpenoids from the root bark of Dictamnus dasycarpus

[Display omitted] Four new glabretal-type triterpenoids, dictabretols A–D (1–4), were isolated by activity-guided fractionation from the root bark of Dictamnus dasycarpus T. (Rutaceae) using an in vitro antiproliferative assay on T cells using splenocytes. The structures of these compounds were dete...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2015-02, Vol.25 (3), p.621-625
Hauptverfasser:	Kim, Nahyun, Cho, Kyu-Won, Hong, Seong Su, Hwang, Bang Yeon, Chun, Taehoon, Lee, Dongho
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antiproliferative effect Cell Proliferation - drug effects Cell Survival Cells, Cultured Dictamnus - chemistry Dictamnus - metabolism Dictamnus dasycarpus Glabretal-type triterpenoid Immunosuppressive Agents - chemistry Immunosuppressive Agents - isolation & purification Immunosuppressive Agents - pharmacology Magnetic Resonance Spectroscopy Mice Molecular Conformation Plant Bark - chemistry Plant Bark - metabolism Plant Roots - chemistry Plant Roots - metabolism Rutaceae T-Lymphocytes - cytology T-Lymphocytes - drug effects Triterpenes - chemistry Triterpenes - isolation & purification Triterpenes - pharmacology
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