Antiproliferative glabretal-type triterpenoids from the root bark of Dictamnus dasycarpus
[Display omitted] Four new glabretal-type triterpenoids, dictabretols A–D (1–4), were isolated by activity-guided fractionation from the root bark of Dictamnus dasycarpus T. (Rutaceae) using an in vitro antiproliferative assay on T cells using splenocytes. The structures of these compounds were dete...
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| Veröffentlicht in: | Bioorganic & medicinal chemistry letters 2015-02, Vol.25 (3), p.621-625 |
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| container_title | Bioorganic & medicinal chemistry letters |
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| creator | Kim, Nahyun Cho, Kyu-Won Hong, Seong Su Hwang, Bang Yeon Chun, Taehoon Lee, Dongho |
| description | [Display omitted]
Four new glabretal-type triterpenoids, dictabretols A–D (1–4), were isolated by activity-guided fractionation from the root bark of Dictamnus dasycarpus T. (Rutaceae) using an in vitro antiproliferative assay on T cells using splenocytes. The structures of these compounds were determined by spectroscopic methods, including 2D NMR experiments. Compounds were evaluated for their immunosuppressive activity on T cells and demonstrated inhibition of proliferation of activated T cells, up to IC50 of 1.5μM. |
| doi_str_mv | 10.1016/j.bmcl.2014.12.007 |
| format | Article |
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Four new glabretal-type triterpenoids, dictabretols A–D (1–4), were isolated by activity-guided fractionation from the root bark of Dictamnus dasycarpus T. (Rutaceae) using an in vitro antiproliferative assay on T cells using splenocytes. The structures of these compounds were determined by spectroscopic methods, including 2D NMR experiments. Compounds were evaluated for their immunosuppressive activity on T cells and demonstrated inhibition of proliferation of activated T cells, up to IC50 of 1.5μM.</description><identifier>ISSN: 0960-894X</identifier><identifier>EISSN: 1464-3405</identifier><identifier>DOI: 10.1016/j.bmcl.2014.12.007</identifier><identifier>PMID: 25537268</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Animals ; Antiproliferative effect ; Cell Proliferation - drug effects ; Cell Survival ; Cells, Cultured ; Dictamnus - chemistry ; Dictamnus - metabolism ; Dictamnus dasycarpus ; Glabretal-type triterpenoid ; Immunosuppressive Agents - chemistry ; Immunosuppressive Agents - isolation & purification ; Immunosuppressive Agents - pharmacology ; Magnetic Resonance Spectroscopy ; Mice ; Molecular Conformation ; Plant Bark - chemistry ; Plant Bark - metabolism ; Plant Roots - chemistry ; Plant Roots - metabolism ; Rutaceae ; T-Lymphocytes - cytology ; T-Lymphocytes - drug effects ; Triterpenes - chemistry ; Triterpenes - isolation & purification ; Triterpenes - pharmacology</subject><ispartof>Bioorganic & medicinal chemistry letters, 2015-02, Vol.25 (3), p.621-625</ispartof><rights>2014 Elsevier Ltd</rights><rights>Copyright © 2014 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c503t-b6986e8055406a5b5be4f86eed71559eae0fa7b40423bfaf273b411f51f1bc5e3</citedby><cites>FETCH-LOGICAL-c503t-b6986e8055406a5b5be4f86eed71559eae0fa7b40423bfaf273b411f51f1bc5e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.bmcl.2014.12.007$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27922,27923,45993</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25537268$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kim, Nahyun</creatorcontrib><creatorcontrib>Cho, Kyu-Won</creatorcontrib><creatorcontrib>Hong, Seong Su</creatorcontrib><creatorcontrib>Hwang, Bang Yeon</creatorcontrib><creatorcontrib>Chun, Taehoon</creatorcontrib><creatorcontrib>Lee, Dongho</creatorcontrib><title>Antiproliferative glabretal-type triterpenoids from the root bark of Dictamnus dasycarpus</title><title>Bioorganic & medicinal chemistry letters</title><addtitle>Bioorg Med Chem Lett</addtitle><description>[Display omitted]
Four new glabretal-type triterpenoids, dictabretols A–D (1–4), were isolated by activity-guided fractionation from the root bark of Dictamnus dasycarpus T. (Rutaceae) using an in vitro antiproliferative assay on T cells using splenocytes. The structures of these compounds were determined by spectroscopic methods, including 2D NMR experiments. Compounds were evaluated for their immunosuppressive activity on T cells and demonstrated inhibition of proliferation of activated T cells, up to IC50 of 1.5μM.</description><subject>Animals</subject><subject>Antiproliferative effect</subject><subject>Cell Proliferation - drug effects</subject><subject>Cell Survival</subject><subject>Cells, Cultured</subject><subject>Dictamnus - chemistry</subject><subject>Dictamnus - metabolism</subject><subject>Dictamnus dasycarpus</subject><subject>Glabretal-type triterpenoid</subject><subject>Immunosuppressive Agents - chemistry</subject><subject>Immunosuppressive Agents - isolation & purification</subject><subject>Immunosuppressive Agents - pharmacology</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Mice</subject><subject>Molecular Conformation</subject><subject>Plant Bark - chemistry</subject><subject>Plant Bark - metabolism</subject><subject>Plant Roots - chemistry</subject><subject>Plant Roots - metabolism</subject><subject>Rutaceae</subject><subject>T-Lymphocytes - cytology</subject><subject>T-Lymphocytes - drug effects</subject><subject>Triterpenes - chemistry</subject><subject>Triterpenes - isolation & purification</subject><subject>Triterpenes - pharmacology</subject><issn>0960-894X</issn><issn>1464-3405</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkE1r3DAQhkVpaDZp_0AOQcde7EiyJNvQS0g_EgjkkkB6EpI8SrW1LVeSA_vvq2WTHktOA8Pzvsw8CJ1RUlNC5cW2NpMda0YorymrCWnfoQ3lklcNJ-I92pBekqrr-eMxOklpSwpIOP-AjpkQTctkt0E_L-fslxhG7yDq7J8BP43aRMh6rPJuAZyjzxAXmIMfEnYxTDj_AhxDyNjo-BsHh796m_U0rwkPOu2sjsuaPqIjp8cEn17mKXr4_u3-6rq6vftxc3V5W1lBmlwZ2XcSOiIEJ1ILIwxwVzYwtFSIHjQQp1tTDmeNcdqxtjGcUieoo8YKaE7R50Nv-eLPCimryScL46hnCGtSVErS9E3fiTeggnHK204WlB1QG0NKEZxaop903ClK1N6-2qq9fbW3ryhTxX4Jnb_0r2aC4V_kVXcBvhwAKEKePUSVrIfZwuAj2KyG4P_X_xdz4ZdA</recordid><startdate>20150201</startdate><enddate>20150201</enddate><creator>Kim, Nahyun</creator><creator>Cho, Kyu-Won</creator><creator>Hong, Seong Su</creator><creator>Hwang, Bang Yeon</creator><creator>Chun, Taehoon</creator><creator>Lee, Dongho</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>20150201</creationdate><title>Antiproliferative glabretal-type triterpenoids from the root bark of Dictamnus dasycarpus</title><author>Kim, Nahyun ; Cho, Kyu-Won ; Hong, Seong Su ; Hwang, Bang Yeon ; Chun, Taehoon ; Lee, Dongho</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c503t-b6986e8055406a5b5be4f86eed71559eae0fa7b40423bfaf273b411f51f1bc5e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Animals</topic><topic>Antiproliferative effect</topic><topic>Cell Proliferation - drug effects</topic><topic>Cell Survival</topic><topic>Cells, Cultured</topic><topic>Dictamnus - chemistry</topic><topic>Dictamnus - metabolism</topic><topic>Dictamnus dasycarpus</topic><topic>Glabretal-type triterpenoid</topic><topic>Immunosuppressive Agents - chemistry</topic><topic>Immunosuppressive Agents - isolation & purification</topic><topic>Immunosuppressive Agents - pharmacology</topic><topic>Magnetic Resonance Spectroscopy</topic><topic>Mice</topic><topic>Molecular Conformation</topic><topic>Plant Bark - chemistry</topic><topic>Plant Bark - metabolism</topic><topic>Plant Roots - chemistry</topic><topic>Plant Roots - metabolism</topic><topic>Rutaceae</topic><topic>T-Lymphocytes - cytology</topic><topic>T-Lymphocytes - drug effects</topic><topic>Triterpenes - chemistry</topic><topic>Triterpenes - isolation & purification</topic><topic>Triterpenes - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, Nahyun</creatorcontrib><creatorcontrib>Cho, Kyu-Won</creatorcontrib><creatorcontrib>Hong, Seong Su</creatorcontrib><creatorcontrib>Hwang, Bang Yeon</creatorcontrib><creatorcontrib>Chun, Taehoon</creatorcontrib><creatorcontrib>Lee, Dongho</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Bioorganic & medicinal chemistry letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, Nahyun</au><au>Cho, Kyu-Won</au><au>Hong, Seong Su</au><au>Hwang, Bang Yeon</au><au>Chun, Taehoon</au><au>Lee, Dongho</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antiproliferative glabretal-type triterpenoids from the root bark of Dictamnus dasycarpus</atitle><jtitle>Bioorganic & medicinal chemistry letters</jtitle><addtitle>Bioorg Med Chem Lett</addtitle><date>2015-02-01</date><risdate>2015</risdate><volume>25</volume><issue>3</issue><spage>621</spage><epage>625</epage><pages>621-625</pages><issn>0960-894X</issn><eissn>1464-3405</eissn><abstract>[Display omitted]
Four new glabretal-type triterpenoids, dictabretols A–D (1–4), were isolated by activity-guided fractionation from the root bark of Dictamnus dasycarpus T. (Rutaceae) using an in vitro antiproliferative assay on T cells using splenocytes. The structures of these compounds were determined by spectroscopic methods, including 2D NMR experiments. Compounds were evaluated for their immunosuppressive activity on T cells and demonstrated inhibition of proliferation of activated T cells, up to IC50 of 1.5μM.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>25537268</pmid><doi>10.1016/j.bmcl.2014.12.007</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Animals Antiproliferative effect Cell Proliferation - drug effects Cell Survival Cells, Cultured Dictamnus - chemistry Dictamnus - metabolism Dictamnus dasycarpus Glabretal-type triterpenoid Immunosuppressive Agents - chemistry Immunosuppressive Agents - isolation & purification Immunosuppressive Agents - pharmacology Magnetic Resonance Spectroscopy Mice Molecular Conformation Plant Bark - chemistry Plant Bark - metabolism Plant Roots - chemistry Plant Roots - metabolism Rutaceae T-Lymphocytes - cytology T-Lymphocytes - drug effects Triterpenes - chemistry Triterpenes - isolation & purification Triterpenes - pharmacology |
| title | Antiproliferative glabretal-type triterpenoids from the root bark of Dictamnus dasycarpus |
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