Changes in vitamin D target gene expression in adipose tissue monitor the vitamin D response of human individuals

SCOPE: Vitamin D₃, its biologically most active metabolite 1α,25‐dihydroxyvitamin D₃ (1,25(OH)₂D₃), and the vitamin D receptor (VDR) are important for adipose tissue biology. METHODS AND RESULTS: We extrapolated genomic VDR association loci in adipocytes from 55 conserved genome‐wide VDR‐binding sit...

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Veröffentlicht in:	Molecular nutrition & food research 2014-10, Vol.58 (10), p.2036-2045
Hauptverfasser:	Ryynänen, Jussi, Neme, Antonio, Tuomainen, Tomi‐Pekka, Virtanen, Jyrki K, Voutilainen, Sari, Nurmi, Tarja, Mello, Vanessa D. F, Uusitupa, Matti, Carlberg, Carsten
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - agonists Adaptor Proteins, Signal Transducing - chemistry Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - metabolism Adaptor Proteins, Vesicular Transport - agonists Adaptor Proteins, Vesicular Transport - chemistry Adaptor Proteins, Vesicular Transport - genetics Adaptor Proteins, Vesicular Transport - metabolism adipocytes Adipose tissue Adipose Tissue - metabolism Adipose Tissue - pathology Aged binding sites Biological and medical sciences biomarkers Biomarkers - metabolism biopsy Calcitriol - metabolism Cell Line Cells, Cultured cholecalciferol Cholecalciferol - administration & dosage Cholecalciferol - deficiency Cholecalciferol - metabolism Cholecalciferol - therapeutic use Chromatin immunoprecipitation Conserved Sequence Dietary Supplements Dual-Specificity Phosphatases - chemistry Dual-Specificity Phosphatases - genetics Dual-Specificity Phosphatases - metabolism Feeding. Feeding behavior Finland Fundamental and applied biological sciences. Psychology gene expression gene expression regulation genes Humans loci Male messenger RNA metabolites Mitogen-Activated Protein Kinase Phosphatases - chemistry Mitogen-Activated Protein Kinase Phosphatases - genetics Mitogen-Activated Protein Kinase Phosphatases - metabolism Nuclear Proteins - agonists Nuclear Proteins - chemistry Nuclear Proteins - genetics Nuclear Proteins - metabolism Receptors, Calcitriol - agonists Receptors, Calcitriol - genetics Receptors, Calcitriol - metabolism RNA, Messenger - metabolism Seasons Thrombomodulin - agonists Thrombomodulin - chemistry Thrombomodulin - genetics Thrombomodulin - metabolism Up-Regulation Vertebrates: anatomy and physiology, studies on body, several organs or systems Vitamin D Vitamin D Deficiency - diet therapy Vitamin D Deficiency - metabolism Vitamin D Deficiency - pathology Vitamin D receptor Vitamin D Response Element Vitamin D target genes
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