Hepatocellular carcinoma and microRNA: New perspectives on therapeutics and diagnostics
Hepatocellular carcinoma (HCC) remains one of the most lethal forms of cancer in the world. In this arena, utilities of microRNA (miRNA) as a sophisticated tool, in therapeutics and diagnostics, remains a prime focus among the leading researchers. It is well known that viral hepatitis, chronic alcoh...
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| Veröffentlicht in: | Advanced drug delivery reviews 2015-01, Vol.81, p.62-74 |
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| creator | Yang, Ningning Ekanem, Nsikak R. Sakyi, Clement A. Ray, Sidhartha D. |
| description | Hepatocellular carcinoma (HCC) remains one of the most lethal forms of cancer in the world. In this arena, utilities of microRNA (miRNA) as a sophisticated tool, in therapeutics and diagnostics, remains a prime focus among the leading researchers. It is well known that viral hepatitis, chronic alcoholism and metabolic syndrome are the prime causes of HCCs. Nevertheless, HCCs are usually diagnosed at late stages by using current serum biomarkers. Most epidemiological studies have found the survival rate in HCC cases to be relatively low. Therefore, development of effective noninvasive biomarkers for early detention of HCC and new strategies for HCC treatment remains a high priority research area on the shoulders of liver oncologists. Accumulating evidence in cancer diagnostics and therapeutics indicates that miRNAs involve in HCC progression, which may serve as sensitive biomarkers for detecting carcinogenesis and monitoring therapies of HCC. This review focuses on the role of miRNAs in the diagnostics and therapeutics of HCC.
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| doi_str_mv | 10.1016/j.addr.2014.10.029 |
| format | Article |
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[Display omitted]</description><subject>Animals</subject><subject>Biomarker</subject><subject>Biomarkers, Tumor - blood</subject><subject>Carcinoma, Hepatocellular - diagnosis</subject><subject>Carcinoma, Hepatocellular - genetics</subject><subject>Carcinoma, Hepatocellular - therapy</subject><subject>Diagnostics</subject><subject>Disease Progression</subject><subject>Early Detection of Cancer</subject><subject>HCC</subject><subject>Humans</subject><subject>Liver Neoplasms - diagnosis</subject><subject>Liver Neoplasms - genetics</subject><subject>Liver Neoplasms - therapy</subject><subject>MicroRNAs - genetics</subject><subject>miRNA</subject><subject>Neoplasm Staging</subject><subject>Survival Rate</subject><subject>Therapeutics</subject><issn>0169-409X</issn><issn>1872-8294</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMtKxTAQhoMoery8gAvp0k2PSZqmqbgR8QaiIIruwjSZag6nF5NW8e1NPerS1TDDNz_8HyH7jM4ZZfJoMQdr_ZxTJuJhTnm5RmZMFTxVvBTrZBahMhW0fN4i2yEsKGW8kHSTbPFc5JRLOiNPV9jD0BlcLscl-MSAN67tGkigtUnjjO_ub0-Pk1v8SHr0oUczuHcMSdcmwyt66HEcnAnfuHXw0nZh2nfJRg3LgHs_c4c8Xpw_nF2lN3eX12enN6nJVDmkkAFgoRQ1aKwRipuqsDXlopJSFJVQeZ3XFVSScc7rvBClNFkOylqlOEib7ZDDVW7vu7cRw6AbF6Y20GI3Bs2kpFnJaCEiyldo7BSCx1r33jXgPzWjehKqF3oSqieh0y0KjU8HP_lj1aD9e_k1GIGTFYCx5btDr4Nx2Bq0zkdX2nbuv_wv6hqIJw</recordid><startdate>201501</startdate><enddate>201501</enddate><creator>Yang, Ningning</creator><creator>Ekanem, Nsikak R.</creator><creator>Sakyi, Clement A.</creator><creator>Ray, Sidhartha D.</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>201501</creationdate><title>Hepatocellular carcinoma and microRNA: New perspectives on therapeutics and diagnostics</title><author>Yang, Ningning ; Ekanem, Nsikak R. ; Sakyi, Clement A. ; Ray, Sidhartha D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c389t-a3aae7880cecdc482cb7df024b6647b485f5fbab61222f57496c35a8dd882a6d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Animals</topic><topic>Biomarker</topic><topic>Biomarkers, Tumor - blood</topic><topic>Carcinoma, Hepatocellular - diagnosis</topic><topic>Carcinoma, Hepatocellular - genetics</topic><topic>Carcinoma, Hepatocellular - therapy</topic><topic>Diagnostics</topic><topic>Disease Progression</topic><topic>Early Detection of Cancer</topic><topic>HCC</topic><topic>Humans</topic><topic>Liver Neoplasms - diagnosis</topic><topic>Liver Neoplasms - genetics</topic><topic>Liver Neoplasms - therapy</topic><topic>MicroRNAs - genetics</topic><topic>miRNA</topic><topic>Neoplasm Staging</topic><topic>Survival Rate</topic><topic>Therapeutics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yang, Ningning</creatorcontrib><creatorcontrib>Ekanem, Nsikak R.</creatorcontrib><creatorcontrib>Sakyi, Clement A.</creatorcontrib><creatorcontrib>Ray, Sidhartha D.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Advanced drug delivery reviews</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yang, Ningning</au><au>Ekanem, Nsikak R.</au><au>Sakyi, Clement A.</au><au>Ray, Sidhartha D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hepatocellular carcinoma and microRNA: New perspectives on therapeutics and diagnostics</atitle><jtitle>Advanced drug delivery reviews</jtitle><addtitle>Adv Drug Deliv Rev</addtitle><date>2015-01</date><risdate>2015</risdate><volume>81</volume><spage>62</spage><epage>74</epage><pages>62-74</pages><issn>0169-409X</issn><eissn>1872-8294</eissn><abstract>Hepatocellular carcinoma (HCC) remains one of the most lethal forms of cancer in the world. 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| subjects | Animals Biomarker Biomarkers, Tumor - blood Carcinoma, Hepatocellular - diagnosis Carcinoma, Hepatocellular - genetics Carcinoma, Hepatocellular - therapy Diagnostics Disease Progression Early Detection of Cancer HCC Humans Liver Neoplasms - diagnosis Liver Neoplasms - genetics Liver Neoplasms - therapy MicroRNAs - genetics miRNA Neoplasm Staging Survival Rate Therapeutics |
| title | Hepatocellular carcinoma and microRNA: New perspectives on therapeutics and diagnostics |
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