Design, synthesis, and DNA sequence selectivity of formaldehyde-mediated DNA-adducts of the novel N-(4-aminobutyl) acridine-4-carboxamide

A novel derivative of the anti-tumor agent N-[2-(dimethylamino)ethyl]acridine-4-carboxamide (DACA) was prepared by reduction of 9-oxoacridan-4-carboxylic acid to acridine-4-carboxylic acid with subsequent conversion to N-(4-aminobutyl)acridine-4-carboxamide (C4-DACA). Molecular modeling studies sugg...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2014-12, Vol.24 (24), p.5710-5715
Hauptverfasser:	Ankers, Elizabeth A, Evison, Benny J, Phillips, Don R, Brownlee, Robert T C, Cutts, Suzanne M
Format:	Artikel
Sprache:	eng
Schlagworte:	Acridines - chemistry Acridines - metabolism CpG Islands Disinfectants - pharmacology DNA Adducts - chemistry DNA Adducts - metabolism Drug Design Formaldehyde - pharmacology Isoquinolines - chemistry Isoquinolines - metabolism Models, Molecular Molecular Structure Topoisomerase II Inhibitors - chemistry Topoisomerase II Inhibitors - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!