Structure activity relationships of human galactokinase inhibitors

[Display omitted] Classic Galactosemia is a rare inborn error of metabolism that is caused by deficiency of galactose-1-phosphate uridyltransferase (GALT), an enzyme within the Leloir pathway that is responsible for the conversion of galactose-1-phosphate (gal-1-p) and UDP-glucose to glucose-1-phosp...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2015-02, Vol.25 (3), p.721-727
Hauptverfasser:	Liu, Li, Tang, Manshu, Walsh, Martin J., Brimacombe, Kyle R., Pragani, Rajan, Tanega, Cordelle, Rohde, Jason M., Baker, Heather L., Fernandez, Elizabeth, Blackman, Burchelle, Bougie, James M., Leister, William H., Auld, Douglas S., Shen, Min, Lai, Kent, Boxer, Matthew B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Benzoxazoles - chemical synthesis Benzoxazoles - chemistry Benzoxazoles - metabolism Crystallography, X-Ray Galactokinase Galactokinase - antagonists & inhibitors Galactokinase - genetics Galactokinase - metabolism Galactosemia Galactosephosphates - metabolism High-Throughput Screening Assays Humans Kinetics Mice Microsomes, Liver - metabolism Molecular Conformation Protein Binding Rats Recombinant Proteins - biosynthesis Recombinant Proteins - chemistry Recombinant Proteins - genetics Spiro Compounds - chemistry Structure-Activity Relationship Structure–activity relationships
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