The histone demethylase Fbxl11/Kdm2a plays an essential role in embryonic development by repressing cell-cycle regulators

•Fbxl11 knock-out (KO) mice and reporter mice have been established.•Fbxl11 knock-out (KO) mice showed embryonic lethality and severely growth defects.•Fbxl11 KO lead to up-regulation of p21.•Fbxl11 promotes cell proliferation and viability during embryonic development.•The H2A ubiquitination, which...

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