Effect of a novel oral active iron chelator: 1-(N-acetyl-6-aminohexyl)-3-hydroxy-2-methylpyridin-4-one (CM1) in iron-overloaded and non-overloaded mice

To evaluate efficacy and toxicity of a novel orally active bidentate iron chelator, 1-(N-acetyl-6-aminohexyl)-3-hydroxy-2-methylpyridin-4-one (CM1) in mice under normal and iron overload conditions. Wild type C57BL/6 mice were fed with normal and 0.2% (w/w) ferrocene-supplemented (Fe) diets, respect...

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Veröffentlicht in:	Asian Pacific journal of tropical medicine 2014-09, Vol.7, p.S155-S161
Hauptverfasser:	Chansiw, Nittaya, Pangjit, Kanjana, Phisalaphong, Chada, Porter, John B., Evans, Patricia, Fucharoen, Suthat, Srichairatanakool, Somdet
Format:	Artikel
Sprache:	eng
Schlagworte:	Iron chelation Iron overload Liver enzyme Thalassemia Toxicity
Online-Zugang:	Volltext
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